Ayan Hussein's questions to RIGEL PHARMACEUTICALS (RIGL) leadership • Q2 2025
Question
Ayan Hussein, on behalf of Kristen Kluska, asked for physician feedback on what level of transfusion reduction or independence is considered clinically meaningful for patients with lower-risk MDS.
Answer
EVP & Chief Medical Officer Lisa Rojkjaer explained that with current therapies achieving around 40% transfusion independence, a significant unmet need remains for the other 60% of patients. She stated that physicians would welcome any improvement on this rate, also noting that factors like a more convenient oral administration and a better toxicity profile represent opportunities for improvement.