Question · Q3 2025
Andrew Behrens inquired about the decision to terminate the Povorcitinib program in Chronic Spontaneous Urticaria (CSU) despite successful Phase 2 results, asking if the data would still be released. He also asked if combination data for the TGF-beta by PD-1 bispecific (890) would be available before its advancement into Phase 3.
Answer
CEO Bill Meury explained that the Povorcitinib CSU termination was due to prioritization, focusing on programs with better returns, differentiation, competitive intensity, and market potential. President Pablo Cagnoni added that the regulatory bar for CSU was onerous and confirmed that data release is likely at a future conference. For 890, Pablo Cagnoni stated the decision to advance to Phase 3 in first-line colorectal cancer is made, and combination data will be released next year, in parallel with the trial initiation.