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Sanford Zweifach

Director at ESSA Pharma
Board

About Sanford Zweifach

Sanford Zweifach has served as an independent director of ESSA Pharma Inc. since July 31, 2019, with a 30-year biotechnology career spanning operating and investment roles. He holds a B.A. in Biology from UC San Diego and an M.S. in Human Physiology from UC Davis, and currently serves in multiple external leadership positions in biopharma companies .

Past Roles

OrganizationRoleTenureCommittees/Impact
Nuvelution Pharma Inc.Chief Executive OfficerNov 2015 – Dec 2020Co-founder; operating leadership
Nuvelution Pharma Inc.Co-Founder and Senior AdvisorJun 2015 – Dec 2020Strategic advisory
Palladio BiosciencesChairman of the BoardApr 2019 – Feb 2021Board leadership
IMIDomics SLActing President and Chief Business OfficerDec 2019 – PresentExecutive leadership
Janpix Inc.Executive ChairmanDec 12, 2019 – PresentCompany oversight
Bay City CapitalManaging Director and CFONot disclosedInvestment/finance leadership
Epoch Biosciences (acquired by Nanogen)President and CFONot disclosedOperating leadership
Ascendancy Healthcare, Inc.Co-founder and CEONot disclosedCompany formation and leadership
Pathways DiagnosticsCEONot disclosedOperating leadership
Reedland Capital PartnersPartnerNot disclosedInvestment role

External Roles

OrganizationRoleTenureExchange/Listing
Compugen Ltd.Non-Executive Board Member (Director)Jun 2018 – PresentNasdaq
Carisma Therapeutics Inc.Chair of the BoardNov 2021 – PresentNasdaq
Kaerus Biosciences Ltd.Executive ChairNot disclosedPrivate
IMIDomics SLActing President and CBODec 2019 – PresentPrivate

Board Governance

  • Independence: Zweifach is an independent director under Canadian securities laws and Nasdaq rules .
  • Committee work: He served on the Audit Committee in 2023–2024 alongside Franklin Berger (Chair), Gary Sollis, and Marella Thorell, providing oversight of financial reporting and auditor independence .
  • Current committee leadership (board-wide): Audit Committee chair is Marella Thorell; Compensation Committee chair is Scott Requadt; Corporate Governance & Nomination Committee (CGNC) chair is Gary Sollis (members include Lauren Merendino, Franklin Berger, and Richard Glickman) .
  • Shareholder voting signal: At the March 5, 2025 AGM, Zweifach received 9,112,900 “For” votes (98.63%) with 126,371 “Withheld” (1.37%), indicating strong investor support .
  • Governance policies: ESSA maintains a majority voting policy requiring directors failing to secure a majority of votes cast to tender their resignation, and an advance notice policy for director nominations .
  • Risk oversight: The Board and committees (notably Audit) oversee risk, with independent directors holding regular in-camera sessions; the Board meets at least quarterly .
  • Attendance: Individual director meeting attendance rates are not disclosed in the cited materials .

Fixed Compensation

  • Board cash fee structure (annual retainers)
ComponentFY 2024 Schedule (per 2024 proxy)FY 2025 Schedule (per 2025 proxy)
Board Member$35,000 $40,000
Board Chair$60,000 $70,000
Audit Committee – Member$7,000 $7,000
Audit Committee – Chair$15,000 $18,500
Compensation Committee – Member$6,000 $6,000
Compensation Committee – Chair$12,000 $12,000
Corporate Governance & Nomination – Member$4,000 $4,000
Corporate Governance & Nomination – Chair$8,000 $8,000
  • Director cash actually paid (FY 2024)
DirectorFees Earned or Paid in Cash ($)Option Awards ($, grant-date FV)Total ($)
Sanford Zweifach$50,500 $451,888 $502,388
  • Cost structure signal: The company disclosed base increases for Board remuneration effective April 2024 and a higher number of directors compared to the prior period, contributing to increased director fees .

Performance Compensation

  • Equity framework for non-employee directors:
ItemDetail
Initial option grant (upon appointment)50,000 options vest ratably over 36 monthly installments; no initial grants in 2024
Annual option grantTypically granted on/around AGM; 2024 annual grant was 25,000 options, with 50,000 awarded to members to accommodate prior-year unawarded grants; annual awards vest in full at the first AGM following grant
Option holdings (as of 9/30/2024)Zweifach held 139,000 options to purchase common shares
Performance linkageDirector equity awards are time-based options; no disclosed performance metrics tied to director compensation; hedging/speculation in company securities is prohibited

Other Directorships & Interlocks

PersonCompanyRolePotential Interlock/Notes
Sanford ZweifachCompugen Ltd.DirectorExternal public board; biotech sector
Sanford ZweifachCarisma Therapeutics Inc.ChairExternal public board; biotech sector
Marella Thorell (EPIX director)Carisma Therapeutics Inc.Director & Audit Committee ChairShared external board with Zweifach; potential information flow interlock (not a related-party transaction by itself)

Expertise & Qualifications

  • Qualifications: Operating executive and investor across biotech companies, including CEO, CFO, Chairman/Executive Chair roles; recognized by the Board for compensation committee-relevant expertise serving on compensation committees of other public companies .
  • Education: B.A. Biology (UC San Diego); M.S. Human Physiology (UC Davis) .

Equity Ownership

HolderBeneficially Owned Common Shares% of Shares OutstandingOptions Held (as of 9/30/2024)
Sanford Zweifach89,000 * (less than 1%) 139,000

Note: As of record date January 8, 2025, 44,388,550 shares were outstanding; option shares exercisable within 60 days are included for the holder’s percentage calculation but not for others, per SEC rules .

Governance Assessment

  • Strengths

    • Independence and committee service: Zweifach is independent and has served on the Audit Committee, supporting financial reporting oversight and auditor independence .
    • Shareholder support: 98.63% “For” votes at the March 2025 AGM suggest strong investor confidence in his continued board service .
    • Ownership alignment: Meaningful equity via options (139,000 held as of 9/30/2024) and personal share ownership (89,000 common shares) aligns incentives with shareholders .
    • Governance policies: Majority voting and advance notice policies improve accountability and nomination transparency; anti-hedging policy reduces misalignment risks .
  • Watch items

    • Multi-board load: Concurrent leadership roles at Carisma and other entities may pose time-allocation risks; monitor engagement and attendance disclosures as available .
    • Interlocks: Shared Carisma board service with EPIX director Marella Thorell merits routine monitoring for conflicts; ESSA’s Related Person Transactions Policy requires disinterested CGNC approval and annual disclosures, and recent filings report no related-party contracts beyond disclosed policy-compliant matters .
    • Pay dynamics: Board fee base increases effective April 2024 increased director fee expense; continue to assess cash vs equity mix and overall cost vs outcomes as ESSA’s corporate direction evolves post-program termination .
  • Red Flags observed: None material disclosed — filings indicate no director penalties/sanctions, no individual bankruptcies, and no related-party transactions requiring disclosure beyond ordinary-course items; hedging is prohibited .

Appendix: Shareholder Vote Signals (2025 AGM)

ProposalForAgainst/WithheldBroker Non-Votes
Set number of directors18,276,662 596,630 2
Election — Sanford Zweifach9,112,900 (98.63%) 126,371 (1.37%) 9,646,523
Auditors appointment/remuneration18,821,777 (For) 51,517 (Withheld) 0
Say-on-Pay (advisory)6,665,705 (For) 2,561,065 (Against) 9,646,524