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    Ethan Markowski

    Research Analyst at Needham & Company

    Ethan Markowski is an Equity Research Associate at Needham & Company, specializing in healthcare and biotechnology sector research with a focus on companies such as Precision BioSciences. Since joining Needham in May 2023, Markowski has contributed to industry conferences and supported research coverage for emerging life sciences firms. His career began as an Analyst at Destum Partners and continued with business development roles at Bayer before entering equity research, leveraging his clinical background as a PharmD graduate. Markowski holds a Doctor of Pharmacy degree from the University of Pittsburgh and brings a strong foundation in both healthcare sciences and financial analysis to his equity research position.

    Ethan Markowski's questions to Taysha Gene Therapies (TSHA) leadership

    Ethan Markowski's questions to Taysha Gene Therapies (TSHA) leadership • Q2 2025

    Question

    Ethan Markowski from Needham & Company questioned if Taysha expects any FDA pushback on using a six-month interim readout for a BLA filing, especially given a competitor's recent regulatory feedback.

    Answer

    CEO Sean Nolan stated that Taysha's interim analysis approach is highly data-driven, supported by robust Part A data showing a clear and significant effect at six months, with an 83% responder rate in the high-dose group. He confirmed that discussions with the FDA have been constructive and are focused on refining the analysis details, with no pushback received on the viability of the six-month interim itself.

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    Ethan Markowski's questions to Immunocore Holdings (IMCR) leadership

    Ethan Markowski's questions to Immunocore Holdings (IMCR) leadership • Q2 2024

    Question

    Ethan Markowski of Needham & Company asked if the PRAME strategy in endometrial cancer would mirror other indications by moving to earlier lines, and if KIMMTRAK's growth in Europe would be driven solely by new country launches.

    Answer

    Mohammed Dar, an executive, stated there are no current plans to move the endometrial program to earlier lines until more late-line data is generated. Ralph Torbay, Head of Commercial, confirmed that future European growth for KIMMTRAK will be marginal and primarily driven by new country launches due to the very tough reimbursement environment.

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    Ethan Markowski's questions to Immunocore Holdings (IMCR) leadership • Q2 2024

    Question

    Ethan Markowski of Needham & Company inquired if the PRAME strategy for endometrial cancer would mirror other indications by moving to earlier lines, and asked if KIMMTRAK's European growth will depend solely on new country launches.

    Answer

    Mohammed Dar, an executive, stated there are no current plans to move endometrial to earlier lines until late-line data is generated. Ralph Torbay, Head of Commercial, confirmed that future marginal growth in Europe will primarily be driven by launches in new countries, given the challenging reimbursement environment.

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