Question · Q3 2025
Rohit inquired about Mirum's perspective on the competitive dynamics in the PBC market, specifically in light of GSK's recent Linerixibat PDUFA announcement.
Answer
CEO Chris Peetz highlighted two key aspects: Volixibat's VANTAGE study incorporates both first and second-line PBC settings, including patients with stable alkaline phosphatase on UDCA but still experiencing itch, making them candidates for Volixibat. He also expressed excitement about Volixibat's competitive profile, citing the striking placebo-adjusted difference in itch observed in the VANTAGE interim data, which led to breakthrough designation.
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