Total Revenue

Down 25% from $54.59M in Q1 2024 to $41.04M in Q1 2025

Total Revenue declined sharply primarily because the strong performance of Life Sciences Services in Q1 2024 was not sustained in Q1 2025, and the modest 2% growth in Life Sciences Products revenue did not compensate for the drop in service revenue. " " "

Life Sciences Services Revenue

Down 38% from $36.79M in Q1 2024 to $22.87M in Q1 2025

The 38% YoY decline in this segment indicates a significant drop in demand or operational issues compared to the previous period, which heavily impacted overall revenue. " " "

Life Sciences Products Revenue

Up 2% from $17.81M in Q1 2024 to $18.18M in Q1 2025

Despite overall revenue challenges, Life Sciences Products revenue grew modestly, suggesting relative market stability for these products even as services lagged. " " "

Americas Revenue

Up 8% from $29.90M in Q1 2024 to $32.20M in Q1 2025

The Americas region saw moderate growth, reflecting potential market share gains and stronger performance in this territory compared to others. " " "

EMEA Revenue

Down 64% from $15.61M in Q1 2024 to $5.58M in Q1 2025

A 64% decline in EMEA revenue signals significant regional market contractions or operational challenges impacting performance in that region. " " "

APAC Revenue

Down 64% from $9.08M in Q1 2024 to $3.27M in Q1 2025

Similar to the EMEA region, APAC experienced a 64% drop, indicating severe challenges or a dramatic contraction in demand within the APAC market. " " "

Net Loss

Improved by 36% from $(18,895)K in Q1 2024 to $(11,981)K in Q1 2025

The 36% improvement in net loss suggests enhanced cost controls or lower expenses relative to prior losses, even though the operating segments experienced volatile revenue. " "

Net Loss Per Share

Improved from $(0.43) in Q1 2024 to $(0.28) in Q1 2025

The improvement in net loss per share mirrors the overall net loss improvement, reflecting better earnings efficiency on a per-share basis. " "

Cash and Cash Equivalents

Down 27% from $49,663K in Q1 2024 to $36,102K in Q1 2025

A 27% decline in cash suggests the company used a significant portion of its cash reserves in operations or investments during Q1 2025, which contrasts with higher cash reserves in the prior period. " "

Short-term Investments

Down 48% from $398,881K in Q1 2024 to $207,929K in Q1 2025

The nearly 48% decrease in short-term investments reflects a substantial portfolio reallocation and/or maturity of investments, resulting in a lower balance compared to Q1 2024. " "

Total Assets

Down 26% from $942,849K in Q1 2024 to $699,844K in Q1 2025

A 26% reduction in total assets indicates an overall downsizing of the asset base, possibly due to asset sales, depreciation, or restructuring measures that differ from the previous period’s balance. " "

Net Cash Used by Operating Activities

Not directly compared (Q1 2025 reported $(4,342)K along with an overall net cash increase of $2,072K)

While Q1 2025 shows net cash used by operating activities of $(4,342)K, the overall net increase in cash of $2,072K suggests that financing or investing activities helped offset operating cash outflows. No direct YoY comparison is available, but the Q1 2025 performance indicates a shift in cash management compared to Q1 2024. "

Revenue Guidance

FY 2025

$240 million to $250 million "

no guidance provided

no current guidance

Gross Margin

FY 2025

55% gross margin " "

no guidance provided

no current guidance

Adjusted EBITDA

FY 2025

positive adjusted EBITDA during FY 2025 " " "

no guidance provided

no current guidance

Commercial Revenue Growth

FY 2025

high 20% range "

no guidance provided

no current guidance

Cell and Gene Therapy Approvals

FY 2025

23 BLA/MMA filings in FY 2025, up from 11 in FY 2024 "

no guidance provided

no current guidance

Life Science Services and Cell & Gene Therapy Growth

Across Q2, Q3, and Q4 2024, Cryoport consistently highlighted strong double‐digit growth, expanding revenue share (up to 67% in Q4 " ), increasing clinical trial participation (up to 701 trials " " ), and rising commercial approvals in the Cell & Gene therapy space ( " " " ).

In Q1 2025, Life Science Services revenue grew 17% YoY and commercial Cell & Gene therapies grew 33% YoY; Life Science Services now account for 56% of total revenue with continued pipeline expansion ( " " " ).

Consistent positive momentum with strengthened revenue metrics and an increasingly robust clinical pipeline.

Cost Reduction Initiatives and Margin Improvement

In Q2, Q3, and Q4 2024, Cryoport discussed aggressive cost reduction measures—achieving annualized savings of around $22 million (Q2 " ), improvements in adjusted EBITDA and gross margins (up to 46% in Q3 " " ), and enhanced cost management leading to margin expansion in Q4 ( " " ).

Q1 2025 focused on supply chain initiatives to mitigate tariffs, applying surcharges where needed, and reported significant year‐over‐year increases in service gross margins—even while noting that new initiatives might temper short‐term margin growth ( " " " ).

A steady emphasis on cost control continues, with Q1 adding a focus on tariff management and margin protection—reinforcing a long‐term improvement narrative.

Regulatory Oversight and Approval Risk

Q2 2024 did not address regulatory risks; Q3 2024 had no discussion on this topic; and in Q4 2024, management pointed to robust review activity (for example, a customer’s BLA receipt and setting of a PDUFA date " ).

Q1 2025 detailed the new FDA leadership with a conservative stance, noting potential stricter oversight but reinforcing that strong scientific data will guide approvals; also, past U.S. policy support for Cell & Gene therapies was emphasized ( " ).

From minimal discussion to a more nuanced regulatory focus in Q1, reflecting increased attention to regulatory caution yet balanced by optimistic outlooks.

Supply Chain Resilience and Tariff Management

Q2 and Q3 2024 documents did not raise this topic, while in Q4 2024 the company described passing tariff impacts through surcharges and maintaining robust margins ( " ).

In Q1 2025, Cryoport expanded on its diversification efforts, detailed proactive supply chain routing changes and surcharges to offset tariffs, and noted that most products manufactured in the U.S. are tariff‐free ( " " " ).

Consistent strategic focus with enhanced operational details in Q1 that build on earlier measures, reinforcing supply chain resilience.

Strategic Partnership with DHL

There was no mention of a strategic partnership with DHL in Q2, Q3, or Q4 2024.

Q1 2025 announced DHL’s acquisition of CRYOPDP for $195 million, stressing its benefits for global expansion (especially in Asia Pac and EMEA), capital infusion, and improved competitive positioning—with no significant integration challenges mentioned ( " " ).

A new and positive strategic development providing additional capital and global scale, marking an upward shift in the narrative.

Pipeline Innovation and Revenue Development

In Q2 2024, the IntegriCell platform was introduced with facilities opening by end‑Q2; Q3 2024 noted inaugural contracts for IntegriCell and progress on the HV‑3 Shipping System with positive market feedback; Q4 2024 further elaborated on IntegriCell’s long‑term revenue potential and detailed the HV‑3 launch ( " " " " ).

Q1 2025 emphasized smooth progress in IntegriCell with operational facilities in Houston and Liege now active, multiple commercial contracts underway, and robust early market reception for the HV3 Shipping System, forecasting increased revenue over the coming quarters ( " " " ).

Ongoing innovation with steadily improving adoption; the advanced stage of both platforms signals strong future revenue development.

Revenue Guidance and Outlook Uncertainty

In Q2 2024, full‑year revenue guidance was revised to $225–$235 million amid softness in product demand and extended market recovery concerns; Q3 2024 maintained similar guidance while emphasizing cost realignment; Q4 2024 provided actuals (around $228.4 million) without explicit forward guidance ( " " " ).

In Q1 2025, guidance for fiscal year 2025 was set between $165–$172 million (a 7.5% growth from FY2024), with an expectation of strong growth in the services sector despite caution regarding tariffs and muted trends in China ( " " ).

While previous periods centered on stabilizing guidance, Q1 introduces a cautious yet positive outlook for FY2025, highlighting growth in services amidst ongoing uncertainties.

Regional Demand Weakness (Cryogenic Products, China)

In Q2 2024, China’s demand was very weak (around 3–4% contribution) with forecasts of prolonged weakness; Q3 2024 highlighted significant downturns in China with strategic adjustments discussed; Q4 2024 focused on diminished presence (<3%), implementing a "China For China" strategy and no recovery assumed in guidance ( " " " ).

Q1 2025 mentioned that China was not factored into guidance and confirmed that there was no expectation of meaningful demand destruction from tariffs or trade issues, suggesting muted trends remain ( " ).

Persistent regional weakness in China continues, with earlier discussions refined into a strategy of exclusion from guidance and ongoing caution.

Declining Emphasis on MVE Business Performance

Q2 2024 emphasized softening demand and excess capacity in the MVE business with lowered revenue expectations and a focus on recovery beyond 2024; Q3 2024 detailed depressed demand—especially in cryogenic freezers—alongside profitable margins and plans for recovery; Q4 2024 shifted to noting order stability and steady performance with no further decline ( " " " ).

Q1 2025 did not mention declining performance in the MVE business, suggesting a reduced emphasis or that the focus has shifted towards other core initiatives ( " ).

Earlier periods were marked by concerns and a critical review of MVE performance; the current period shows a diminished focus, indicating a strategic deprioritization as attention shifts to growth drivers.