Mark Forham's questions to PUMA BIOTECHNOLOGY (PBYI) leadership • Q2 2025
Question
The analyst inquired about the upcoming R&D data disclosures for the ELYSCA breast and lung trials, asking about the venue for the release, the clinical bar for advancing each program, and how the outcomes would affect the company's strategy for in-licensing additional products.
Answer
The CEO responded that the data would likely be released in a corporate update around November. The bar for advancement in the lung cancer trial is a significant Progression-Free Survival (PFS) and Overall Survival (OS) benefit, while the breast cancer trial requires a clear PFS benefit over endocrine therapy alone. He emphasized that regardless of the trial outcomes, the company will remain fiscally disciplined and prioritize profitability, only considering in-licensing opportunities that do not compromise their profitable status.