LENZ Therapeutics - Q1 2024

Transcript

Operator (participant)

Ladies and gentlemen, thank you for standing by. At this time, I would like to welcome everyone to LENZ Therapeutics' First Quarter 2024 Financial Results and Business Update. All lines have been placed on mute to prevent any background noise. After the speaker's remarks, there will be a question and answer session. If you would like to ask a question during this time, simply press star followed by the number one on your telephone keypad. If you would like to withdraw your question, again, press the star one. Thank you. I would now like to turn the conference over to Dan Chevallard. Please go ahead, sir.

Dan Chevallard (CFO)

Thank you. Good afternoon, everyone, and thank you for joining us today to discuss LENZ's first quarter 2024 financial results and business updates. My name is Dan Chevallard, Chief Financial Officer of LENZ Therapeutics. We are joined today by Evert Schimmelpennink, our President and Chief Executive Officer, who will provide our business update, as well as Dr. Marc Odrich, Chief Medical Officer, and Shawn Olsson, Chief Commercial Officer, both of whom will join us for Q&A. Before we begin, I would like to remind you that this call will contain forward-looking statements regarding LENZ's future expectations, plans, prospects, corporate strategy, cash runway projections, and performance, which constitute forward-looking statements.

Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, including those discussed in our filings with the SEC. In addition, any forward-looking statements represent only our views as of the date of this webcast and should not be relied upon as representing our views as of any subsequent date. We specifically disclaim any obligations to update such statements. With that, I will now turn the call over to Eve.

Evert Schimmelpennink (President and CEO)

Thank you, Dan, and thank you, everyone, for joining us today. Let me start by saying that the first quarter of 2024 and the weeks following have been transformative for LENZ. In March, we completed our merger with Graphite Bio and a concurrent $53.5 million PIPE financing, and as a result, we became a public company trading on Nasdaq under the ticker LENZ. These transactions led us to be well-capitalized with around $213 million of cash and cash equivalents at the end of the quarter on our balance sheet. Importantly, we anticipate this cash balance to be sufficient to fund our operations to post-launch positive operating cash flow.

I want to acknowledge the hard work that went into this and thank the teams at both LENZ and Graphite Bio, as well as advisors on both sides that got us to this strong position. Only a few weeks after our public debut, we announced our positive Clarity phase III data and selected LNZ-100, a single-agent aceclidine product, as our commercial candidate to treat presbyopia. As a reminder, presbyopia is the inevitable loss of near vision that impacts the daily lives of nearly all people over the age of 45. As the crystalline lens in our eyes hardens with age, the eye is less able to accommodate and focus the incoming light for near vision on the retina, resulting in blurry near vision.

Although the progression of presbyopia is gradual, presbyopes often experience an abrupt change in their daily life as the symptoms become more pronounced starting in their mid-forties, when reading glasses or other corrective aids are suddenly necessary to read text or conduct close-up work. To address the daily challenges faced by presbyopes, we are developing a once-daily pharmacological eye drop that has been shown to be capable of improving near vision throughout the full workday without the need for reading glasses. Before I give a brief summary of the positive Clarity top-line data, I want to highlight that throughout the development of LNZ-100, our objective has always been to commercialize a product that we believe will most effectively meet the needs of the widest range of presbyopes and best create loyalty and value based on an all eyes, all-day brand mission.

That means that we're not only aiming for high efficacy with a rapid onset and long duration, but also that the product candidate has to deliver that consistently across the majority of the presbyopic population. This is why we made sure that the close to 11 hundreds participants in our Clarity studies represented the majority of the 128 million presbyopes in the U.S. alone. We included participants aged 45-75, with a mean age of 55. We also made sure to include people that had a wide range of refractive errors. Think of this as including people that need to wear contact lenses or glasses to correct their distance vision, but also people that have never had to wear any distance vision or correction in their life.

We made sure to also include people that had previously undergone LASIK or cataract surgery, and importantly, we included participants with a wide range of presbyopia to make sure that we have a product that can appeal to mild, moderate, and severe presbyopes. By doing so, we feel confident that the results that we generated truly reflect the potential benefits that LNZ-100 can bring to the vast majority of the close to 2 billion presbyopes globally. On that note, let's talk about the key outcomes of the Clarity phase III study in which LNZ-100, a single-agent, aceclidine product candidate, continued to show strong performance and best-in-class potential.

Consistent with previous trials, and for the moment, focusing on the results for the Clarity two trial, and this is, as this is the direct vehicle control trial, LNZ-100 showed a rapid onset, with 71% of participants achieving three lines or more of near vision improvement, without losing one line or more of distance vision at 30 minutes on the very first day of use of the product. At the primary endpoint of three hours, we also observed a three line or more responder rate of 71%. LNZ-100 also maintains high levels of near vision improvement, with 40% of participants achieving three lines or more of near vision improvement at 10 hours, the last time point measured in our efficacy trials. All results were highly statistically significant, with p-values at each time point of less than 0.001.

We also saw a very impressive near universal response to LNZ-100, with 95% of participants achieving at least two lines of near vision improvement. This is an important measure because it is seen as clinically meaningful and significant for most presbyopes. Notably, 69% of the participants still reported this improvement at the end of the day, 10 hours after dosing. In both efficacy trials, Clarity one and two, the participants used their assigned treatment agent every day for 42 days. We saw similarly high response rates for LNZ-100 across both trials at the various days we brought participants in for measurements. In terms of safety, LNZ-100 was seen to be well-tolerated, with no treatment-related serious adverse events observed in the over 30,000 treatment days across all Three Clarity trials.

Of all reported non-serious adverse events, 95% were classified as mild, believed to be transient, and consistent with those observed in previous trials. Commercial potential was further confirmed by participant surveys, with 90% of participants noticing an improvement in near vision, and 75% of them indicating that they would continue to use LNZ-100 after the study. Together with the broad inclusion criteria we mentioned earlier, we believe this positions LNZ-100 well for the estimated over $3 billion potential market opportunity. We recently received the full data sets of the three Clarity trials and are currently analyzing them for additional insights. While that work is still ongoing, I can share that some of the early new data that is coming out is exciting and continues to show nearly universal high efficacy of LNZ-100.

For example, looking at pooled data across both of our efficacy trials, Clarity one and two, we see that not only did 97% of participants achieve at least a three line improvement at some point, but an impressive 84% improved their near vision by at least four or more lines. We believe that these results indicate that the vast majority of people that, if approved, sample the product, would notice a rapid and meaningful improvement in their near vision. This is something that will play a key role in our future commercialization strategy and could serve as a very strong differentiator from the VUITY launch. As mentioned, we are conducting analysis of the full data set for phase III results beyond the already shared top-line results.

We are excited to announce that we are planning a phase III capstone KOL event on June 18, 2024 in N.Y. With this event, we will share additional data, and importantly, we will have distinguished and respected KOLs and lead investigators from our study share their views on our data, expectations for the clinical practice and market, and firsthand experiences with LNZ-100. We look forward to providing additional information on this event in the weeks ahead. Turning to our upcoming NDA submission, I am pleased to share that the Clarity phase III study was designed in close alignment with the FDA, and the positive top-line data generated concludes the clinical development program for LNZ-100. The team is now fully focused on the execution of the filing, and we are well on track to submit our NDA for LNZ-100 to the FDA in mid-2024.

In parallel to working towards our NDA submission, our commercial launch preparedness is also well underway. In February 2024, LENZ launched its unbranded Eye Am campaign to educate and excite eye care professionals about future presbyopia solution. Over 40 key opinion leaders are involved in the campaign and are featured at eyeamselective.com. That is eyeamselective.com, where eye care professionals can learn about ideal pupil size, iris muscle selectivity, and expected early adopters of presbyopia eye drops. Continuing on that momentum and to support the projected launch following potential FDA approval, LENZ is actively building out its U.S. commercial capabilities, highlighted by completion of third-party logistics contracting in the first quarter of 2024, and the addition of key commercial expertise in direct-to-consumer and influencer marketing....

all in preparation for a potential launch of LNZ-100 as early as the second half of 2025. In summary, we are very pleased with the progress the team has made on all fronts. The recent period has been, and promises to continue to be, a very exciting time at LENZ. With that, I'll hand it over to Dan, our CFO, for an update on our financial results.

Dan Chevallard (CFO)

Thank you, Eve. As Eve mentioned, we're pleased with the successful close of the merger transaction and concurrent PIPE, having ended Q1 with approximately $213.3 million in cash, cash equivalents, and marketable securities, inclusive of the over $117 million acquired in the recent merger and the $53.5 million in proceeds from the concurrent private placement. Importantly, we announced today that this is anticipated to fund the company's cash runway through to post-launch positive cash flow from operations. We believe this puts us in a strong position to focus on execution. Our operating results and resulting cash burn for the first quarter were substantially in line with our plan. As is common around transactions such as what we just completed, there have been and will be into the second quarter, certain non-recurring or one-time transaction costs.

Those aside, our total operating expenses, inclusive of both research and development and sales, general, and administrative expenses for Q1 2024, were approximately $16.1 million, compared to $12.6 million for the same period in 2023. Overall, this increase was substantially a result of additional operating costs incurred in our preparations for being a publicly traded company and early commercial planning. More specifically, our research and development expenses for Q1 2024 were $10.5 million, which was materially consistent with research and development expenses of $10.3 million for the same period in 2023. Substantially all research and development expenses incurred for these comparative periods related to the clinical development and manufacturing required to support our Phase II Insight and Phase III Clarity clinical trials.

Selling general and administrative expenses for Q1 2024 increased to $5.6 million, compared to $2.3 million for the same period in 2023. This increase was primarily driven by costs associated with preparations to be a publicly traded company, in addition to an increase in pre-launch commercial expenses. As well, expenses in Q1 2024 included a non-recurring, non-cash, stock-based compensation charge associated with the merger. Finally, our net loss per share, both basic and diluted, was $3.53 per share in the first quarter of 2024 on a net loss of $16.6 million, compared to a net loss per share of $6.50 per share in the first quarter of 2023 on a net loss of $12.7 million.

Please note that these loss per share figures considered only the weighted average common stock outstanding for the respective periods, and thus, most notably for Q1 2024, do not fully weight any of, one, the convertible preferred and convertible common stock from pre-merger private LENZ that converted into common stock upon the merger close, totaling 11.3 million shares. Two, the shares acquired from legacy Graphite shareholders as of the merger date, totaling 8.3 million shares, or three, shares of common stock issued in the 2024 concurrent private placement, totaling 3.6 million shares. More simply stated, we ended Q1 2024 with approximately 25.5 million shares of common stock outstanding, most of which were not fully weighted in our Q1 2024 net loss per share previously noted.

Now, as we advance from here, our allocation of capital will begin to change over the balance of the year, and we would like to take a moment to highlight the following three key items on this point. First, research and development and clinical development spend will decrease over 2024 due to the wind down of our positive Phase III Clarity studies, while prioritizing the financial support necessary to enable a successful mid-2024 NDA submission. Second, we plan to allocate more emphasis and more capital toward the ramp-up of our commercial infrastructure and pre-launch activities over the balance of the year. And third, eliminating for the non-recurring nature of our transaction-related costs, we will aim to maintain discipline in managing our general and administrative costs associated with being a newly publicly traded company.

We look forward to executing on what is a clear path forward for the company towards NDA submission in mid-2024 and the potential approval and commercial launch of LNZ-100 in the second half of 2025. With that, I'll turn the call back over to Eve.

Evert Schimmelpennink (President and CEO)

Thanks, Dan. Operator, we're now happy to take questions.

Operator (participant)

Thank you. The floor is now open for questions. If you have dialed in and would like to ask a question, please press star one on your telephone keypad to raise your hand and join the queue. If you would like to withdraw your question, simply press star one again. Your first question comes from the line of Joseph Catanzaro with Piper Sandler. Your line is open.

Joseph Catanzaro (Director and Senior Biotech Equity Analyst)

Hey, everybody, appreciate you taking my questions. Maybe, maybe two quick ones from me. First, on the NDA submission, can you maybe just help us better understand some of the gating factors there to getting that filing done? Is, is it mostly paperwork, or are there sort of other things going on in the background, and is there any risk to maybe timelines slipping there as you wait for some of those things to get done? And then second, maybe as we look towards the KOL event, you know, are there any sort of additional analyses that you're performing within the Clarity data sets and sort of maybe some new things we might expect to see, at that June event, and what could be important there? Thanks.

Evert Schimmelpennink (President and CEO)

Thanks, Joe. Great questions. Let me take them. So first one, as we work towards the NDA submission, in the middle of the year, so like I said, we believe that with the Clarity trials, we've completed now a full clinical program, and we have the final pieces of the clinical data in our hands. Over the years, we've been very well aligned, and we'll continue to be very well aligned with the FDA. So we have high confidence in the fact that we have a complete data set, and therefore, the team is now really fully focused on compiling the NDA. So, you know, to paraphrase what you were saying, it is paperwork from here on out. Doesn't mean that it's not a lot of work, and therefore, the team is really focused on that.

You know, we have the right people in place, so we're very confident that we will meet that submission timeline that we've guided to in the middle of 2024. So your second question as to the KOL event, again, as we've mentioned on the call, we now have the full data sets of all our three studies, and teams on both sides are analyzing them for additional insight. What we're looking for and what we're starting to see is, you know, really interesting and exciting data around efficacy. You know, how does this product work for the different groups that are in the study? Does it work for mild, moderate, severe presbyopes? Any difference in response on age, how do LASIK patients respond?

Those are some of the things that we're excited to share at the upcoming KOL event. Secondly, it's a great opportunity for, you know, people outside of LENZ to actually share their view on the data, how they see this work in the market, and as I've mentioned, we'll also have lead investigators from the Clarity trial that have true first-hand experience with our product and potentially also with other products, that will share their views on, you know, how it performed in their patients.

Joseph Catanzaro (Director and Senior Biotech Equity Analyst)

Okay, great. That's all super helpful. Appreciate you taking my questions. Thanks.

Evert Schimmelpennink (President and CEO)

Thanks, Joe.

Operator (participant)

Next question comes from the line of Yigal Nochomovitz with Citigroup. Your line is open.

Yigal Nochomovitz (Director and Biotech Equity Research)

Hi, LENZ team, thank you so much. If you mentioned some of the pooled data that you're looking at with the full data set, is any of that potentially something that could make its way into the label language, or is that more gonna stay with the, you know, on the marketing claim front?

Evert Schimmelpennink (President and CEO)

No, great question, Yigal. Thanks for, thanks for joining the call. So looking at the label, the label we actually expect to be fairly broad to begin with. So if you look at the VUITY label, it basically states for the treatment of presbyopia. So, you know, it's hard to expand that label. Now, in the label itself, you'll actually have data cutouts, and that's where the marketing team will continue and will be able to point at that. So we feel this is very important data to ultimately commercialize our product, but also for our healthcare professionals to look at and continue to gain confidence in how the product performs. So again, very excited to see some early data cuts of that data, and as we continue to validate that, we'll start sharing that at our KOL event in June.

Yigal Nochomovitz (Director and Biotech Equity Research)

Thanks. Then with regard to the filing of the NDA, I believe you were also on track for completing some of the stability studies for the product. Given that you're not taking LNZ-101 forward, but rather LNZ-100, is that any faster to finish that stability, or were both of those basically on the same time timetable?

Evert Schimmelpennink (President and CEO)

Yeah, no, both, both were and are on the same timetable. As, as hard as I sometimes try to move times faster, that's impossible, obviously. So what we're truly, you know, bound by the stability clock, and that is going into our filing, timing.

Yigal Nochomovitz (Director and Biotech Equity Research)

And then just the last one, on the distance vision, you know, you had some interesting data suggesting a potential benefit on the distance. How much of that is gonna be emphasized in your marketing pitch, or that's not gonna really be the focus?

Evert Schimmelpennink (President and CEO)

I think, again, that that's gonna be a great additional benefit. So while it is likely not gonna be a label claim, it's not what we're striving for, it is data that we will aim to have included in the label, and therefore, the marketing team can highlight that. We do feel it's a very substantial benefit. You know, one of the additional data cuts that we're looking at is, you know, is there a certain population that notices this more than others or feel the benefit more? And one of the things that, again, anecdotally we hear is that especially people that previously had LASIK and know what 20/20 distance vision looks like, over time, they have lost a little bit.

You know, back at 20/25 or 20/30, appear to feel that benefit. So while it's not a label claim, we feel it's definitely a benefit that is, you know, additive to the near vision effect. That's obviously the main driver of the label.

Yigal Nochomovitz (Director and Biotech Equity Research)

Okay, great. Thank you very much.

Evert Schimmelpennink (President and CEO)

Thanks, Yigal.

Operator (participant)

Next question comes from the line of Tim Lugo with William Blair. Your line is open.

Tim Lugo (Head of Biotech Equity Research)

Thank you for the question, and congratulations on all the progress in the quarter. I know it was a very pivotal quarter for the company. My question is, can you talk about the transient nature of the adverse events that were observed in Clarity? I know I've heard some questions around the headache rates. But also, you know, when I do look at- and maybe, can you talk about anything you're hearing from the market? Because when I've seen some other successful eye care products like dry eye, and then also maybe the other, presbyopia products, the adverse event rate seem to compare well for Clarity. So can you just maybe speak to that a bit?

Evert Schimmelpennink (President and CEO)

Absolutely. Now, thanks, Tim, Tim, for that question. So I think first and foremost, then I'll, I'll get to the other, adverse events. You know, the big thing that we're very pleased with to see in our AE data is that across 30,000 patient treatment days, there were 0 serious adverse events. So I think that's that first and foremost speaks to what we believe, the safety of the product and the profile of the product, and is obviously different than some of the other, products that we've seen out there. And that's really truly, because of the difference of the mechanism of action of aceclidine and how it does not stimulate the ciliary muscle.

So if you then look at the non-serious treatment-related AEs, headaches, and some of the other ones that we've noticed, again, importantly, there, 100% or close to 100% are classified as mild. So in general, we see and the feedback that we get from patients is that this is a very highly tolerable product, very comfortable, with very minor AE issues. To your point, if you compare that to some of the other very successful products, our AE profile is the same, or you could argue, better, than those products. You asked whether they were transient. So everything that we're seeing suggests us that they are. So we obviously have done our phase III trials, have a lot of data there, and we're going through the data on our phase III trials now.

So if you look at the, what's called instillation site irritation, that's basically if you put a an eye drop in your eye, some people feel a mild, very brief sting. You know, think of that as a blink or two, and that's gone. So that's definitely transient. The other ones as well, they all go away very, very quickly. Same goes for the headaches. So if you're one of the few people that actually notice a headache, and again, placebo-controlled, that was about 7.6% in our efficacy trials. So if you're one of those few people that feel that, they classify it as very mild and something that goes away very quickly.

So that may range patient to patient from 10 minutes, 20 minutes to 30 minutes, or maybe slightly more, but it is transient, so it goes away quickly. The data that we're trying to gather now is to see is it tachyphylactic. So over time, as you continue to use the product, does this not even occur anymore after, for example, a week. So this is interesting data to look at. The interesting thing is that we only have very few patients, which is good, that had a headache. So it makes it, you know, interesting to look at the data and see if we can find any trends. If we do, we will make sure to bring those again to the KOL event in June.

Tim Lugo (Head of Biotech Equity Research)

Okay, great. Thank you for all the detail. And maybe can you just speak to the issues with retinal detachment for some of the other products? And I know it's not something we're seeing in Clarity, so hopefully can you just talk about potential label implications?

Evert Schimmelpennink (President and CEO)

Absolutely. So let me answer the label, and I'll hand it over to Marc to explain how our product is different and why we feel we see the again very good lack of retinal detachments with aceclidine. But from a label claim perspective, you know, currently, we expect that the FDA will treat this as a class label effect. I think important is that the data that we have, we can obviously share with healthcare providers. We'll definitely have that discussion with the FDA. But again, you know, currently, we believe that we might have the same general label or class label effect as the other miotics. But again, the product is a very different miotic, and Marc, feel free to jump in and add to that.

Marc Odrich (Chief Medical Officer)

Thank you, Eve. Thank you for the question. The unique feature of aceclidine is that it spares the ciliary muscle, for the most part. And that means it doesn't cause constriction during a critical part, on a critical part of the eye, and that constriction can cause a small amount of traction at something called the vitreous base. So while this is very, if you will, inside the eye and inside baseball, if I can use that analogy, this is something that this particular drug does not do.

And therefore, this has a very low likelihood of causing the same kinds of problems that you would see with the drugs that were more popular than this drug, such as pilocarpine and carbachol, which in fact stimulate this ciliary muscle, so that there is traction on this area. So it's a fundamental difference in our mechanism of action. We are a very specific miotic, which is pupil selective and avoids the ciliary muscle as a mechanism of action.

Tim Lugo (Head of Biotech Equity Research)

Fantastic.

Evert Schimmelpennink (President and CEO)

Thanks, Mark.

Tim Lugo (Head of Biotech Equity Research)

Thank you for all that.

Evert Schimmelpennink (President and CEO)

Thanks, Tim.

Operator (participant)

Last question comes from the line of Mark Goodman with Leerink Partners. Your line is open.

Basma Radwan (VP)

Hi, this is Basma on for Mark. We would like to ask a question about the survey results from the Clarity trials, where you mentioned that 75% of the respondents mentioned that they will continue using LNZ-100. Do you know why 25%? What was the factor that drove 25% to discontinue the drug? And along the same lines, do you think that this 25% is kind of an indicator of the discontinuation rates that you expect in the real world, or do you expect from the use of the drug? And do you actually have any data from market research or analysis from this ongoing long-term safety data trial, I'm sorry, that can give you insight on the discontinuation rates? Thank you.

Evert Schimmelpennink (President and CEO)

Thank you. Thank you for your question. Very insightful. So let me kick that off and then hand it over to Sean for some additional detail. So, first, just to make sure that, or to clarify. So the question was asked after the study was completed. So patients had their last day of use of the product. We then asked them, If this were commercially available, would you want to continue to use the product? So this is not a discontinuing, discontinuation rate in the study by any means. In fact, you know, the vast majority of the patients or the participants completed both the efficacy and the long-term safety studies. And again, that plays to the product being very comfortable but also very effective.

So the 25% that you reference of people that say, yeah, I noticed the effect, but I might not use it going forward, if it's in the real world, we feel can have a couple of different reasons. Maybe those are people that actually are happy with their current near vision solution. So if these people are on bifocals, and they feel that that's, you know, the right solution for them, and they don't wanna change that, that's maybe one reason. Another reason is maybe they feel that this is a cost that they cannot afford. You know, those are some of the things that you can think about. But again, these are not reasons of discontinuation of the product per se, but really, if this product were to be commercially available, would you use it.

Shawn Olsson (Chief Commercial Officer)

Yeah, and when I think commercially about this, I find this very encouraging to see there is results, and we also see it in line with generally our market research. You know, in our corporate presentation, we highlight the interest in this drop. And generally, depending on the age, you know, the amount of people that would seriously consider an eye drop like this, you know, rose all the way up to about 68%. So seeing 75% continue this is after the study is exactly in line with what we expect from our market research. And again, very encouraging data. It's great to see such high numbers. And it also confirms that 81% of those people would expect to use this four-seven days a week. That's from the PROs.

That is almost exactly in line with our market research, which came between 79%-80% of these people being four-seven days a week. So what I find really encouraging is we actually see that our actual outcomes from our phase III trial mimic what we're finding in our market research and as well, which highlights the huge opportunity in this market. And I think as we go towards commercialization, if you think of the sampling strategy, that will really play into that refill rate, which I think is a better thing to focus on, is that refill rate.

You know, because we're gonna have a strong sampling plan up front, that's gonna allow people to try this product, you know, make sure this is for them, which we expect the vast majority to do, and then move on into that, you know, fulfillment and repeat buying of the product. So we see that strategy as, you know, very important in actually improving this, you know, refill rates.

Evert Schimmelpennink (President and CEO)

Thanks, Shawn. And maybe just a last point, too, to add to that. If you were to pluck these percentages in against the 128 million population of presbyopes in the U.S., you end up with a market that's about 15-20 times higher than the $3 billion that we already forecast. So the $3 billion that, that we talk about as the market potential, really takes a, you know, very conservative approach on which part of the 128 million population is ultimately, we feel, going to use it, how often are they going to use that? It also, I think, indicates the, you know, the very significant upside over the $3 billion market that you could see.

Basma Radwan (VP)

Thank you. That's very helpful. Thank you.

Evert Schimmelpennink (President and CEO)

Thank you.

Operator (participant)

There are no further questions at this time. Mr. Evert Schimmelpennink, I turn the call back over to you.

Evert Schimmelpennink (President and CEO)

Thank you, Dimi. Thanks, everyone. Thank you for taking the time to join us today, we look forward to keep you updated, and we'll, we'll see you, hopefully, at the June event. Thanks, everyone.

Operator (participant)

This concludes today's conference call. You may now disconnect.