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    Ashwani Verma • UBS Group AG

    Ashwani Verma's questions to Alvotech SA (ALVO) leadership

    Ashwani Verma's questions to Alvotech SA (ALVO) leadership • Q2 2025

    Question

    Ashwani Verma of UBS Group AG sought confirmation on whether the full-year 2025 revenue and EBITDA guidance ranges remain intact given the first-half performance. He also asked for projections on the U.S. market share dynamics for both Humira and Stelara biosimilars through the end of the year.

    Answer

    CEO Róbert Wessman confirmed that H1 results were in line with expectations and the company is not changing its guidance, reiterating that Q4 is expected to be the strongest quarter. CCO Anil Okay detailed market share performance, noting continued growth in Europe for Humira biosimilars, a top-three position in the U.S., and strong performance for the Stelara biosimilar in Europe with U.S. uptake proceeding as forecast.

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    Ashwani Verma's questions to Alvotech SA (ALVO) leadership • Q1 2024

    Question

    Ashwani Verma from UBS sought a clarification on the 1 million units of the HUMIRA biosimilar mentioned in the prepared remarks, asking if the unit of measure was pens.

    Answer

    Chief Commercial Officer Anil Okay confirmed that the binding purchase orders for over 1 million units are indeed measured in pens.

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    Ashwani Verma's questions to Legend Biotech Corp (LEGN) leadership

    Ashwani Verma's questions to Legend Biotech Corp (LEGN) leadership • Q2 2025

    Question

    Ashwani Verma asked about the ramp of Novartis's commercial supply in the second half, the potential for CARTITUDE-V data in calendar year 2026, and the possibility of seeing data from CARTITUDE-II cohorts E and F later this year.

    Answer

    Alan Bash, President of CARVYKTI, clarified that the Novartis supply has been ramping since its approval and is expected to reach full capacity by year-end, contributing to growth throughout the second half. Interim CFO Jessie Yeung reiterated that CARTITUDE-V is event-driven and declined to comment on data timelines or future conference submissions for CARTITUDE-II.

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    Ashwani Verma's questions to Legend Biotech Corp (LEGN) leadership • Q1 2025

    Question

    Ashwani Verma of UBS questioned if the Q2 sales step-up from new Novartis supply would be as significant as the growth seen in Q3 of the prior year and asked for thoughts on potential neurotoxicity data from a competitor.

    Answer

    Alan Bash, President of CARVYKTI, projected a modest step-up in Q2 with further acceleration in the second half of the year, noting strong Q1 performance was partly due to faster-than-expected ramping at the Obelisc facility. Chief Medical Officer Mythili Koneru declined to comment on competitor data but highlighted excitement for Legend's own long-term CARTITUDE-1 data at ASCO and the successful implementation of safety monitoring protocols.

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    Ashwani Verma's questions to Legend Biotech Corp (LEGN) leadership • Q4 2024

    Question

    Ashwani Verma asked when the Novartis commercial manufacturing facility will begin to provide a meaningful benefit and what percentage of capacity it will represent. He also questioned how the ALC monitoring protocol from the Tandem data would be adopted in the community setting and if it could be a hurdle.

    Answer

    Executive Alan Bash said that with the recent approval, the Novartis facility is expected to start contributing meaningfully in the second quarter of the year, though a specific capacity percentage was not provided. Executive Jessie Yeung addressed the second question, explaining that ALC is a common lab test and low-dose steroids are inexpensive and readily available, making the mitigation strategy easily adoptable in both academic and community settings without significant resistance.

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    Ashwani Verma's questions to Cytokinetics Inc (CYTK) leadership

    Ashwani Verma's questions to Cytokinetics Inc (CYTK) leadership • Q2 2025

    Question

    Ashwani Verma of UBS Group asked whether the pushout of the late-cycle meeting to September was a direct result of the PDUFA extension or a separate development that could cause further delays.

    Answer

    President and CEO Robert Blum confirmed the later meeting date is consistent with the three-month PDUFA extension and is not a separate development. He stated they have no reason to believe there are other issues and that interactions with the FDA indicate the review is proceeding toward the new PDUFA date.

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    Ashwani Verma's questions to Viatris Inc (VTRS) leadership

    Ashwani Verma's questions to Viatris Inc (VTRS) leadership • Q2 2025

    Question

    Ashwani Verma from UBS asked about the drivers of the strong China performance and the focus of BD efforts there, as well as the scope, timeline, and potential for cost optimization from the enterprise-wide strategic review.

    Answer

    CCO Corinne Le Goff attributed the 9% China growth to a diversified commercial model and customer buying patterns, expecting it to moderate to low-to-mid single digits. CEO Scott Smith confirmed China is an active area for BD. Regarding the strategic review, Smith stated it covers all aspects of the business to improve efficiency, expects significant cost savings, and aims to provide detailed granularity on the Q3 earnings call.

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    Ashwani Verma's questions to Viatris Inc (VTRS) leadership • Q1 2025

    Question

    Ashwani Verma from UBS asked about the company's appetite for more aggressive share repurchases given the stock price and sought specifics on meloxicam's onset of action and the potential for a 'fast-acting' label claim.

    Answer

    CEO Scott Smith and CFO Theodora Mistras confirmed their commitment to the existing $500-$650 million share repurchase plan but noted they retain strategic flexibility to potentially increase it, given market volatility. Chief R&D Officer Philippe Martin provided data showing a rapid onset of pain relief for meloxicam but stated he could not speculate on a specific FDA label claim.

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    Ashwani Verma's questions to Viatris Inc (VTRS) leadership • Q4 2024

    Question

    Ashwani Verma of UBS inquired about the implications of the Indore warning letter for 2026, particularly regarding offsets for the accelerated loss of lenalidomide revenue, and questioned why the company was not planning a more aggressive share buyback given the stock's pre-market decline.

    Answer

    CEO Scott Smith explained that the lenalidomide financial impact was an event expected for early 2026 that has been pulled forward by 10-12 months. He characterized the guided $500M-$650M share repurchase for 2025 as a minimum, stating the company has flexibility to be more aggressive and will evaluate doing so if the stock remains under pressure, balancing it with accretive business development.

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    Ashwani Verma's questions to Viatris Inc (VTRS) leadership • Q3 2024

    Question

    Ashwani Verma of UBS asked how Viatris plans to balance business development investments with share repurchases, given that debt paydown targets are nearly met and the stock is trading at a low valuation. He also inquired when the supply chain impacts on the ARV business in emerging markets would be resolved.

    Answer

    CEO Scott Smith confirmed that reaching their leverage target allows for a balanced capital allocation strategy, but noted that given the current stock valuation, Viatris may be 'more aggressive on the share buyback side' in 2025. CFO Theodora Mistras clarified that the recent ARV issue was due to specific supply delays, not therapy shifts, and the company is working to resolve the backlogs.

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    Ashwani Verma's questions to ACADIA Pharmaceuticals Inc (ACAD) leadership

    Ashwani Verma's questions to ACADIA Pharmaceuticals Inc (ACAD) leadership • Q2 2025

    Question

    Ashwani Verma asked about the timeline for NUPLAZID's eligibility for IRA price negotiation. He also questioned if the ACP101 formulation, which requires refrigeration and thrice-daily dosing, could be a hindrance and if a room-temperature stable version is planned.

    Answer

    CFO Mark Schneyer projected that 2029 would be the first year NUPLAZID is eligible for IRA negotiation, with a potential one-year delay if the 'pill penalty' is removed. EVP, Head of R&D, Elizabeth Thompson, explained that the current ACP101 formulation is being used to maintain consistency for the FDA resubmission and has been acceptable in trials. She added that the company is always considering next-generation, patient-friendly product improvements.

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    Ashwani Verma's questions to ACADIA Pharmaceuticals Inc (ACAD) leadership • Q1 2025

    Question

    Ashwani Verma of UBS questioned the company's confidence in the low-dose carbetocin (ACP-101) data, given a prior trial showed an inverse dose relationship, and also asked for the company's perspective on the use of GLP-1s in Prader-Willi syndrome.

    Answer

    An executive, likely Head of R&D Elizabeth Thompson, detailed that confidence in the 3.2mg dose stems from its mechanistic rationale, internal consistency in prior data, and a plausible hypothesis that off-target effects at the higher dose obscured the benefit. Regarding GLP-1s, she stated that their utility in the Prader-Willi patient population remains unproven.

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    Ashwani Verma's questions to Royalty Pharma PLC (RPRX) leadership

    Ashwani Verma's questions to Royalty Pharma PLC (RPRX) leadership • Q2 2025

    Question

    Ashwani Verma of UBS Group AG asked for Royalty Pharma's perspective on the competitive landscape for biopharma royalties, particularly how the scaling up of competitors like Healthcare Royalty Partners (acquired by KKR) impacts its ability to win large transactions.

    Answer

    CEO Pablo Legorreta stated that the company welcomes competition and emphasized Royalty Pharma's significant advantages, including its unique integrated structure, very low cost of capital, massive scale for multi-billion dollar deals, an experienced team, and deep industry relationships, which allow it to win desirable assets.

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    Ashwani Verma's questions to Royalty Pharma PLC (RPRX) leadership • Q4 2024

    Question

    Ashwani Verma sought clarification on the 2025 guidance for operating and professional costs, asking if the 10% figure reflects the internalization and how the previously mentioned $100 million in savings is calculated. He also asked if the Alyftrek royalty dispute needs to be resolved before the first royalty payment becomes due.

    Answer

    EVP and CFO Terrance Coyne confirmed the 10% operating cost guidance does not yet reflect the internalization and that the post-internalization run-rate is expected to be around 4-5%, which accounts for the savings. Regarding the Alyftrek royalty timing, he reiterated that he could not provide any specific details on a resolution timeline.

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    Ashwani Verma's questions to Royalty Pharma PLC (RPRX) leadership • Q3 2024

    Question

    Ashwani Verma questioned whether Nictimbo's intravenous (IV) administration could become a bottleneck for adoption, considering that many chronic GVHD patients are treated in an outpatient setting.

    Answer

    Marshall Urist, EVP, Head of Research and Investments, acknowledged that the IV administration was factored into their forecasts. However, he stressed that for patients who have already failed existing oral therapies and carry a significant symptom burden, the high unmet need makes Nictimbo a critical and compelling option, which should drive adoption despite the administration route.

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    Ashwani Verma's questions to Harmony Biosciences Holdings Inc (HRMY) leadership

    Ashwani Verma's questions to Harmony Biosciences Holdings Inc (HRMY) leadership • Q2 2025

    Question

    Ashwani Verma of UBS Group questioned the implications of focusing the Fragile X trial on the 'full methylation' patient subgroup, asking about the size of this population and for regulatory precedents where the FDA accepted data from a similar genetically-defined subgroup.

    Answer

    Chief Medical & Scientific Officer Dr. Kumar Budur explained that fully methylated patients comprise 60-70% of the Fragile X population and have a higher symptom burden, aligning with ZYN-two's mechanism. He confirmed extensive discussions and full alignment with both the FDA and EMA on this targeted approach. President & CEO Dr. Jeffrey Dayno reiterated that the strategy follows both the science and the data from the prior study.

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    Ashwani Verma's questions to Harmony Biosciences Holdings Inc (HRMY) leadership • Q1 2025

    Question

    Ashwani Verma asked for thoughts on Shionogi's competing Fragile X program and its different endpoint, and also requested a breakdown of new WAKIX patients by prior oxybate experience.

    Answer

    Dr. Kumar Budur, CMSO, differentiated their program by noting it targets neurobehavioral symptoms prevalent in all Fragile X patients, unlike the competitor's focus on cognition in a subset of males. CCO Adam Zaeske explained that most new patients have prior therapy experience due to the market's polypharmacy nature. CEO Dr. Jeffrey Dayno added that concomitant WAKIX and oxybate use has been stable at 10-15%.

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    Ashwani Verma's questions to Harmony Biosciences Holdings Inc (HRMY) leadership • Q4 2024

    Question

    Ashwani Verma asked about emerging literature suggesting orexin agonists might accelerate Alzheimer's pathology and whether this is a concern for Harmony's program or the FDA.

    Answer

    Dr. Kumar Budur, Chief Medical and Scientific Officer, stated the concern was linked more to orexin 1 receptors and the effects of sleep deprivation itself, not the agonist. He clarified that this has not been observed in their preclinical models or in data from other ongoing clinical trials, and he does not consider it a current concern.

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    Ashwani Verma's questions to Harmony Biosciences Holdings Inc (HRMY) leadership • Q3 2024

    Question

    Ashwani Verma asked about the rationale for including non-complete methylation patients in the ZYN-002 RECONNECT study and inquired about potential inventory build given the divergence in sequential revenue and patient growth.

    Answer

    Chief Medical and Scientific Officer Dr. Kumar Budur explained that while the primary endpoint for ZYN-002 is in complete methylation patients, the inclusion of partially methylated patients was based on FDA discussions and could support a broader label. CFO Sandip Kapadia stated there was no significant inventory build, attributing the stronger revenue growth to typical second-half improvements in gross-to-net deductions.

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    Ashwani Verma's questions to Axsome Therapeutics Inc (AXSM) leadership

    Ashwani Verma's questions to Axsome Therapeutics Inc (AXSM) leadership • Q2 2025

    Question

    Ashwani Verma sought to understand the discrepancy between Auvelity's 15% sequential prescription growth and its 24% net sales growth, asking if inventory was the primary driver.

    Answer

    Chief Financial Officer Nick Pizzie explained that the difference was due to three factors: a slight improvement in the gross-to-net percentage (while still in the mid-50s range), an increase in inventory value due to higher demand (while still at the two-week level), and a small, favorable change of estimate from a prior quarter's liability accrual.

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    Ashwani Verma's questions to Axsome Therapeutics Inc (AXSM) leadership • Q1 2025

    Question

    Ashwani Verma of UBS asked how pursuing a supplemental NDA (sNDA) for AXS-05 in Alzheimer's disease agitation, rather than a new NDA, could impact the product's commercial potential, particularly concerning its gross-to-net (GTN) discount, which might be consolidated with the depression indication.

    Answer

    Ari Maizel, Chief Commercial Officer, explained that the sNDA pathway provides promotional clarity under the Auvelity brand name. He viewed this as beneficial, suggesting that existing payer familiarity with the product could facilitate access for the new indication. He did not see the GTN aspect as a necessary negative and expressed confidence in the commercial advantages of this strategy.

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    Ashwani Verma's questions to Neurocrine Biosciences Inc (NBIX) leadership

    Ashwani Verma's questions to Neurocrine Biosciences Inc (NBIX) leadership • Q2 2025

    Question

    Ashwani Verma of UBS Group asked about the typical duration of reimbursement authorizations for Crinesity and whether reauthorization requires demonstrating a specific level of steroid dose reduction.

    Answer

    CCO Eric Benevich stated that initial authorizations are typically for six or twelve months. For reauthorization, plans generally require the provider to affirm that the patient is benefiting from treatment, rather than mandating specific lab results or a hard threshold for glucocorticoid dose reduction. He described the reauthorization process as being as smooth as the initial authorization.

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    Ashwani Verma's questions to Neurocrine Biosciences Inc (NBIX) leadership • Q1 2025

    Question

    Ashwani Verma asked about the timing of the benefits from new INGREZZA Medicare contracts and requested a reminder of the sales force expansion size and when its impact would be realized.

    Answer

    Chief Commercial Officer Eric Benevich stated that pull-through efforts for the new formulary access began in April and primarily benefit new patient starts, and that the 'substantial' sales force expansion is now showing tangible benefits. CFO Matthew Abernethy clarified the financial timing: the negative gross-to-net impact is immediate in Q2, while the positive revenue impact from new patients will accrue over several quarters.

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    Ashwani Verma's questions to Neurocrine Biosciences Inc (NBIX) leadership • Q4 2024

    Question

    Ashwani Verma asked if the utilization management headwinds for INGREZZA are expected to worsen in 2025 for Medicare Part D plans due to the Inflation Reduction Act (IRA) causing plans to tighten controls.

    Answer

    Chief Commercial Officer Eric Benevich stated that they do not expect significant changes to INGREZZA's coverage in 2025 versus 2024. He also highlighted that Neurocrine has a 'small manufacturer' designation, which provides a phase-in benefit on the catastrophic coverage contribution under the IRA, a status shared by its competitor, so there is no relative disadvantage within the VMAT2 class.

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    Ashwani Verma's questions to Neurocrine Biosciences Inc (NBIX) leadership • Q3 2024

    Question

    Ashwani Verma of UBS asked for key learnings from the NBI-568 Phase II results, particularly regarding its orthosteric agonism, and the implications for the rest of the muscarinic pipeline.

    Answer

    CMO Eiry Roberts stated that the company is rapidly advancing NBI-568 into a Phase III registration program for schizophrenia in H1 2025, following encouraging Phase II data. She emphasized the potential for a selective agent to improve the benefit-risk profile in the space. She also noted the broader pipeline of M1 and M4 agonists will be evaluated for various indications as Phase I data becomes available.

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    Ashwani Verma's questions to United Therapeutics Corp (UTHR) leadership

    Ashwani Verma's questions to United Therapeutics Corp (UTHR) leadership • Q2 2025

    Question

    Ashwani Verma from UBS Group AG inquired about the TETON study design, specifically how patient discontinuations are handled statistically and whether the known side effect of cough from Tyvaso could lead to functional unblinding of the trial.

    Answer

    Dr. C.Q. Deng, SVP of Biostatistics, and Dr. Leigh Peterson, VP of Product Development, both addressed the question. Dr. Deng noted that placebo patients also experience cough, mitigating unblinding risk. Dr. Peterson added that deaths are penalized with a low FVC value (2.5th percentile), while other discontinuations are handled through statistical models like MMRM or multiple imputation.

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    Ashwani Verma's questions to United Therapeutics Corp (UTHR) leadership • Q1 2025

    Question

    Ashwani Verma from UBS Group AG asked for an update on Tyvaso patient additions in recent quarters and for the company's expectations regarding Insmed's upcoming TPIP data and Tyvaso's competitive positioning against it.

    Answer

    President and COO Michael Benkowitz stated that the company no longer provides specific patient-add metrics for competitive reasons but advised that revenue trends are a good proxy for underlying demand. Regarding TPIP, he noted they await the data, while CEO Martine Rothblatt expressed confidence in retaining well-managed patients and highlighted UTHR's own preclinical once-daily NCE as part of its 'multiple shots on goal' strategy.

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    Ashwani Verma's questions to United Therapeutics Corp (UTHR) leadership • Q4 2024

    Question

    Ashwani Verma questioned the potential competitive impact from Merck's sotatercept (Winrevair) following the Hyperion study and whether Tyvaso could maintain its growth in the PAH market.

    Answer

    Michael Benkowitz, President and Chief Operating Officer, asserted that sotatercept is an additive therapy, not a replacement for prostacyclins, and is often used in combination. He believes the long-term impact will be immaterial because PAH is a progressive disease, and patients will ultimately require a prostacyclin, maintaining the company's long-term growth prospects.

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    Ashwani Verma's questions to United Therapeutics Corp (UTHR) leadership • Q3 2024

    Question

    Ashwani Verma, also known as Ash Verma, asked if the company remains on track for its $4 billion revenue run rate goal in 2025 and whether it has preemptively initiated rebating ahead of a competitor's launch.

    Answer

    Executive Martine Rothblatt expressed confidence in reaching future revenue milestones by maintaining double-digit annual growth. Executive Michael Benkowitz confirmed that new Part D payer contracts have been initiated, with all expected to be effective by January 1. He noted this positions the company favorably for future competition by having established rebate flows and parity language.

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    Ashwani Verma's questions to Teva Pharmaceutical Industries Ltd (TEVA) leadership

    Ashwani Verma's questions to Teva Pharmaceutical Industries Ltd (TEVA) leadership • Q2 2025

    Question

    Ashwani Verma of UBS Group asked for a timeline on when the conversion from AUSTEDO BID to XR would be fully reflected across all patients and sought more detail on the P&L impact from tariffs, particularly regarding the exclusion of certain generics.

    Answer

    President and CEO Richard Francis explained that while new patients are favoring AUSTEDO XR, the full conversion will take time as stable patients are not always switched. He and EVP & CFO Eli Kalif reiterated that there is still too much uncertainty around the specifics of European tariffs to detail the P&L impact, but conservative planning is underway.

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    Ashwani Verma's questions to Alkermes Plc (ALKS) leadership

    Ashwani Verma's questions to Alkermes Plc (ALKS) leadership • Q2 2025

    Question

    Ashwani Verma from UBS Group asked about the specific time of day patients were dosed and whether the statement of no visual disturbance signal was based on AEs reported both during and outside of scheduled exams.

    Answer

    Marcus Yountz, VP of Clinical Development, stated that patients were instructed to take the dose in the morning around 8 AM. Richard Pops, Chairman & CEO, reiterated that specific AE data tables would not be available until the safety database closes in mid-August, with a full presentation at World Sleep in September.

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    Ashwani Verma's questions to Alkermes Plc (ALKS) leadership • Q3 2024

    Question

    Ashwani Verma questioned the company's commentary on stable inventory, suggesting a disconnect between reported sales and prescription script growth, and asked if there was any inventory build for LYBALVI, ARISTADA, or VIVITROL.

    Answer

    CCO Todd Nichols reiterated that inventory dynamics were consistent with expectations. He acknowledged that inventory for LYBALVI continues to grow modestly but stated this growth is consistent with and necessary to support the strong underlying demand and TRx growth. He concluded that inventory for both ARISTADA and LYBALVI is considered stable.

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    Ashwani Verma's questions to Exelixis Inc (EXEL) leadership

    Ashwani Verma's questions to Exelixis Inc (EXEL) leadership • Q2 2025

    Question

    Ashwani Verma from UBS asked if the positive ITT data from the STELLAR-303 trial could be presented at a medical conference this year, even while the final analysis for the second primary endpoint is still pending.

    Answer

    EVP & CMO Amy Peterson did not commit to a specific venue but confirmed they will share the data once abstract titles are public. She also affirmed that the company has a precedent for presenting positive results from one primary endpoint while another is still maturing.

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    Ashwani Verma's questions to Exelixis Inc (EXEL) leadership • Q1 2025

    Question

    Ashwani Verma asked for more detail on the NET launch dynamics, specifically from which existing therapies uptake would come and how CABOMETYX would compete with or be sequenced around Lutathera.

    Answer

    EVP of Commercial P.J. Haley reiterated that based on the unique and broad dataset, they expect CABOMETYX to be used broadly across lines of therapy and sites of origin. He stated the company's goal is to establish it as the small molecule leader within its approved indication, implying competition with other oral therapies.

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    Ashwani Verma's questions to Exelixis Inc (EXEL) leadership • Q4 2024

    Question

    Ashwani Verma asked if the efficacy level shown for zanzalintinib plus atezolizumab in CRC at ASCO GI is sufficient to support the company's broader peak sales guidance for the drug.

    Answer

    Chief Medical Officer Amy Peterson stated that the company is encouraged by the data, noting that the observed overall survival of 11.7 months 'bodes well' against the 6.5-7.5 months seen with regorafenib. She also highlighted strong survival data in the non-liver met population, while cautioning that a large, randomized Phase III study is required for confirmation.

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    Ashwani Verma's questions to Exelixis Inc (EXEL) leadership • Q3 2024

    Question

    Ashwani Verma questioned the company's capital allocation priorities, asking why the focus is on share buybacks now that IP uncertainty is resolved, rather than deploying most capital towards pipeline development.

    Answer

    President and CEO Michael Morrissey responded that with the company's strong cash flow and commitment to disciplined spending, it can pursue all priorities simultaneously. This includes investing in the pipeline, executing business development, and returning cash to shareholders.

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    Ashwani Verma's questions to Jazz Pharmaceuticals PLC (JAZZ) leadership

    Ashwani Verma's questions to Jazz Pharmaceuticals PLC (JAZZ) leadership • Q1 2025

    Question

    Ashwani Verma of UBS asked for clarification on the comment about one fewer shipping week, wanting to know if it affected specific products or the entire business.

    Answer

    Bruce Cozadd, Chairman and CEO, and Renée Galá, President and COO, both confirmed that the impact of having one fewer shipping week in the quarter was common across their U.S. oncology business.

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    Ashwani Verma's questions to Incyte Corp (INCY) leadership

    Ashwani Verma's questions to Incyte Corp (INCY) leadership • Q4 2024

    Question

    Ashwani Verma from UBS asked for Incyte's view on the potential impact of upcoming competitor readouts in hidradenitis suppurativa (HS), such as canakinumab and Rinvoq, on the value proposition for povorcitinib.

    Answer

    Pablo Cagnoni, President, Head of R&D, reiterated his confidence that povorcitinib has a very competitive profile. He stated that based on the totality of the Phase II data—including efficacy across multiple HiSCR levels, pain response, and safety—povorcitinib is well-positioned against biologics and Rinvoq, even with an expected correction from Phase II to Phase III results.

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