Ananda Ghosh's questions to Amylyx Pharmaceuticals Inc (AMLX) leadership • Q3 2024
Question
Ananda Ghosh of H.C. Wainwright & Co. asked for details on the pharmacokinetic (PK) profile of the 90mg dose of avexitide, specifically regarding how quickly it counters hypoglycemic events post-dosing.
Answer
Dr. Camille Bedrosian, Chief Medical Officer, explained that avexitide reaches therapeutic range approximately one hour post-dosing and provides coverage for about 24 hours. She noted that PK/PD modeling and early single-dose studies showed a quick onset of effect, which is consistent with its mechanism of competing with endogenous GLP-1 at the receptor level.