Alexander Kelly's questions to Theravance Biopharma Inc (TBPH) leadership • Q4 2024
Question
Alexander Kelly, on for Marc Frahm from TD Cowen, asked about the clinical bar for success for the Ampreloxetine CYPRESS study and the potential scale and timing of a commercial organization build-out assuming positive data.
Answer
Executive Rick Winningham stated that a statistically significant 1-point change in the OHSA composite score would be considered a clinical success. He and CFO Aziz Sawaf confirmed that any significant commercial build-out and increase in FTEs would occur only after positive CYPRESS data is received. CBO Rhonda Farnum added that the commercial effort could be highly efficient, targeting a concentrated group of about 3,000 prescribers.