Question · Q3 2025
Omar Rafat asked about the expected MWT benefit in the NT2 study, considering potential tachyphylaxis, and sought broad parameters on blinded safety data for NT2.
Answer
Richard Pops, CEO, declined to comment on blinded data but stated that based on phase 1b, orexin-2 receptor agonists can drive wakefulness in NT2 and idiopathic hypersomnia patients. He emphasized looking for clear evidence of safety, tolerability, and efficacy across dose ranges to inform phase three, noting no pretest hypothesis for tachyphylaxis.