Question · Q4 2025
Christopher Uhde asked about Calquence's growth prospects, specifically if the AMPLIFY regimen will significantly boost growth beyond current consensus estimates, and if there are other key events to unlock further growth.
Answer
Dave Fredrickson, EVP, Oncology Business Unit, AstraZeneca, confirmed AMPLIFY's importance for Calquence's growth, especially with anticipated US approval. He highlighted the trend towards finite therapies in hematology and Calquence's differentiated profile against venetoclax-based options. He also mentioned opportunities in ECHO for second-line MCL and DLBCL with Escalade.
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