Question · Q4 2025
Dina, on behalf of Jason Gerberry, asked if clinicians are more focused on a reduction in level 3 hypoglycemic events versus the regulatory composite endpoint, and for expectations on how events should skew at baseline between level 2 and level 3.
Answer
Co-CEO Josh Cohen explained that level 2 events signify severe symptoms and high risk of progressing to level 3 (incapacitation), which is why clinicians view both as critical and value the composite endpoint. He noted that previous studies showed slightly more level 2 than level 3 events, and they often occurred together.
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