Lee Chen's questions to Coherus Oncology (CHRS) leadership • Q2 2025
Question
Asked for an update on the durability of response from the initial first-line HCC triplet study and inquired about the planned comparator arm for a future Phase III trial in the same indication.
Answer
The final data from the initial HCC study was presented in January, showing a 38% ORR, 17% CR, and durable responses, with an 8.9-month PFS. The ongoing study uses their own PD-1, Toripalumab. The next trial will likely be a Phase 2/3 study comparing their triplet against the standard of care, Atezo/Bev, with the decision informed by data expected in H1 2026.