Bill Morgan's questions to Fate Therapeutics Inc (FATE) leadership • Q1 2024
Question
Bill Morgan of Canaccord Genuity asked how the company thinks about translating PK data from oncology patients to autoimmune patients, considering the key role of antigen-dependent expansion for CAR-T therapies.
Answer
CEO Scott Wolchko conceded that much is still unknown about the translation between the two disease settings. While they have observed CD19-mediated, dose-dependent expansion, he does not presume the PK profiles will be identical. He stressed that the most critical endpoint is the kinetics and depth of B-cell depletion, which is the therapy's primary mechanism of action.