Tony Ren's questions to Takeda Pharmaceutical Co Ltd (TAK) leadership • Q3 2025
Question
Tony Ren of Macquarie Group asked for more detail on the Entyvio gross-to-net adjustment and its impact on the product's 11% CER growth guidance. He also inquired how Otezla's inclusion in IRA price negotiations affects plans for zasocitinib.
Answer
Executive Milano Furuta confirmed the adjustment was for U.S. government pricing and acknowledged it could make the 11% growth target for Entyvio challenging. CEO Christophe Weber stated that Otezla's IRA inclusion reinforces their strategy to highly differentiate zasocitinib on efficacy and safety versus existing oral treatments.