Question · Q3 2025
Gina Wang inquired about potential concerns regarding acute pancreatitis (AP) events in the Olzarsen CORE and CORE 2 data to be presented at AHA, and asked for the peak revenue potential for Donzera, Olzarsen, and Alexander disease.
Answer
Brett Monia, CEO, assured there were no concerns regarding the AP data, describing it as groundbreaking with rapid and durable protection, and highlighted the pre-specified statistical plan for CORE and CORE 2. Kyle Jenne, Chief Global Product Strategy Officer, stated peak sales expectations: Donzera greater than $500 million, Olzarsen greater than $1 billion, and Zilganersen for Alexander disease greater than $100 million.