Tim Chiang's questions to IDEAYA Biosciences (IDYA) leadership • Q1 2022
Question
Tim Chiang asked if establishing an MTD is a requirement for the GSK opt-in and requested more details on the expanded collaboration with Pfizer for darovasertib.
Answer
CEO & President Yujiro Hata clarified that the opt-in trigger is the selection of an expansion dose, not necessarily the MTD. He then detailed the two new Pfizer agreements: one enabling a potential registrational trial for darovasertib in metastatic uveal melanoma, and a second for exploring the combination with crizotinib in other cMET-driven tumors.