Question · Q3 2025
Manoj Radder asked if Vibrance II top-line data would include time-course data (e.g., 4 vs. 8 weeks), the biological rationale for MWT deterioration seen in other studies, expected dose response in ESS for Vibrance II, and the desired PK profile for next-gen orexin-2 receptor agonists.
Answer
Richard Pops, CEO, stated that Alkermes does not expect to see tachyphylaxis or degradation in efficacy signal. He noted that top-line data might not include detailed time course but emphasized the potential competitive advantage of a range of doses. He declined to disclose specific PK attributes for next-gen orexins, describing them as 'different' for various patient populations.