Boris Peaker's questions to Alpha Cognition (ACOG) leadership • Q2 2025
Question
Boris Peaker asked for details on the initial patient adopters of ZUNVAIL, the current gross-to-net discount and its expected evolution, and the timing for the next $3 million milestone payment from CMS.
Answer
COO Lauren D'Angelo described the initial patient types as roughly half switching from donepezil and half being new to therapy, with a third category emerging around behavioral symptoms. CEO Michael McFadden stated the gross-to-net is currently around $600 and will likely settle in the $575 to $625 range in coming quarters. He also confirmed the next CMS payment is expected in the last quarter of 2025.