Oliver McCammon's questions to Celcuity Inc (CELC) leadership • Q1 2025
Question
Oliver McCammon of LifeSci Capital asked for a review of the proof-of-concept data for targeting the PI3K/AKT/mTOR pathway in prostate cancer, the potential advantage of multi-node inhibition, and whether PSA data would be included in the upcoming Q2 update.
Answer
CEO Brian Sullivan reviewed data from AKT inhibitors in prostate cancer, noting their efficacy in P10-mutated patients. He contrasted this with nonclinical data showing gedatolisib's potency is independent of P10 status and significantly greater than single-node inhibitors, providing a strong rationale for the trial. Sullivan clarified that the upcoming Q2 update will focus on the primary analysis and safety data, with other data, such as PSA levels, to be presented at a future medical meeting.