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W. Bradford Smith

Director at Lyra Therapeutics
Board

About W. Bradford Smith

Independent Class III director since November 2019; age 69; Audit Committee Chair and designated “audit committee financial expert.” Current CFO of Incendia Therapeutics (since Dec 2024); prior CFO/finance leadership roles at Homology Medicines, Ocular Therapeutix, and OmniGuide; director at private gene‑editing company eGenesis; B.S. Biology (Tufts) and MBA (UNH). Board has determined he is independent under Nasdaq rules.

Past Roles

OrganizationRoleTenureCommittees/Impact
Homology Medicines, Inc.CFO, Chief Business Officer, TreasurerMar 2022–Nov 2023; consultant Nov 2023–Mar 2024Senior finance and business leadership during strategic transaction with Q32 Bio announced Nov 2023.
Homology Medicines, Inc.CFO & Treasurer; SecretaryApr 2017–Mar 2022; Secretary Jul 2017–Jun 2020Finance leadership for public biotech.
Ocular Therapeutix, Inc.Chief Financial OfficerMar 2014–Apr 2017Led strategic financings including IPO and follow‑on offerings; executed major development/commercialization deal.
OmniGuide, Inc.Chief Financial OfficerJul 2008–Mar 2014Medical device finance leadership.

External Roles

OrganizationRoleTenureNotes
Incendia Therapeutics, Inc.Chief Financial OfficerSince Dec 2024Current operating role.
eGenesis (private)DirectorSince May 2021Private gene‑editing company board.

Board Governance

ItemDetail
Board class/termClass III director; current Class III terms expire at the 2026 Annual Meeting.
IndependenceBoard determined Mr. Smith is independent under Nasdaq rules.
Committee assignmentsAudit Committee (Chair); Nominating & Corporate Governance Committee (Member).
Financial expertBoard determined Mr. Smith qualifies as an “audit committee financial expert.”
Committee meetings (2024)Audit Committee met 5x; Nominating & Corporate Governance met 3x.
AttendanceIn 2024, each director (other than two named former directors) attended at least 75% of aggregate Board and applicable committee meetings.
Audit oversightSigned the Audit Committee Report as Chair recommending inclusion of audited FY2024 financials in the Form 10‑K.
Lead independent directorJames R. Tobin serves as Lead Independent Director; Board currently chaired by CEO Maria Palasis (post‑Aug 1, 2025).

Fixed Compensation (Director)

Component (FY2024)Amount
Fees earned or paid in cash$64,000
Option awards (grant date fair value)$8,169
Total$72,169

Non‑employee director program (structure): $40,000 annual cash retainer; additional fees: Lead Independent Director $30,000; Audit Chair $20,000; Audit member $10,000; Compensation Chair $15,000; Compensation member $7,500; Nominating & Corporate Governance Chair $10,000; Nominating & Corporate Governance member $5,000. Initial option 60,000; annual option 30,000; annual director options vest in a single installment on the earlier of the day before the next annual meeting or first anniversary.

Performance Compensation (Director)

Award2024 Grant (Fair Value)InstrumentVesting Terms
Annual director equity$8,169 Stock optionsAnnual director options vest in a single installment on the earlier of the day before the next annual meeting or first anniversary of grant; options are granted at FMV; 10‑year term.

Other Directorships & Interlocks

CompanyTypeRoleNotes/Interlocks
eGenesisPrivateDirectorOnly current board disclosed in biography; no current public company directorships listed for Mr. Smith.
Related‑party transactionsRelated‑party disclosures involve Perceptive Advisors/North Bridge; Mr. Smith is not named as a related person in those transactions.

Expertise & Qualifications

  • Deep CFO and capital markets experience (Homology Medicines; Ocular Therapeutix IPO/follow‑ons; OmniGuide), supporting audit chair responsibilities.
  • Designated audit committee financial expert with financial literacy under Nasdaq rules.
  • Scientific/operating domain familiarity (B.S. Biology; biotech/medtech leadership), aiding risk oversight in R&D‑intensive context.

Equity Ownership

MetricAmount/Detail
Beneficial ownership (as of Mar 18, 2025)47,789 shares (all via options exercisable within 60 days); <1% of outstanding.
Options exercisable within 60 days47,789
Total options outstanding (12/31/2024)77,789 (exercisable and unexercisable).
Hedging/pledging policyCompany policy prohibits directors/officers from hedging Company stock (e.g., swaps, collars, exchange funds).

Governance Assessment

  • Strengths: Independent director; Audit Chair and audit committee financial expert; active on Nominating & Corporate Governance; signed FY2024 Audit Committee Report; attendance at or above Board standard; compensation structure balanced with modest cash retainer and time‑vested options aligning with shareholders; company policy prohibits director hedging.
  • Potential watch items: Concurrent external CFO role (Incendia Therapeutics) elevates time‑commitment considerations, though no attendance shortfall was flagged in 2024 disclosures; no related‑party transactions identified involving Mr. Smith in the proxy’s related‑party section.
  • Board structure context: CEO now also serves as Chair following Aug 1, 2025 changes; independent oversight mitigated by Lead Independent Director and fully independent Audit Committee chaired by Mr. Smith.