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Laura Bessen, M.D.

Director at C4 Therapeutics
Board

About Laura Bessen, M.D.

Independent Class I director since August 2022; age 62 as of April 2025; current term expires at the 2027 annual meeting. Background: Managing Partner at Maxsam Advisors, LLC; prior senior medical leadership at Bristol-Myers Squibb (Vice President, Head of U.S. Medical, 2001–2016) and Medical Director at DuPont Pharmaceuticals (1997–2001). Education: B.S. in Biochemistry (SUNY Binghamton) and M.D. (NYU School of Medicine) .

Past Roles

OrganizationRoleTenureCommittees/Impact
Bristol-Myers Squibb Co.Vice President, Head of U.S. Medical2001–2016 Senior U.S. medical leadership; pharma operating experience
DuPont PharmaceuticalsMedical Director1997–2001 Medical affairs leadership

External Roles

OrganizationRoleTenureNotes
Maxsam Advisors, LLCManaging PartnerCurrent Strategic clinical and medical affairs advisory
Artiva Biotherapeutics, Inc.DirectorSince March 2022 Oncology company; committee roles not disclosed
Other public company boardsDirectorCount: 1 (as of 2025) Company name not specified in proxy

Board Governance

  • Independence: Board determined all directors except CEO Andrew Hirsch are independent under Nasdaq and SEC rules; Laura Bessen is independent (Y) .
  • Class/Term: Class I; term expires 2027; director since 2022 .
  • Committees: Member, Nominating & Corporate Governance Committee (NCGC; chair: Ronald Cooper); Member, Science & Technology Committee (STC; chair: Donna Grogan) .
  • Attendance & engagement:
    • Board met 7 times in 2024; all directors attended ≥75% of Board and committee meetings; all directors in office attended the 2024 annual meeting .
    • NCGC met 7 times in 2024 (Bessen served); NCGC members are independent .
    • STC met 4 times in 2024 (Bessen served) .
  • Governance safeguards: Independent director executive sessions at least annually per Corporate Governance Guidelines .
Committee/Meeting20232024
NCGC meetings4 7
STC meetingsn/d4
Board meetingsn/d7; all directors ≥75% attendance; annual meeting attendance confirmed

Fixed Compensation

Metric20232024
Fees Earned or Paid in Cash ($)$49,000 $49,000
NotesBoard retainer $40,000; NCGC non-chair $4,000; STC non-chair $5,000 per 2023 policy Same structure applicable in 2024 (policy in effect pre-March 2024 update)

Director cash/committee retainer policy (comparative):

Retainer TypeMarch 2024 PolicyMarch 2025 Policy
Board retainer (non-employee)$40,000 $40,000
Chairman of the Board (additional)$30,000 $30,000
Lead Independent Director (additional)$25,000 $25,000
Audit Committee – Chair / Member$15,000 / $7,500 $15,000 / $7,500
OLCC – Chair / Member$10,000 / $5,000 $12,000 / $6,000
STC – Chair / Member$10,000 / $5,000 $12,000 / $6,000
NCGC – Chair / Member$8,000 / $4,000 $10,000 / $5,000

Performance Compensation

Metric20232024
Option Awards ($ grant-date fair value)$66,409 $131,625
Annual Option Grant – shares (policy)26,000 shares (continuing director) 32,500 shares (continuing director)
Initial Option Grant – shares (policy)52,000 shares (new director) 65,000 shares (new director)
Vesting – initial grant (policy)33% at 1st anniversary; remainder vests quarterly over next 2 years Same; increased initial grant to 65,000 in Mar 2024 update
Vesting – annual grant (policy)Fully vests by earlier of 1st anniversary or next annual meeting Fully vests by earlier of 1st anniversary or next annual meeting; annual grant size raised to 32,500 in Mar 2024; further to 35,500 in 2025
Exercise Price (policy)Fair market value on grant date Fair market value on grant date

No director PSUs/RSUs or performance metrics (TSR, EBITDA, ESG) for director pay are disclosed; director equity is exclusively stock options under the Non-employee Director Compensation Policy .

Other Directorships & Interlocks

  • Other public company boards: 1 (as of 2025 skills matrix) .
  • Board-level interlocks: Ronald H. W. Cooper (Chairman) previously held senior roles at Bristol-Myers Squibb (1985–2014), aligning with Bessen’s prior BMS tenure; network overlap can facilitate information flow but is not a related-party transaction per disclosures .

Expertise & Qualifications

  • Deep biopharma medical leadership and operations across large-cap pharma (BMS) and earlier-career medical affairs (DuPont) .
  • STC membership evidences R&D oversight capability; NCGC membership indicates governance/process proficiency .
  • Skills matrix: Industry expertise; Research & Development experience; Public company governance; Operations experience; Independent; Tenure ~2 years as of 2025 .

Equity Ownership

Ownership Detail (as of Apr 22, 2025)Value
Shares Beneficially Owned96,249 (options exercisable within 60 days)
% of Shares Outstanding<1% (outstanding shares: 71,007,083)
Options Outstanding (Dec 31, 2024)99,700
Shares pledged/hedgedProhibited by insider trading policy (short sales, hedging, pledging, margin collateral)

Footnote clarifies Bessen’s beneficial ownership comprises options exercisable within 60 days; no direct common shares are disclosed .

Governance Assessment

  • Committee roles and engagement: Active on NCGC (7 meetings in 2024) and STC (4 meetings), with Board attendance thresholds met and annual meeting participation—signals strong engagement and governance contribution .
  • Independence and conflicts: Board affirms independence; no related-party transactions involving Bessen since Jan 1, 2023; Audit Committee oversees a formal related-person transactions policy—low conflict risk .
  • Pay-for-performance alignment (director context): Director equity is all options with market-based exercise price and standard vesting; her 2024 option grant value increased versus 2023 alongside policy increases—equity-centric mix aligns interests, though lack of direct share ownership may temper “skin-in-the-game” optics .
  • Ownership alignment: Beneficial ownership solely via options (no disclosed common shares); options outstanding of 99,700 as of year-end—alignment exists through option leverage but limited direct share ownership is a potential investor perception risk .
  • Safeguards: Robust anti-hedging/pledging policy and clawback (executive compensation recovery) frameworks bolster governance confidence; Say-on-Pay support at ~74% in 2024 indicates mixed but acceptable investor sentiment toward compensation programs broadly .

RED FLAGS / Watch items

  • Low direct share ownership (beneficial stake comprised of options) may be viewed as weaker long-term alignment compared to meaningful common share holdings .
  • Classified board structure persists (Class I–III staggered terms); while common among early-stage biotech, investors may prefer declassification over time .

Net view: Bessen’s independence, committee service (NCGC/STC), and consistent attendance underpin governance effectiveness. Option-only equity for directors aligns to performance via future share price, but minimal disclosed common share ownership is a soft alignment concern. Overall conflict risk appears low given formal policies and absence of related-party ties involving Bessen .