Chi Fong's questions to Galapagos NV (GLPG) leadership • Q1 2025
Question
Chi Fong, on for Jason Gerberry, asked for the company's view on Parkinsonism as a class effect for BCMA-targeted therapies, the mitigation strategies used for GLPG5301, and whether any cases have been seen since the study resumed.
Answer
Clinical Program Head Omotayo Fasan stated that their mitigation strategy involves managing known risk factors like high tumor volume and rapidly rising lymphocyte counts. She confirmed that since restarting the study with these protocol amendments, they have been able to manage all enrolled patients and have not observed any further occurrences of Parkinsonism.