Doug Lasalle's questions to SAGE Therapeutics Inc (SAGE) leadership • Q4 2024
Question
Doug Lasalle asked if management was surprised by the level of penetration with psychiatrists and what specific data from the upcoming SAGE-319 studies would provide confidence in the drug's activity beyond simple exposure.
Answer
CEO Barry Greene said they were not surprised, as the commercial strategy deliberately focuses on OB/GYNs who are at the front end of the patient journey. Regarding SAGE-319, CMO Laura Gault explained that the Phase 1 studies will use EEG to look for a specific brain activity signature that was observed in preclinical models. Confirming this differential signal in humans would provide evidence of the drug's unique mechanism of action.