Shelby Tucker's questions to Allogene Therapeutics Inc (ALLO) leadership • Q2 2025
Question
Shelby Tucker, on for Luca Aci, asked if the recent patient death in the first-line setting, though likely related to the discontinued FCA arm, could materially slow trial enrollment given the patient was in a relatively stable state.
Answer
Zachary Roberts, CMO, explained that stakeholders, including the FDA and investigators, view MRD-positive patients as having chemo-refractory cancer at high risk of progression, making trial participation appropriate. He acknowledged the event's significance, which prompted a data review that ultimately reinforced confidence in moving forward with the FC arm, a decision supported by investigators.