Question · Q3 2025
Hoyanon inquired about narcolepsy type two patients' hypersensitivity to exogenous orexin and the evidence suggesting lower hypersensitivity in NT2 patients compared to NT1.
Answer
Richard Pops, CEO, clarified that NT2 patients are less sensitive, not hypersensitive, to exogenous orexin-2 receptor agonists. He explained that NT1 patients, due to orexin deficiency, show significant efficacy at lower doses, while NT2 patients require and tolerate higher doses, indicating a dose response curve shift to the right.