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    Pete Stavropoulos

    Research Analyst at Cantor Fitzgerald

    Pete Stavropoulos is an Equity Research Analyst at Cantor Fitzgerald & Co., where he focuses on delivering actionable insights in the biotechnology sector by covering companies such as Arcturus Therapeutics and Jasper Therapeutics. With a documented track record that includes a 31.25% success rate and an average return of 2.61 stars on major analyst ranking platforms, Stavropoulos is recognized for his rigorous stock recommendations and sector expertise. He began his financial career as an Associate at H.C. Wainwright & Co. and ROTH Capital Partners, and has held research roles at The Rockefeller University, joining Cantor Fitzgerald in May 2018. Holding a doctorate from The Rockefeller University, Pete is further supported by his FINRA registrations and securities licenses, underscoring his professional credentials in equity research.

    Pete Stavropoulos's questions to Stoke Therapeutics (STOK) leadership

    Pete Stavropoulos's questions to Stoke Therapeutics (STOK) leadership • Q2 2025

    Question

    Pete Stavropoulos of Cantor Fitzgerald asked about any observed trends between seizure reduction and neurodevelopmental benefits, whether younger patients were driving improvements, and if the Phase 3 trial had enrollment caps based on age.

    Answer

    Interim CEO Ian Smith highlighted the trend of continued seizure reduction in lower-dose patients on the 45mg maintenance dose. SVP & Head of Neurology Kimberly Parkerson noted that correlating seizure and Vineland scores is difficult with the current sample size. She confirmed that benefits are seen across the 2-18 year age range, which is why the trial enrolls this spectrum without specific caps, though Ian Smith mentioned a slight loading towards ages 7-10.

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    Pete Stavropoulos's questions to Acumen Pharmaceuticals (ABOS) leadership

    Pete Stavropoulos's questions to Acumen Pharmaceuticals (ABOS) leadership • Q2 2025

    Question

    Pete Stavropoulos inquired about how new biomarker data informs Acumen's clinical strategy, whether they are monitoring blinded ARIA rates in the ALPITUDE study, and asked for details on the design of the blood-brain barrier candidate.

    Answer

    Chief Medical Officer Dr. Eric Siemers stated that while they monitor new biomarkers, their current panel (pTau217, Tau181, GFAP) is robust. On ARIA rates, he commented that blinded data has not been inconsistent with Phase 1 results. President & CDO Jim Doherty added that for the EBD technology, they are exploring various combinations of antibody cargo and JCR's carrier technology to optimize pharmacokinetics, brain penetration, and safety, with findings to be confirmed in preclinical studies, including a primate study.

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    Pete Stavropoulos's questions to Acumen Pharmaceuticals (ABOS) leadership • Q4 2024

    Question

    Pete Stavropoulos inquired how recent biomarker disclosures in the Alzheimer's field are shaping Acumen's clinical strategy, which key biomarkers might be emphasized in the ALTITUDE-AD data readout, and what to expect in the top-line results scheduled for late 2026.

    Answer

    Dr. James Doherty, President and Chief Development Officer, explained that the company is closely monitoring the rapid advancements in biomarkers, particularly P-tau217, and is biobanking samples for future analysis. Dr. Eric Siemers, Chief Medical Officer, reiterated that the primary endpoint is the clinical IADRS measure. CEO Daniel O'Connell clarified that top-line results will feature clinical endpoints, with biomarker data to be released subsequently.

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    Pete Stavropoulos's questions to Verastem (VSTM) leadership

    Pete Stavropoulos's questions to Verastem (VSTM) leadership • Q2 2025

    Question

    Pete Stavropoulos questioned the prescriber profile for AvmapKefaxin Jakobak, asking about the mix between targeted physicians, academic centers, and community settings, and how early traction compares to internal expectations. He also inquired about the company's experience with payers.

    Answer

    President and CEO Dan Paterson noted that traction has exceeded expectations, with prescriptions coming from a mix of Gyn-oncs and Med-oncs. Chief Commercial & Strategy Officer Michael Crowther added that uptake is balanced between top-tier customers and broader community physicians. Regarding payers, Paterson explained there has been no significant pushback, with reimbursement occurring for both on-label and off-label use, and the company's co-pay assistance program has been highly effective.

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    Pete Stavropoulos's questions to Harmony Biosciences Holdings (HRMY) leadership

    Pete Stavropoulos's questions to Harmony Biosciences Holdings (HRMY) leadership • Q2 2025

    Question

    Pete Stavropoulos of Cantor Fitzgerald asked about the RECONNECT study's primary endpoint, including potential variability, placebo mitigation measures, and key differences from the prior CONNECT study. He also asked the CCO about new levers to accelerate Wakix growth.

    Answer

    Chief Medical & Scientific Officer Dr. Kumar Budur detailed enhancements in the RECONNECT study, such as focusing on complete methylation patients and optimizing dosing, to increase the probability of success. EVP & CCO Adam Zaeske outlined his focus on improving top-line demand by increasing daily referrals, optimizing the conversion of referrals to dispenses, and enhancing patient retention through superior service.

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    Pete Stavropoulos's questions to Axsome Therapeutics (AXSM) leadership

    Pete Stavropoulos's questions to Axsome Therapeutics (AXSM) leadership • Q2 2025

    Question

    Pete Stavropoulos asked about adoption expectations for AXS-05 in Alzheimer's agitation, given Rexulti's uptake, and the planned strategy to drive adoption in various channels.

    Answer

    Chief Commercial Officer Ari Maizel stated that while they are watching the Rexulti launch, the key differentiator for AXS-05 is its combination of strong efficacy with a favorable safety and tolerability profile. He mentioned plans to leverage the Auvelity sales force and expand into geriatric psychiatry and long-term care facilities.

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    Pete Stavropoulos's questions to Mind Medicine (MindMed) (MNMD) leadership

    Pete Stavropoulos's questions to Mind Medicine (MindMed) (MNMD) leadership • Q2 2025

    Question

    Pete Stavropoulos from Cantor Fitzgerald asked for details on the powering assumptions and dropout rates for the VOYAGE and PANORAMA studies, and how the trial design, including the open-label extension (OLE), aims to generate data on real-world treatment patterns.

    Answer

    CEO Robert Barrow stated the trials are powered at 90% to detect a five-point difference on the HAM-A scale, assuming a 15% dropout rate. Chief Medical Officer Dr. Daniel Karlin added that the open-label extension (OLE) is a key feature to encourage retention and will help establish real-world treatment patterns by observing redosing needs over a full year.

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    Pete Stavropoulos's questions to Mind Medicine (MindMed) (MNMD) leadership • Q2 2025

    Question

    Pete Stavropoulos from Cantor Fitzgerald inquired about the statistical powering assumptions and dropout rates for the VOYAGE and PANORAMA studies, and also asked how the trial design aims to generate data on real-world treatment patterns.

    Answer

    CEO Robert Barrow stated the trials have 90% power to detect a five-point difference on the HAM-A scale, assuming a 15% dropout rate. CMO Dr. Daniel Karlin added that the open-label extension (OLE) is a key feature to improve retention and is designed to capture real-world retreatment patterns by allowing up to four doses per year, which they believe will establish the range of anticipated usage.

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    Pete Stavropoulos's questions to Voyager Therapeutics (VYGR) leadership

    Pete Stavropoulos's questions to Voyager Therapeutics (VYGR) leadership • Q4 2024

    Question

    Pete Stavropoulos asked about the key differences between tau silencing gene therapy and anti-tau antibodies, the potential for a combination approach, and how Voyager plans to establish human proof-of-concept for its capsid technology following the pause of the SOD1 program.

    Answer

    CMO Dr. Toby Ferguson explained that the IV-delivered tau silencing therapy aims for broad knockdown to remove existing tau, while antibodies aim to impede spread, suggesting they could be sequenced. He stated that human proof-of-concept for the capsid will now likely come from partnered programs with Neurocrine for Friedreich's ataxia and GBA, which have clear biomarker endpoints like frataxin and GCase levels.

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    Pete Stavropoulos's questions to Arcturus Therapeutics Holdings (ARCT) leadership

    Pete Stavropoulos's questions to Arcturus Therapeutics Holdings (ARCT) leadership • Q4 2024

    Question

    Pete Stavropoulos asked about the safety monitoring protocols for the ARCT-032 study, the patient characteristics in the ARCT-810 OTC deficiency trial, and what to expect from the interim data for the H5N1 vaccine study.

    Answer

    President and CEO Joseph Payne noted that the ARCT-032 study has a Data and Safety Monitoring Committee staffed by the CF Foundation's network, though specific safety thresholds were not disclosed. For ARCT-810, he confirmed the trial is enrolling younger and more advanced disease patients. For the H5N1 vaccine, he stated that interim data in H2 2025 will be a robust dataset covering immunogenicity across multiple doses and regimens in ~200 participants.

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    Pete Stavropoulos's questions to Arcturus Therapeutics Holdings (ARCT) leadership • Q3 2024

    Question

    Samantha, on behalf of Pete Stavropoulos, asked for an update on the H5N1 pandemic flu program, including key details and what to expect next.

    Answer

    CEO Joseph Payne confirmed that the company remains on track to initiate the clinical trial for its H5N1 pandemic flu vaccine this year. He noted the program's importance to its partner, BARDA, and mentioned that the relationship with the agency is being elevated.

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    Pete Stavropoulos's questions to Alector (ALEC) leadership

    Pete Stavropoulos's questions to Alector (ALEC) leadership • Q2 2024

    Question

    Asked about expectations for the upcoming TREM2 data, the bar for advancing the program, safety monitoring for ARIA, and details about the ABC technology's CD98 target.

    Answer

    The TREM2 data release will include clinical outcomes, safety, and key biomarker data. The bar for advancement is a combination of consistent clinical and biomarker signals, not just a p-value. ARIA incidence and severity have come down, and the LTE is exploring mitigation strategies. The CD98 target is expressed in various tissues, including endocrine glands and specific brain cells, which will be monitored for safety.

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    Pete Stavropoulos's questions to Alector (ALEC) leadership • Q2 2024

    Question

    Samantha, on behalf of Pete Stavropoulos from Cantor Fitzgerald, asked about expectations for the upcoming TREM2 data release, the bar for advancing the program, the status of ARIA-like safety observations, and details on the ABC technology's CD98 target.

    Answer

    Dr. Gary Romano, Chief Medical Officer, stated the data release will include top-line clinical, safety, and key biomarker data, with the bar for advancement being a consistent signal of slowing disease progression across these measures. He noted ARIA incidence has decreased and the LTE is exploring mitigation strategies. Dr. Arnon Rosenthal, CEO, and Dr. Sara Kenkare-Mitra, President, added that the CD98 target is expressed in various tissues, including the brain, and will be monitored for safety.

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    Pete Stavropoulos's questions to Eledon Pharmaceuticals (ELDN) leadership

    Pete Stavropoulos's questions to Eledon Pharmaceuticals (ELDN) leadership • Q1 2023

    Question

    Pete Stavropoulos of Cantor Fitzgerald inquired about the strategic rationale behind Sanofi's investment, the management of BK viremia in the upcoming BESTOW study, and the clinical benefits and measurement of steroid tapering in the trial.

    Answer

    CEO David-Alexandre Gros explained that Sanofi's investment was a standard financial one without any special rights, viewing Eledon as a good opportunity. President and Chief Scientific Officer Steve Perrin detailed that BK viremia is common and managed at the investigator's discretion by weaning immunosuppressants, with some flexibility for delaying Tegoprubart infusions. Perrin and Gros both highlighted that steroid tapering reduces significant side effects, improving patient quality of life, and will be compared across both arms of the study.

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    Pete Stavropoulos's questions to Eledon Pharmaceuticals (ELDN) leadership • Q4 2022

    Question

    Pete Stavropoulos of Cantor Fitzgerald inquired about the specifics of the upcoming data presentation for tegoprubart, asking about efficacy measures beyond eGFR, KOL feedback, the biological mechanism for creating a tolerogenic environment, the cause of new-onset diabetes post-transplant, and the steroid tapering protocol in the BESTOW study.

    Answer

    President and Chief Scientific Officer Steven Perrin explained the presentation will focus on eGFR data, as it is a highly predictable biomarker. He noted that while blocking CD40 ligand can induce regulatory T-cells, these changes are typically observed in tissue (via biopsy), not in circulation. He also clarified that new-onset diabetes is driven by CNI toxicity to pancreatic beta cells. CEO David-Alexandre Gros added that the BESTOW trial will aim to taper patients off steroids within a few months.

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    Pete Stavropoulos's questions to Eledon Pharmaceuticals (ELDN) leadership • Q3 2022

    Question

    Pete Stavropoulos of Cantor Fitzgerald inquired about the clinical significance of the IgA reduction observed in the ALS study for IgAN patients, the ideal target patient population for tegoprubart in IgAN, and the anticipated number of patients for whom data will be presented in the Q1 2023 updates.

    Answer

    President and Chief Scientific Officer Steve Perrin explained that while the double-digit IgA reductions in the ALS study were rapid and meaningful, their direct translation to IgAN is currently unknown. He and Chief Medical Officer Jeff Bornstein concurred that earlier intervention in IgAN is likely better to prevent irreversible kidney damage, though tegoprubart's dual upstream and downstream mechanism could benefit patients with significant inflammation. CEO David-Alexandre Gros added that the number of patients in the Q1 2023 data release will be comparable to initial Phase 2 readouts from other companies.

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