Chi Meng Fong's questions to FRACTYL HEALTH (GUTS) leadership • Q1 2025
Question
Chi Meng Fong of BofA Securities inquired about the specific timing for the REMAIN-1 midpoint analysis in Q3 and the expected effect size delta between the Revita and sham arms.
Answer
CEO Harith Rajagopalan confirmed confidence in the Q3 2025 timeline, noting that over 45 patients have already achieved the 15% weight loss threshold for randomization. He reaffirmed the company's goal is to demonstrate an effect at least 50% better than the weight regain expected from tirzepatide withdrawal alone, pointing to upcoming REVEAL-1 data as an early indicator.