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    Jason Dorr • Oppenheimer & Co. Inc.

    Jason Dorr's questions to Trevi Therapeutics Inc (TRVI) leadership

    Jason Dorr's questions to Trevi Therapeutics Inc (TRVI) leadership • Q2 2025

    Question

    Jason Dorr from Oppenheimer & Co. Inc. asked about the key topics to be addressed in the upcoming end-of-Phase 2 FDA meeting for Haduvio in IPF cough and requested details on the planned trial for non-IPF ILD chronic cough.

    Answer

    Chief Development Officer James Cassella outlined that the FDA meeting will focus on aligning on the Phase 3 protocol, dose selection, and the required safety database size. For non-IPF ILD, he noted the trial will include patients with various underlying fibrotic diseases. CEO Jennifer Good added that the company's strategy for the non-IPF ILD trial has evolved to a parallel arm design to potentially accelerate the program.

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    Jason Dorr's questions to Xeris Biopharma Holdings Inc (XERS) leadership

    Jason Dorr's questions to Xeris Biopharma Holdings Inc (XERS) leadership • Q2 2025

    Question

    Jason Dorr from Oppenheimer & Co. Inc. inquired about the evolution of the Gvoke treatment landscape over the next few years, especially concerning competitors, and requested more detail on the revenue outlook for the Gvoke VialDx collaboration with American Regent.

    Answer

    CEO John Shannon addressed the Gvoke landscape by highlighting the vast, underserved market of roughly 14 million at-risk diabetes patients who lack a ready-to-use glucagon. He sees the long-term opportunity as a collective effort with competitors to increase guideline adherence. Regarding Gvoke VialDx, he stated that more detailed guidance will be provided after the partner's launch later in the year, with minimal revenue impact expected in 2025.

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    Jason Dorr's questions to Xeris Biopharma Holdings Inc (XERS) leadership • Q1 2025

    Question

    Jason Dorr asked if management could provide a preview of the pivotal study design for the XP-8121 program ahead of the company's scheduled Investor Day.

    Answer

    CEO John Shannon declined to share early details, emphasizing the company's plan to present a complete and comprehensive overview of the product's opportunity, development plan, and study design all at once during the Analyst and Investor Day on June 3 to ensure the message is communicated clearly.

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