Question · Q3 2025
Mia Morgan inquired about the efficacy of Diraxonrasib combination treatment relative to monotherapy in frontline metastatic PDAC, and what to expect regarding durability updates in the first half of next year.
Answer
Wei Lin, Chief Medical Officer, explained that monotherapy and combination regimens test distinct hypotheses: sequential treatment introducing a third line of therapy versus potential synergy from combining Diraxonrasib with chemotherapy in the first line. Both strategies aim for survival benefit and offer different patient options. Mark Goldsmith, Chairman and CEO, confirmed that an update on the durability of effects for Diraxonrasib monotherapy and combination in first-line PDAC is expected in the first half of 2026.
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