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    Samantha Semenkow

    Vice President and SMid Biotech Equity Research Analyst at Citigroup Inc.

    Samantha Semenkow is a Vice President and SMid Biotech Equity Research Analyst at Citigroup, specializing in coverage of small- and mid-cap biotechnology companies. She covers firms such as 9 Meters Biopharma, Larimar Therapeutics, Sensei Biotherapeutics, Editas Medicine, Beam Therapeutics, and Cabaletta Bio, providing investment recommendations and price targets. With six years of experience at Citigroup, Semenkow has built a reputation for biotech equity research, yet her recent profile reflects a success rate of 31.5% and an average return of -13.7% based on performance metrics from analyst rating platforms. She holds relevant professional credentials with Citigroup Global Markets Inc. and is registered as a financial advisor, based in Getzville, NY.

    Samantha Semenkow's questions to Allogene Therapeutics (ALLO) leadership

    Samantha Semenkow's questions to Allogene Therapeutics (ALLO) leadership • Q2 2025

    Question

    Samantha Semenkow of Citi asked about the status of the protocol amendment to close the FCA arm, whether enrollment could continue, and if patients screened during the process would remain eligible.

    Answer

    CMO Dr. Zachary Roberts confirmed the protocol amendment is with IRBs and expected to be approved within days, causing minimal to no disruption. He assured that patients screened during this period will remain eligible for enrollment into the standard FC arm once the amendment is approved.

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    Samantha Semenkow's questions to Allogene Therapeutics (ALLO) leadership • Q1 2025

    Question

    Samantha Semenkow asked about the expected size of the initial ALLO-329 data set needed for a lymphodepletion decision and whether similar site staffing challenges from ALPHA3 are anticipated for the RESOLUTION study.

    Answer

    CEO David Chang acknowledged that based on the ALPHA3 experience, they are proactively addressing potential site staffing issues for the autoimmune trial, which has added logistical complexity. He indicated the initial data would come from a 'handful of patients' and that the study is designed to evaluate both lymphodepletion regimens (with and without) before making a selection.

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    Samantha Semenkow's questions to Allogene Therapeutics (ALLO) leadership • Q4 2024

    Question

    Samantha Semenkow from Citigroup asked how Allogene views the infrastructure build-out by autologous CAR-T competitors in community centers and how it could be leveraged for a potential cema-cel launch.

    Answer

    Dr. David Chang, President and CEO, characterized the expansion of CAR-T infrastructure into community centers as a positive development for the entire field. He asserted that allogeneic CAR-T is particularly well-positioned to benefit from this due to its logistical simplicity and scalability, which are significant advantages in the community setting.

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    Samantha Semenkow's questions to Allogene Therapeutics (ALLO) leadership • Q3 2024

    Question

    Samantha Semenkow asked if targeting CD70 via the Dagger technology could be a contributing factor to the Grade 5 events seen with ALLO-316 and how this safety profile might translate to the autoimmune program and influence dose selection.

    Answer

    Dr. David Chang, President and CEO, responded that while the Dagger technology enhances the CAR-T's pharmacodynamic effect, the safety events are highly confounded by the patients' advanced disease state. He stated there is not a direct read-through to the autoimmune population. The key to development, as with any active drug, is finding the right dose and lymphodepletion regimen to balance safety and efficacy, which will be a primary goal of the ALLO-329 Phase I study.

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    Samantha Semenkow's questions to CATALYST PHARMACEUTICALS (CPRX) leadership

    Samantha Semenkow's questions to CATALYST PHARMACEUTICALS (CPRX) leadership • Q2 2025

    Question

    Samantha Semenkow asked about Catalyst's strategy for educating oncologists on the LEMS opportunity for Firdapse, the metrics used to track the campaign's success, the expected timeline for oncology to become a larger revenue segment, and plans to leverage data from the Phase 1 DMD switching study for Agamry.

    Answer

    EVP & Chief Commercial Officer Jeff Del Carmen detailed a three-step oncology strategy involving frictionless VGCC antibody testing, leveraging new NCCN guidelines, and establishing care pathways in oncology practices. He noted success will be tracked by increased testing from oncologists, with a meaningful revenue impact expected in 2026 and beyond. Chief Medical Officer Dr. Will Andrews added that the Agamry switching study is exploratory, with data expected in late 2025 to early 2026 to inform potential future studies.

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    Samantha Semenkow's questions to CATALYST PHARMACEUTICALS (CPRX) leadership • Q3 2024

    Question

    Samantha Semenkow asked about early trends in AGAMREE's patient durability, the stability of the patient switch mix from EMFLAZA and prednisone, and the specific drivers behind the observed 15% discontinuation rate.

    Answer

    CCO Jeffrey Del Carmen reported a strong and stable discontinuation rate for AGAMREE of around 15%, which aligns with forecasts. He noted the patient switch mix (45% from EMFLAZA, 43% from prednisone) is also stable and expected to continue. Del Carmen clarified that discontinuations are often temporary pauses as patients evaluate new treatments like gene therapy, rather than being driven by efficacy or side effect concerns, and that patients are expected to return to AGAMREE.

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    Samantha Semenkow's questions to ARGENX (ARGX) leadership

    Samantha Semenkow's questions to ARGENX (ARGX) leadership • Q2 2025

    Question

    Samantha Semenkow from Citigroup asked about the rationale for advancing ARGX-119 into clinical development and whether the early data from the CMS study increases enthusiasm for its potential in larger indications like ALS and SMA, and what the overall market opportunity is.

    Answer

    CMO Luc Truyen explained that the CMS study was chosen to get the best 'proof of biology' for the agonistic MuSK antibody, which was successfully observed via functional improvements. CEO Tim Van Hauwermeiren added that while there is read-through potential, ALS and SMA are biologically different. He positioned ARGX-119 as a 'pipeline in a product' with exciting potential in nerve regeneration and muscle diseases beyond the current three indications.

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    Samantha Semenkow's questions to ARGENX (ARGX) leadership • Q1 2025

    Question

    Samantha Semenkow asked how the discontinuation rate in CIDP has trended and whether physicians are still commonly giving patients a 12-week trial period.

    Answer

    Chief Operating Officer Karen Massey confirmed that physicians are still largely using a 12-week trial period. She noted that as the launch has matured, the discontinuation rate has seen a slight uptick, moving closer to what was expected based on the ADHERE trial data. However, she emphasized that the rate remains below that level, indicating that patients are having a positive experience and staying on therapy.

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    Samantha Semenkow's questions to ARGENX (ARGX) leadership • Q4 2024

    Question

    Samantha Semenkow asked about the company's confidence in the FDA granting self-administration for the prefilled syringe (PFS) and how previous FDA concerns about the administration process factored into their strategy.

    Answer

    CEO Tim Van Hauwermeiren expressed confidence, stating that argenx submitted a 'very strong data set,' including a solid human factor study. He noted that based on the nature of questions from the FDA, the review appears to be on track for the April 10 PDUFA date, and the company is collaborating fully with the agency.

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    Samantha Semenkow's questions to ARGENX (ARGX) leadership • Q1 2024

    Question

    Samantha Semenkow asked if the highlighted growth in VYVGART Hytrulo was a recent acceleration and whether the prefilled syringe (PFS) is expected to have a similar or sharper uptake trajectory.

    Answer

    COO Karen Massey confirmed that Hytrulo uptake accelerated in Q1, driven by the establishment of payer policies and a J-code. She anticipates the PFS will be another significant growth engine, viewing it as a key advancement that will help move VYVGART into earlier lines of treatment and further expand the prescriber base.

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    Samantha Semenkow's questions to Wave Life Sciences (WVE) leadership

    Samantha Semenkow's questions to Wave Life Sciences (WVE) leadership • Q2 2025

    Question

    Samantha Semenkow from Citi inquired about the WVE-007 program, asking how the Activin E reduction in cohort one compared to preclinical models and about the expected correlation between knockdown and weight loss. For the AATD program, she asked about the target Z-to-M protein conversion rate.

    Answer

    President & CEO Paul Bolno explained that WVE-007 showed a dose response in preclinical models and that cohort one data demonstrated good consistency with their PK/PD modeling, which is why they expanded cohort two. For the AATD program (WVE-006), he stated the goal has always been to convert ZZ patients to an MZ phenotype, which they surpassed in the single-dose data. He noted that while they expect more protein with multi-dosing, achieving a 50% correction to the MZ level is the key therapeutic goal.

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    Samantha Semenkow's questions to Voyager Therapeutics (VYGR) leadership

    Samantha Semenkow's questions to Voyager Therapeutics (VYGR) leadership • Q4 2024

    Question

    Samantha Semenkow asked about the 'plug-and-play' potential of the ALPL non-viral shuttle for different molecules and what to expect from the preclinical data set anticipated later in the year.

    Answer

    CEO Dr. Al Sandrock explained that while some shuttles are 'plug-and-play,' different receptors like ALPL have unique properties that may be tailored to specific diseases, suggesting a future of more selective shuttles. He indicated the upcoming data would likely feature in vivo animal results, comparing ALPL to TFR-based shuttles and potentially demonstrating its utility with multiple payloads.

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    Samantha Semenkow's questions to SLRN leadership

    Samantha Semenkow's questions to SLRN leadership • Q3 2024

    Question

    Asked if the success bar for uveitis is 'better than Humira' and how the inclusion of biologic-experienced patients might impact study results.

    Answer

    Yes, the company is generally looking for a profile superior to adalimumab (Humira). The study includes biologic-experienced patients and stratifies for them at randomization to analyze their outcomes, acknowledging this is a difference from the original Humira trials which enrolled naive patients.

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    Samantha Semenkow's questions to SLRN leadership • Q2 2024

    Question

    Asked for an explanation of why the observed cases of tinnitus in the lonigutamab study were confined to Cohort 1 and whether there was a common factor among the affected patients.

    Answer

    The company has not identified a specific reason for the transient tinnitus cases in Cohort 1 and does not believe it is related to dose exposure, especially since it was not seen in Cohort 2. The cases were transient and resolved, and no patients experienced hearing impairment or audiogram changes.

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    Samantha Semenkow's questions to TSVT leadership

    Samantha Semenkow's questions to TSVT leadership • Q3 2024

    Question

    Samantha Semenkow inquired about apheresis rates in Q4 compared to Q3 and the expected trajectory into 2025, acknowledging the impact of seasonality mentioned in the guidance.

    Answer

    William Baird confirmed that while Q4 is impacted by holiday seasonality, the underlying demand since the third-line approval remains strong. He expressed encouragement with the growth seen in Q3 and stated they are working to support it commercially, with more details on 2025 to come later.

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    Samantha Semenkow's questions to TSVT leadership • Q4 2023

    Question

    Asked for insights on Abecma's utilization trends, the types of patients receiving it, and how physicians decide to use it versus other therapies.

    Answer

    The executive explained that utilization is highly site-specific and depends on what other therapies (other CAR-Ts, T-cell engagers) are available at a given center. They do not see Abecma being niched for a particular patient subset but rather used broadly.

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    Samantha Semenkow's questions to Beam Therapeutics (BEAM) leadership

    Samantha Semenkow's questions to Beam Therapeutics (BEAM) leadership • Q3 2024

    Question

    Samantha Semenkow from Citigroup inquired about the potential efficacy trade-off for the ESCAPE program if it proves safer but less effective than chemotherapy, and asked about safety concerns for the BEAM-103 (CD117 antibody) ahead of its healthy volunteer study.

    Answer

    CEO John Evans stated that based on current non-human primate data, they are achieving 'fairly full efficacy' with ESCAPE, mitigating concerns about a trade-off. President Dr. Giuseppe Ciaramella added that other anti-CD117 antibodies have shown a favorable safety profile with only mild, transient neutropenia, supporting the potential for an outpatient regimen and making a healthy volunteer study an efficient path to gather PK/PD data.

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    Samantha Semenkow's questions to Beam Therapeutics (BEAM) leadership • Q3 2024

    Question

    Samantha Semenkow of Citigroup Inc. asked about the potential efficacy versus safety trade-off for the ESCAPE platform and inquired about any known safety concerns related to targeting CD117 with the BEAM-103 antibody.

    Answer

    CEO John Evans stated that based on current data, they expect to achieve full efficacy with ESCAPE, avoiding a trade-off. President Dr. Giuseppe Ciaramella added that other studies with anti-CD117 antibodies have shown only transient, mild neutropenia, not myeloablation, suggesting a favorable safety profile that could even enable outpatient treatment.

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    Samantha Semenkow's questions to Beam Therapeutics (BEAM) leadership • Q3 2024

    Question

    Samantha Semenkow from Citigroup asked about the potential efficacy trade-off for ESCAPE's improved safety profile and inquired about any safety concerns with the BEAM-103 (anti-CD117) antibody.

    Answer

    CEO John Evans stated that initial NHP data for ESCAPE shows 'fairly full efficacy,' suggesting a compelling profile without a trade-off. President Dr. Giuseppe Ciaramella added that other anti-CD117 antibodies have shown only mild, transient neutropenia, supporting a favorable safety profile and the potential for an outpatient procedure. A healthy volunteer study will further define the PK/PD profile.

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    Samantha Semenkow's questions to Editas Medicine (EDIT) leadership

    Samantha Semenkow's questions to Editas Medicine (EDIT) leadership • Q2 2024

    Question

    Samantha Semenkow asked if the lipid nanoparticle (LNP) delivery system for the in vivo program's target tissue will be fully optimized by the POC readout, or if it will require further work afterward.

    Answer

    Chief Scientific Officer Linda Burkly explained that Editas is evaluating LNPs with multiple partners to target different tissues. She did not disclose the specific tissue for the upcoming POC but stated that information on the targeting aspect of the LNP would be shared when the data is released.

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    Samantha Semenkow's questions to Larimar Therapeutics (LRMR) leadership

    Samantha Semenkow's questions to Larimar Therapeutics (LRMR) leadership • Q1 2023

    Question

    Samantha Semenkow of Citi asked for updated thoughts on the variability of buccal cells versus skin, whether baseline frataxin levels were similar to Phase I, what level of frataxin increase would be considered clinically meaningful, and for more detail on the pharmacokinetic data regarding drug accumulation.

    Answer

    Dr. Carole Ben-Maimon, President and CEO, reiterated that skin is a less variable tissue than buccal cells but emphasized the importance of evaluating both. She confirmed baseline frataxin levels were similar to Phase I. Dr. Ben-Maimon explained that while a specific target for frataxin increase has not been set, it is not necessarily 50% of normal, as any increase could be beneficial. On pharmacokinetics, she clarified that the drug reached steady state by day 14 with no further accumulation, and exposure decreased proportionally with every-other-day dosing.

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