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John A. Donofrio, Jr.

Chairman of the Board of Directors at AYTU BIOPHARMAAYTU BIOPHARMA
Board

About John A. Donofrio, Jr.

Independent director and Chairman of the Board at Aytu BioPharma since November 2024; joined the Board in July 2016. Age 58. Senior pharmaceutical executive with 30+ years across CFO/COO/President roles; founder of Riverside Consulting LLC. Holds an Accounting degree from North Carolina State University; designated the Board’s audit committee financial expert. Independent under Nasdaq listing rules .

Past Roles

OrganizationRoleTenureCommittees/Impact
Novan, Inc. / EPI Health (subsidiary)EVP & COO (Novan); President (EPI Health); President of EPI Health (pre-acquisition)Mar 2019 – Mar 2022 (EPI Health); subsequent at NovanLed operations and subsidiary integration; specialty dermatology focus
TrialCard (now Mercalis)CFO & Head of Business DevelopmentMar 2018 – Mar 2019Finance leadership; BD for patient access/services platform
Merz North AmericaCFO & Head of NA Business DevelopmentAug 2013 – Mar 2018Accountable for performance, cost mgmt, BD, strategic planning
GlaxoSmithKline (Stiefel)VP, Stiefel Global Finance (U.S. Specialty Business & Puerto Rico)Jul 2009 – Jul 2013Finance strategy and control framework for Global Dermatology BU
Vyrix PharmaceuticalsDirectorFeb 2014 – Apr 2015Board oversight at predecessor entity to Aytu
Riverside Consulting LLCFounderPost-2022Strategic and financial advisory to life sciences

External Roles

OrganizationRolePublic Company?Notes
Riverside Consulting LLCFounderNoAdvisory firm; no disclosed AYTU transactions .
Other public company directorshipsNone disclosed beyond AYTU .

Board Governance

  • Current roles: Chairman of the Board (appointed Nov 2024) .
  • Committee assignments: Audit Committee Chair; member of Compensation Committee; member of Nominating & Governance Committee .
  • Independence: Independent under Nasdaq rules; Audit Committee members meet SEC/Nasdaq independence standards .
  • Financial expertise: Designated audit committee financial expert (Item 407(d)(5)) .
  • Attendance: Board held 12 meetings in FY2025; each director attended at least 75% of Board and committee meetings .
  • Committee activity: Audit Committee met 6 times; Compensation Committee met once; Nominating & Governance Committee met once (FY2025) .

Fixed Compensation

Component (Non-Employee Director Policy effective 7/1/2025)AmountNotes
Board Chair or Lead Independent Director cash retainer$80,000Annual
Director cash retainer (other directors)$50,000Annual
Audit Committee Chair fee$20,000Annual
Compensation Committee Chair fee$20,000Annual
Nominating & Governance Committee Chair fee$10,000Annual
Audit/Comp Committee member fee$10,000Per committee, annual
Nominating & Governance Committee member fee$5,000Annual
John A. Donofrio, Jr. (FY ended 6/30/2025)AmountDetail
Fees earned or paid in cash$115,000Chair retainer ($80k) + Audit Chair ($20k) + Comp member ($10k) + N&G member ($5k)
Stock awards (grant-date fair value)$2,760Annual director equity grant
Total$117,760

Performance Compensation

  • Equity structure for directors: 6,500 restricted shares/RSUs upon appointment; annual 10,000 restricted shares/RSUs thereafter .
  • Vesting terms for director grants: Not specifically disclosed; general employee equity uses 3-year schedules, but no director-specific vesting detail provided—no inference made .
Performance Metrics Tied to Director CompensationDisclosed?
Financial/operational targets for director payNone disclosed .

Other Directorships & Interlocks

  • Investor-affiliated director on Board: Abhinav “Abi” Jain appointed via Nantahala’s designation right (Securities Purchase Agreement); Jain serves on boards of Talphera, Xtant Medical, Eagle Pharmaceuticals (potential investor interlock on Board; not a Donofrio conflict) .
  • No shared directorships or supplier/customer interlocks disclosed for Donofrio .

Expertise & Qualifications

  • Deep finance and operations expertise: consolidated reporting, international accounting/controls, systems, cost accounting, inventory, supply chain, transfer pricing, M&A integration, BD .
  • Board skills matrix: financial analysis/accounting, pharma industry, strategic planning, M&A/BD among Donofrio’s attributes .
  • Audit committee financial expert designation underscores governance and oversight capability .

Equity Ownership

HolderTotal Beneficial Ownership% of Shares OutstandingBreakdown
John A. Donofrio, Jr. (as of 10/13/2025)13,962 shares<1%2,623 common; 11,139 unvested restricted shares; 200 vested options (included)
Unvested restricted shares (as of 6/30/2025)2,890 sharesFiscal year-end status prior to annual grant
  • Anti-hedging/pledging: Company prohibits hedging, margin accounts, and pledging of Company stock by Section 16 Reporting Persons; all are in compliance—reduces alignment risk from hedging/pledging .

Governance Assessment

  • Strengths:

    • Independence and leadership: Independent Chair with audit chair responsibilities; designated financial expert—supports robust oversight of financial reporting, auditor independence, and related-party reviews .
    • Attendance and engagement: Board and committee cadence with minimum 75% attendance met; Audit met six times—active oversight .
    • Pay structure: Cash retainer plus modest equity aligns with standard small-cap biopharma governance; committee fee mix reflects workload and accountability .
  • Potential risks/flags:

    • Ownership alignment: Donofrio’s beneficial stake is <1%, with low grant-date equity value in FY2025 ($2,760)—alignment exists but is limited in magnitude for a Chair; note subsequent increase in unvested restricted shares post year-end .
    • Board composition consideration: Presence of investor-affiliated director (Jain via Nantahala designation) can create investor influence dynamics; mitigated by overall Board independence and committee structures .
    • Related party exposure: None disclosed for Donofrio; broader company-related party includes sibling executives (CEO and CBO); Audit Committee charter assigns related-party review to committee chaired by Donofrio—appropriate governance control .
  • Net view: Donofrio’s independent status, financial expertise, and committee chairmanships support board effectiveness and investor confidence. Ownership is modest—ongoing monitoring of annual equity grants and actual attendance trends remains prudent .