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Jill DeSimone

Director at iTeos Therapeutics
Board

About Jill DeSimone

Independent Class I director since March 2024; age 69, with decades of biopharma commercialization and oncology leadership experience. Former President of U.S. Oncology at Merck (2014–2022), after senior roles at Teva and Bristol Myers Squibb; holds a B.S. in Pharmacy (Northeastern University) and completed a fellowship with Wharton. Her term expires at the 2027 annual meeting; the Board has determined she is independent under Nasdaq and SEC rules .

Past Roles

OrganizationRoleTenureCommittees/Impact
Merck & Co., Inc.President, U.S. Oncology2014–2022Built Merck’s oncology division
Teva Pharmaceutical Industries Ltd.SVP, Global Women’s Health2012–2014Senior commercial leadership
Bristol Myers SquibbSVP, U.S. Oncology & Commercial2010–2012U.S. oncology commercialization
Bristol Myers SquibbSVP, U.S. Virology/HIV2006–2010U.S. virology/HIV leadership
Bristol Myers SquibbVarious roles of increasing responsibility1980–2012Long-tenured commercial leadership

External Roles

OrganizationRoleTenure/StatusNotes
Oncternal Therapeutics, Inc.DirectorCurrentPublic company board
Praxis Precision Medicines, Inc.DirectorCurrentPublic company board
Affini-T Therapeutics Inc.DirectorCurrentPrivate company board
Kinnate Biopharma, Inc.DirectorJan 2023–Apr 2024Acquired by XOMA in Apr 2024
Florida Cancer Specialists FoundationBoard memberCurrentNon-profit
Swim Across AmericaBoard memberCurrentNon-profit

Board Governance

ItemDetail
Board class and termClass I; term expires 2027
IndependenceIndependent director under Nasdaq/SEC rules
CommitteesAudit Committee (member); Compensation & Leadership Development Committee (member)
Committee chairsAudit: Ann D. Rhoads; Compensation: Tim Van Hauwermeiren (DeSimone not a chair)
Committee activityAudit met 5x in 2024; Compensation met 3x and acted by unanimous written consent 4x
AttendanceEach director attended ≥75% of Board and committee meetings served (2024)
Executive sessionsNon-management directors met in executive session 4x in 2024
Annual meeting attendanceAll directors attended the 2024 annual meeting
Board leadershipSeparate Chairman (David L. Hallal) and CEO roles
Overboarding stanceNo explicit limits; Nominating & Governance Committee reviews time commitments

Fixed Compensation

ComponentJill DeSimone (2024)Notes
Cash fees$28,826 Based on partial year service and committee roles
Option awards (grant-date fair value)$657,444 ASC 718 fair value; not actual realized value
Total director compensation$686,270 2024
Options held (as of 12/31/2024)68,966 options to purchase common stock Outstanding options count (not all exercisable)
Standard Non-Employee Director Retainers (2024)Amount
Board annual retainer$40,000
Chair of Board additional retainer$110,000
Audit Committee – member$7,500
Audit Committee – chair$15,000
Compensation Committee – member$6,000
Compensation Committee – chair$12,000
Nominating & Governance – member$5,000
Nominating & Governance – chair$10,000
Science & Technology – member$7,500
Science & Technology – chair$15,000

Additional framework: director compensation capped at $750,000 per year ($1,000,000 in first appointment year) under the Amended Policy .

Performance Compensation

Equity Grant DetailAmount/Terms
Annual Award (for continuing directors)Stock option to purchase 24,200 shares; grant date June 11, 2024; vests in full on June 11, 2025, subject to continued service
Initial Grant (on appointment)Value determined at Board discretion within plan/policy limits; terms not itemized in proxy (DeSimone appointed Mar 7, 2024)
Change-in-control termsDirector Initial/Annual Grants subject to full accelerated vesting upon sale of the company, subject to continued service through closing
Performance metrics tied to director payNone disclosed; director equity awards are time-based under the policy

Other Directorships & Interlocks

CategoryDetail
Current public company boardsOncternal Therapeutics; Praxis Precision Medicines
Other boardsAffini-T Therapeutics (private); Florida Cancer Specialists Foundation; Swim Across America
Prior public boardsKinnate Biopharma (until Apr 2024 acquisition)
Interlocks/conflictsCompensation Committee Interlocks: none requiring Item 404 disclosure in 2024; no related-party director relationships disclosed

Expertise & Qualifications

  • Oncology commercialization leader (built Merck’s U.S. Oncology franchise), with extensive P&L and market access experience across oncology and virology; deep big-pharma operating background spanning Merck, Teva, and BMS .
  • Educational grounding in pharmacy; executive fellowship exposure via Wharton, supporting governance and strategic oversight capabilities .

Equity Ownership

HolderBeneficial Ownership% of Shares OutstandingComponents
Jill DeSimone42,851 shares (options exercisable within 60 days) <1% Exercisable options within 60 days; does not include unexercisable holdings
Options outstanding (not all exercisable)68,966 options to purchase common stock (as of 12/31/2024) n/aOutstanding director options balance

Policy note: Insider Trading Policy prohibits short sales, derivative transactions, and hedging; highlights risks of margin/pledging arrangements; no pledging activity disclosed for DeSimone .

Governance Assessment

  • Strengths

    • Independent director with significant oncology commercialization leadership; serves on Audit and Compensation committees, supporting board effectiveness in financial oversight and executive pay decisions .
    • Attendance thresholds met (≥75%); Board maintains executive sessions and separates Chair/CEO roles, aligning with governance best practices .
    • Compensation committee uses independent consultant (Radford) and asserts no consultant conflicts; committee charter emphasizes clawback administration and peer group benchmarking for directors/executives .
  • Potential Investor-Alignment Considerations

    • Multiple external public boards (Oncternal, Praxis) plus other roles may raise overboarding risk; Board does not impose explicit limits and evaluates time commitments case-by-case .
    • Director equity awards feature full accelerated vesting upon a sale of the company, which can dilute transaction-aligned incentives; investors should note this change-in-control acceleration provision in director equity policy .
    • No director stock ownership guidelines are referenced in the proxy; ownership alignment relies on option grants and personal holdings (beneficial ownership <1%) .
  • Conflicts and Related-Party Exposure

    • No related-party transactions disclosed involving DeSimone; 2024 Compensation Committee Interlocks reported none requiring Item 404 disclosure .
  • Trading, Hedging, and Pledging Controls

    • Company policy prohibits short sales, derivatives, and hedging; pledging risks highlighted, but policy does not expressly prohibit pledging; no pledging disclosed for DeSimone .

RED FLAGS

  • Overboarding potential given multiple current boards and committee responsibilities, though the Board reviews time commitments rather than enforcing hard limits .
  • Change-in-control accelerated vesting for director equity awards may be viewed as shareholder-unfriendly by some investors in M&A contexts .