Jenna Li's questions to ADC Therapeutics SA (ADCT) leadership • Q2 2025
Question
Jenna Li from Jefferies, on behalf of Kelly Hsu, asked about the expected durability of the high complete response rates observed in the LOTUS-5 and LOTUS-7 trials. She sought clarity on the potential incremental durability benefit versus glufitamab monotherapy and what early durability metrics might be shared in the next LOTUS-7 update.
Answer
Chief Medical Officer Mohamed Zaki explained that high complete response (CR) rates are a strong surrogate for durability and noted that 25 of 26 CR patients in LOTUS-7 remained in response at the data cutoff. He mentioned both ZYNLONTA and glufitamab have shown significant durability as single agents. CEO Ameet Mallik added that future data updates will include updated Swimmer's plots and, as data matures, metrics on the median duration of CR at six and twelve months.