Evan

Evan inquired about potential strategies to accelerate the development timelines for RM-718, possibly through a Phase 2/3 design, and also asked if Rhythm Pharmaceuticals is exploring other areas of MC4R development or alternative approaches to treating obesity.

Answer

David Meeker, Chairman, CEO, and President, stated that RM-718 development would likely proceed directly to Phase 3 after an open-label study, similar to bivamelagon, and that while the company aims for speed, regulatory approaches can be conservative. He clarified that the urgency for RM-718 is different as setmelanotide will offer an option. Meeker confirmed interest in exploring other genetic indications with next-generation molecules and early programs for complementary MC4R approaches to obesity, but noted these are not yet ready for detailed discussion.

Evan, on behalf of Seamus Fernandez, asked about potential strategies to accelerate the development timelines for RM-718, such as a Phase 2/3 trial, given prior feedback and data from bivamelagon and setmelanotide. He also inquired if Rhythm Pharmaceuticals was exploring other areas of MC4R development or alternative approaches to treating obesity.

Answer

David Meeker, Chairman, CEO, and President, stated that while Rhythm Pharmaceuticals generally takes an aggressive view, regulators often prefer conventional approaches, making significant acceleration for RM-718 unlikely, especially since setmelanotide will be available for HO. He confirmed interest in expanding genetic indications with next-generation molecules (EMANATE, DAYBREAK) and exploring early-stage programs to complement MC4R, though details on other obesity approaches are not yet ready for discussion.

Evan from Stock Market News asked about Robinhood Social's targets for 2026 and whether its focus would be primarily on the U.S. or include international expansion.

Answer

Vlad Tenev, CEO, indicated that Robinhood Social would likely launch and scale in the U.S. first, benefiting from a dense network and integration with the existing platform. He expects eventual international expansion as translation technologies improve, allowing global customers to benefit from content.

Evan asked about Robinhood Social's targets for 2026 and whether the focus for its rollout would be primarily U.S. or international.

Answer

CEO Vlad Tenev indicated Robinhood Social would likely launch and scale in the U.S. first due to network benefits and integration, with international expansion expected later, especially as translation technologies improve.