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Robert Petit

Chief Medical Officer and Chief Scientific Officer at OS Therapies
Executive

About Robert Petit

Robert G. Petit, Ph.D., age 66, is Chief Medical Officer and Chief Scientific Officer of OSTX, roles he has held since September 2019. He holds a Ph.D. from The Ohio State University College of Medicine and a B.S. from Indiana State University; he is credited with being instrumental in securing FDA approvals for six NDAs/BLAs and is named on more than 100 patents, with a focus on immunologic oncology therapies . Proxy disclosures emphasize equity-based alignment and do not provide TSR, revenue growth, or EBITDA growth metrics tied to his compensation; OSTX indicates as an emerging growth company it is not required to conduct say‑on‑pay votes and is evolving its compensation plans .

Past Roles

OrganizationRoleYearsStrategic Impact
Orionis Biosciences Inc.SVP, Head of Early Clinical DevelopmentSince Mar 2022Early-stage development leadership for drug discovery platform
Carisma Therapeutics, Inc.Chief Scientific OfficerJun–Dec 2019Led CSO function for CAR-macrophage technology in solid tumors
Advaxis, Inc. (now Ayala Pharmaceuticals, Inc.)Chief Scientific Officer & EVPMar 2013–Jun 2019Drove Listeria-based immuno-oncology programs; later chairs SAB
Bristol-Myers SquibbU.S. Medical Strategy Lead; Director of Medical Strategy, New Oncology Products; Director of Global Clinical Research2005–2010Oncology medical strategy and global clinical research leadership
MGI Pharma Inc.; Aesgen Inc.VP, Clinical DevelopmentNot disclosedClinical development leadership at oncology-focused biopharmas

External Roles

OrganizationRoleYearsStrategic Impact
RGP Biotech, LLCPrincipal (advisor on non-clinical/clinical programs)Since Jun 2019Advisory to emerging biotechs on development programs
Ayala Pharmaceuticals, Inc.Chairman, Scientific Advisory BoardCurrentOversight and guidance on Lm-based immuno-oncology asset platform
Systems Oncology, LLCScientific Advisory Board memberCurrentInput on cancer therapy discovery and development
Saros TherapeuticsScientific Advisory Board memberCurrentGuidance on re-engineering innate immune activation in cancer IO

Fixed Compensation

Metric20232024
Base Salary ($)$300,000 $420,000
Target Bonus (%)Up to 50% of base Up to 50% of base
Actual Bonus Paid ($)$0 $0
Option Awards – Grant Date Fair Value ($)$0 $245,046
Total Compensation ($)$300,000 $665,046

Note: The proxy also states ISO options issued as of 12/31/2024 had not vested and had a fair value of $0 at filing, while the Summary Compensation Table reports ASC 718 grant‑date fair values; this reflects differing valuation bases and timing in disclosures .

Performance Compensation

Incentive TypeMetricWeightingTargetActual/PayoutVesting
Annual Cash BonusPersonal performance & company performance (Board discretion) Not disclosed50% of base $0 for 2024 N/A
ISO Stock OptionsEquity alignment; service-based vestingNot disclosed400,000 options at $1.86 strike Unvested as of 12/31/2024 3-year vesting commencing Dec 5, 2025
In-the-money value (illustrative)Based on proxy-stated FMVN/AFMV $2.19 (Aug 20, 2025) 400,000 × ($2.19 − $1.86) = $132,000 potential intrinsic value contingent on vesting N/A

Option expiration date not disclosed; maximum option term under plan is up to 10 years, subject to award agreement .

Equity Ownership & Alignment

MetricAs of Aug 20, 2025
Beneficial Ownership – Common Shares (#)200,000
Ownership (% of common outstanding)<1%
Options – Exercisable (#)0 (none exercisable disclosed at FY 2024)
Options – Unexercisable (#)400,000
Option Exercise Price ($)$1.86
Vested vs Unvested SharesNo unvested stock awards disclosed
Shares Pledged as CollateralNo pledging disclosure noted in proxy
Hedging PolicyNo formal hedging policy adopted; board intends to adopt insider trading policy in 2025
Stock Ownership GuidelinesNot disclosed

Employment Terms

TermDetail
TitleChief Medical Officer & Chief Scientific Officer
Employment Letter DateJune 23, 2020
Employment BasisFull-time, at-will
Base Salary (per letter)$20,000 per monthly pay period (historical letter terms; salary later adjusted by board)
Bonus EligibilityUp to 50% of base; Board discretion on personal/company performance
Severance (No Cause/Good Reason)12 months base salary continuation + prorated bonus equal to 35% of annualized base salary
Change-of-Control ProvisionsNone in employment letter
Non-CompeteDuring employment and 1 year post-termination
Non-Solicit1 year post-termination
Confidentiality/IPInvention and non-disclosure agreement; company owns IP developed relating to business
Garden Leave / Post-termination ConsultingNot disclosed

Investment Implications

  • Alignment and upside: A 400,000 ISO grant at $1.86 strike with vesting starting Dec 5, 2025 provides retention leverage; at the proxy-stated $2.19 FMV (Aug 20, 2025), awards were modestly in-the-money pre‑vesting, implying sensitivity to share price performance through 2026–2028 vesting tranches .
  • Retention risk mitigants: Severance terms (12 months base + 35% prorated bonus) offer moderate protection without change‑of‑control enhancements; absence of CoC acceleration may limit “golden parachute” incentives while maintaining cost discipline .
  • Trading and hedging risk: No formal insider trading or hedging policy was adopted as of the proxy; hedging is not prohibited under a stated policy, which is a potential alignment red flag until the board finalizes policies (planned for 2025) .
  • Ownership scale: Direct ownership is 200,000 shares (<1%), with substantial unvested options; no pledging disclosure, no director/exec ownership guidelines disclosed, and thus limited enforced “skin‑in‑the‑game” thresholds near term .
  • Program trajectory: Board seeks to expand the 2023 Incentive Compensation Plan to 10,000,000 shares, indicating reliance on equity incentives for talent retention and performance alignment in a capital‑intensive biotech; performance awards are permitted but metric frameworks were not detailed in the proxy .

Related governance context: OSTX, as an emerging growth company, is not required to conduct say‑on‑pay votes; the compensation program emphasizes equity while conserving cash, consistent with early-stage biotech norms .

Sources

  • Executive biography, roles, age, education:
  • Compensation tables and narrative:
  • Employment letter and severance terms:
  • Outstanding equity awards and option strike/size:
  • Beneficial ownership:
  • Hedging/insider trading policy status:
  • Plan amendment and equity plan overview; FMV reference: