Question · Q3 2025
Chi Eze asked for clarification on the severe vision blur reported in Vibrance I, including its duration and dose response relationship, and the specific dose levels where moderate and severe visual AEs occurred.
Answer
Richard Pops, CEO, clarified that most visual AEs were mild blurred vision, one moderate (resolved to mild), and one severe (part of a constellation of symptoms leading to early termination). He confirmed a dose response (more at 8mg) but noted no new incidents in the extension period for previously exposed patients, concluding that AEs are generally mild to moderate, transient, with insomnia and polycythemia as on-target effects.