Li Chen's questions to AFMD leadership • Q3 2024
Question
Asked about the development strategy for AFM28, including potential acceleration and positioning (frontline vs. later-line), and the rationale for choosing between unengineered NK cells versus CAR-NK cells for a combination therapy.
Answer
The company's preferred strategy for AFM28 is to first consolidate the monotherapy signal for a potential accelerated approval path in later-line AML, which is faster than a frontline trial. For combinations, they prefer using an allogeneic NK cell product over CAR-NKs, citing lower cost, simpler manufacturing, and the ability to recruit the patient's own NK cells for a dual attack.