Question · Q4 2025
Yasmin Rahimi (Piper Sandler) inquired about the specific key milestones and their contingencies for Prothena's partnered programs, PARAISO and CLEOPATTRA, expected in 2026 and 2027, given their primary completion dates are anticipated in 2029.
Answer
Gene Kinney, President and CEO, highlighted upcoming scientific presentations on CYTOPE technology and the TDP-43 CYTOPE program in 2026. He also pointed to the expected data from Bristol Myers Squibb's tau program (BMS-986446) Phase 2 trial in the first half of 2027, emphasizing its tau PET primary outcome. Tran Nguyen, Chief Strategy Officer and CFO, added that Prothena anticipates up to $105 million in clinical milestones from partners in 2026, tied to coramitug and PRX019 advancements, and confirmed plans for a share redemption program in 2026.
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