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    Alexandria Hammond • Wolfe Research

    Alexandria Hammond's questions to Eli Lilly and Co (LLY) leadership

    Alexandria Hammond's questions to Eli Lilly and Co (LLY) leadership • Q2 2025

    Question

    Alexandria Hammond from Wolfe Research, LLC asked about the inclusion of total discontinuation rates for orforglipron, questioning if the 'unusually elevated' rates suggested an underlying issue that could have impacted efficacy.

    Answer

    Kenneth Custer, President of Lilly Cardiometabolic Health, responded that there was 'nothing remarkable' about the discontinuation rates, noting they were consistent with placebo rates in analogous obesity studies. He emphasized that the more critical metric, discontinuation due to adverse events, was low at 5-10%, which is in line with expectations for an oral GLP-1 agonist.

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    Alexandria Hammond's questions to Eli Lilly and Co (LLY) leadership • Q1 2025

    Question

    Alexandria Hammond asked for an update on the TRAILBLAZER-ALZ 3 study, specifically regarding the accrual of progression events and a reminder of what would constitute a successful trial outcome.

    Answer

    Anne White, President of Lilly Neuroscience, confirmed that the trial is event-based and the readout timing depends on event accrual, which could be earlier than the 2027 date on clinicaltrials.gov. She explained the goal is to significantly reduce the risk of people with elevated amyloid from ever experiencing symptoms of Alzheimer's. The primary endpoint is time to clinical progression, measured by the CDR global score, with success defined as preventing the move to the symptomatic stage.

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    Alexandria Hammond's questions to Eli Lilly and Co (LLY) leadership • Q4 2024

    Question

    Alexandria Hammond of Wolfe Research asked how the partnership with Ro is envisioned to evolve and requested framing the opportunity for step-down vials.

    Answer

    Executive Patrik Jonsson explained the Ro partnership is a non-financial platform to help patients access authentic medicine via LillyDirect, with similar partnerships to follow. He noted step-down vials are in the low teens for new therapy starts, indicating strong initial uptake.

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    Alexandria Hammond's questions to Amgen Inc (AMGN) leadership

    Alexandria Hammond's questions to Amgen Inc (AMGN) leadership • Q2 2025

    Question

    Alexandria Hammond inquired about the evolving regulatory landscape for biosimilars, including the feasibility of using PK comparability instead of Phase 3 trials, and the potential impact on Amgen's long-term sales guidance.

    Answer

    James Bradner, EVP of R&D, noted that a potential softening of requirements would play to Amgen's strengths. Murdo Gordon, EVP of Global Commercial Operations, emphasized it remains a technically difficult field. Robert Bradway, Chairman & CEO, concluded the market is developing as expected.

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    Alexandria Hammond's questions to Amgen Inc (AMGN) leadership • Q1 2025

    Question

    Alexandria Hammond of Wolfe Research asked about the future market dynamics for rocatinlumab in atopic dermatitis, questioning if management anticipates an even split with key competitors.

    Answer

    Murdo Gordon, EVP of Global Commercial Operations, stated that Amgen sees a significant opportunity for rocatinlumab, given the large refractory patient population in atopic dermatitis. However, he declined to speculate on a specific future market share split against other agents that are also still in development, but reiterated confidence in the drug's potential.

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    Alexandria Hammond's questions to Amgen Inc (AMGN) leadership • Q4 2024

    Question

    Alexandria Hammond asked about Amgen's strategy for sourcing innovation from China and its general appetite for M&A following the large Horizon acquisition.

    Answer

    CEO Robert Bradway reiterated a consistent business development strategy, stating the company is actively searching for value-adding molecules globally, including in China. He confirmed that Amgen remains 'open for business' for both licensing and acquisition opportunities.

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    Alexandria Hammond's questions to Pfizer Inc (PFE) leadership

    Alexandria Hammond's questions to Pfizer Inc (PFE) leadership • Q2 2025

    Question

    Alexandria Hammond of Wolfe Research, LLC questioned how the recently announced direct-to-consumer purchasing option for Eliquis could be applied to the rest of Pfizer's portfolio.

    Answer

    Chairman & CEO Albert Bourla responded that the direct-to-consumer model is a "fantastic way to go" and aligns with administration requests. He highlighted Pfizer's experience with its 'Pfizer for All' platform and the new 'Eliquis 360' program with Bristol Myers Squibb, noting broad industry support for such initiatives to improve patient access and affordability.

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    Alexandria Hammond's questions to Pfizer Inc (PFE) leadership • Q2 2025

    Question

    Alexandria Hammond of Wolfe Research, LLC questioned how the recently announced direct-to-consumer purchasing option for Eliquis could be applied to the rest of Pfizer's product portfolio.

    Answer

    CEO Albert Bourla responded that the direct-to-consumer model is a 'fantastic way to go' and aligns with requests from the administration. He noted Pfizer has experience with its 'Pfizer for all' website and the new 'Eliquis 360' program, and that the broader industry is ready to execute similar initiatives.

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    Alexandria Hammond's questions to Pfizer Inc (PFE) leadership • Q4 2024

    Question

    Alexandria Hammond asked about the near-term commercial dynamics for VYNDAQEL, given new market competition, and where the largest impact on market share might occur.

    Answer

    Executive Aamir Malik acknowledged that while new competition and the IRA will be headwinds, VYNDAQEL's growth will be supported by increased diagnosis rates and favorable affordability. He expressed confidence that its robust clinical profile, real-world data, and strong access will maintain its position as the standard of care.

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    Alexandria Hammond's questions to Regeneron Pharmaceuticals Inc (REGN) leadership

    Alexandria Hammond's questions to Regeneron Pharmaceuticals Inc (REGN) leadership • Q2 2025

    Question

    Alexandria Hammond of Wolfe Research asked about the upcoming data for the C5 program (pozelimab) in generalized myasthenia gravis (gMG), specifically inquiring about the bar for clinical and commercial success.

    Answer

    President & CSO Dr. George Yancopoulos stated the clinical goal is to show efficacy similar to existing agents but with a much more convenient monthly subcutaneous dosing regimen. EVP of Commercial Marion McCourt added that in this large market with unmet need, a differentiated product offering convenience with a good safety profile would be commercially important.

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    Alexandria Hammond's questions to Regeneron Pharmaceuticals Inc (REGN) leadership • Q2 2025

    Question

    Alexandria Hammond of Wolfe Research asked about the upcoming pozetelimab readout in generalized myasthenia gravis (gMG), inquiring about the bar for both clinical and commercial success.

    Answer

    President & CSO Dr. George Yancopoulos stated the clinical goal is to show efficacy similar to existing agents but with a more convenient monthly subcutaneous dosing regimen. EVP of Commercial Marion McCourt added that this convenience, in a large market with unmet need, would be a key commercial driver, alongside a strong safety profile.

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    Alexandria Hammond's questions to Regeneron Pharmaceuticals Inc (REGN) leadership • Q1 2025

    Question

    Alexandria Hammond of Wolfe Research asked about the Factor XI antibody program, specifically how Regeneron is prioritizing indications, the anticipated launch timing, and any updates on regulatory discussions regarding trial design.

    Answer

    An executive, likely CSO Dr. George Yancopoulos, stated that the company is pursuing a mix of longer-term indications and undisclosed ones with a potentially faster path to market. The priority is on studies demonstrating both anticoagulation benefits and a superior, lower bleeding risk profile. It was confirmed that pivotal Phase III studies are set to begin enrollment in 2025.

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    Alexandria Hammond's questions to BioMarin Pharmaceutical Inc (BMRN) leadership

    Alexandria Hammond's questions to BioMarin Pharmaceutical Inc (BMRN) leadership • Q2 2025

    Question

    Alexandria Hammond of Wolfe Research asked for an update on VOXZOGO commercial efforts, specifically the average time from prescription to treatment and the progress of increasing referrals from pediatricians.

    Answer

    Cristin Hubbard, EVP and Chief Commercial Officer, stated that the focus is on reducing the time from diagnosis to treatment, which can take months. She highlighted strong uptake in the youngest patient cohorts (0-2 and 2-4 years old) and confirmed that the strategy of driving referrals from pediatricians to specialists is successful, with growth seen across all treater types, including pediatricians, geneticists, and endocrinologists.

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    Alexandria Hammond's questions to Merck & Co Inc (MRK) leadership

    Alexandria Hammond's questions to Merck & Co Inc (MRK) leadership • Q2 2025

    Question

    Alexandria Hammond from Wolfe Research LLC asked about enlicitide's potential as a platform for other cardiometabolic assets, inquiring about expected combinations, indications, and the timing of future updates.

    Answer

    Dr. Dean Li, President of Merck Research Labs, explained the ambition for enlicitide to be a best-in-class oral PCSK9 inhibitor. He outlined its potential as a platform for combinations to deepen LDL response, as well as combinations with agents targeting Lp(a) and inflammatory pathways to further improve cardiovascular outcomes.

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    Alexandria Hammond's questions to Merck & Co Inc (MRK) leadership • Q2 2025

    Question

    Alexandria Hammond of Wolfe Research LLC asked about the strategy for enlicitide as a platform asset, inquiring about potential future combinations, additional indications, and the timing of any updates.

    Answer

    Dr. Dean Li, President of Merck Research Laboratories, described the ambition for enlicitide to be the best-in-class oral PCSK9 inhibitor. He outlined a combination strategy focused on deepening LDL reduction, as well as targeting other cardiovascular risk factors like Lp(a) and inflammation. He positioned enlicitide as a foundational molecule for driving significant improvements in cardiovascular outcomes.

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    Alexandria Hammond's questions to Merck & Co Inc (MRK) leadership • Q1 2025

    Question

    Alexandria Hammond of Wolfe Research inquired about the importance of a potential ACIP wording update for the HPV vaccine recommendation to include ages 9-12 for U.S. sales.

    Answer

    CEO Robert Davis described the potential change as a 'very important and positive development.' He explained that starting vaccination at age 9 could improve completion rates and allow for better focus on the vaccine. While not a 'big upside' since it's already approved, he said the ACIP recommendation would reinforce its importance.

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    Alexandria Hammond's questions to Johnson & Johnson (JNJ) leadership

    Alexandria Hammond's questions to Johnson & Johnson (JNJ) leadership • Q2 2025

    Question

    Alexandria Hammond of Wolfe Research, LLC inquired about the launch strategy for TAR-200, including commercial readiness and patient penetration expectations for the bladder cancer therapy.

    Answer

    EVP Jennifer Taubert described TAR-200 as a product that represents the best of J&J, leveraging both Innovative Medicine and MedTech capabilities for development and training. She highlighted the large patient opportunity and confirmed that launch planning is well underway to support what the company expects to be a very successful launch, starting in BCG-failed patients before expanding.

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    Alexandria Hammond's questions to Johnson & Johnson (JNJ) leadership • Q4 2024

    Question

    Alexandria Hammond asked about the expected sales growth cadence for CAPLYTA following the Intracellular Therapies acquisition and whether this deal would lead to the deprioritization of other neuroscience assets like seltorexant.

    Answer

    Executive Jennifer Taubert stated that CAPLYTA's growth will be catalyzed by the potential approval for major depressive disorder (MDD), which is its largest potential indication. An executive, likely John Reed, affirmed that other neuroscience assets will not be deprioritized, as the company's strategy is to build a broad portfolio with unique mechanisms to treat the heterogeneous nature of depression, highlighting the benign side-effect profiles across the portfolio.

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    Alexandria Hammond's questions to AbbVie Inc (ABBV) leadership

    Alexandria Hammond's questions to AbbVie Inc (ABBV) leadership • Q1 2025

    Question

    Alexandria Hammond of Wolfe Research asked about the expected timing for results from the Skyrizi and Rinvoq combination trials and which combination AbbVie is most excited about from a mechanistic standpoint.

    Answer

    CSO Roopal Thakkar stated that early data from the combination studies should begin reading out next year. He expressed excitement about several mechanisms, including combinations with an alpha 4 beta 7, the bispecific lutikizumab (anti-IL-1 alpha/beta), and a longer-acting TL1A antibody. CEO Robert Michael added that these combinations are part of a long-term strategy to elevate the standard of care and drive the company's 'third chapter' of growth beyond the current Skyrizi and Rinvoq indications.

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    Alexandria Hammond's questions to Gilead Sciences Inc (GILD) leadership

    Alexandria Hammond's questions to Gilead Sciences Inc (GILD) leadership • Q1 2025

    Question

    Alexandria Hammond asked about the expected impact of the 340B channel mix on HIV pricing in 2025 and how utilization in that channel might compare to 2024.

    Answer

    Chief Commercial Officer Johanna Mercier noted that while the 340B channel has grown, they hope it will stabilize. She affirmed Gilead's support for the program's original intent but called for more transparency to reduce duplicate discounts. No new trends beyond the ongoing growth seen in 2024 were projected for 2025.

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