Question · Q4 2025
Alexander Canani inquired about AMVUTTRA's access in community centers, specifically the proportion of the market inaccessible due to cost or stocking hesitancy, and the breakdown of new diagnoses and managed patients in community settings.
Answer
Tolga Tanguler, Chief Commercial Officer, stated that Alnylam is well-positioned from a payer access standpoint, with the large majority of patients having first-line access regardless of location. He highlighted broad and balanced experience, with alternative site of care agreements ensuring 90% of patients can access AMVUTTRA injections within 10 miles of their homes, having reached critical mass in 2025.
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