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Paul Scherer

Director at Prelude Therapeutics
Board

About Paul Scherer

  • Appointed as an independent director (Class III) of Prelude Therapeutics effective June 12, 2025; serves on the Compensation Committee and the Nominating & Corporate Governance Committee .
  • Professional background: physician-scientist currently employed by Baker Bros. Advisors LP; prior academic credentials include M.D. and Ph.D. in Neuroscience (Johns Hopkins University) and B.A. in Biology with Neuroscience concentration (University of Pennsylvania) .
  • Initial equity grant: non‑incentive stock options to purchase 76,000 shares, vesting in full at the earlier of the next annual stockholder meeting or one-year anniversary of grant, subject to continued service .
  • Company states it is not aware of related-party transactions or relationships with Dr. Scherer requiring Item 404(a) disclosure; an indemnity agreement will be entered in the standard form used for other directors .

Past Roles

OrganizationRoleTenureCommittees/Impact
Baker Bros. Advisors LPMultiple roles (advisor to publicly traded biotech companies)2018–presentCapital markets and biotech governance exposure

External Roles

OrganizationRoleTenureNotes
Not disclosed in PRLD filingsNo other public company directorships disclosed in PRLD’s 2025 proxy or 8‑K

Board Governance

  • Committee assignments: Compensation Committee member; Nominating & Corporate Governance Committee member .
  • Independence: Nasdaq rules require independence for compensation and nominating/governance committee members; PRLD states committee compositions meet independence requirements generally .
  • Attendance baseline: In 2024 the Board met 5x; Audit 4x; Compensation 4x; Nominating & Corporate Governance 1x; no director attended less than 75% of meetings (pre‑Scherer period) .
  • Anti‑hedging and clawback: Directors are prohibited from hedging Company stock; a compensation clawback policy compliant with Rule 10D‑1 applies to covered executives (board oversight) .

Fixed Compensation

ComponentAmountNotes
Board Cash Retainer (member)$35,000Annual
Additional Retainer – Board Chair$30,000Annual
Audit Committee Chair$15,000Annual
Audit Committee Member$7,500Annual
Compensation Committee Chair$10,000Annual
Compensation Committee Member$5,000Annual
Nominating & Corporate Governance Chair$8,000Annual
Nominating & Corporate Governance Member$4,000Annual

Non‑employee directors are reimbursed for reasonable expenses (e.g., travel) .

Performance Compensation

Equity AwardGrant DateQuantityVestingPlan/Type
Stock OptionsJune 202576,000100% vest at earlier of next annual meeting or one-year anniversary; service-based2020 Equity Incentive Plan; non‑incentive options

No director performance metrics (e.g., TSR/EBITDA targets) are disclosed for director equity; awards are time‑based .

Other Directorships & Interlocks

EntityRelationship to PRLDGovernance Interlock/Note
Baker Bros. Advisors LP/Baker FundsSignificant holder: 23.4% of voting common; 55.8% of non‑voting common; also hold 19,532,015 pre‑funded warrants with ownership caps
Julian C. BakerPRLD director; managing member of Advisor GP to Baker Bros.; compensation paid directly to employer
OrbiMed EntitiesSignificant holder: 25.0% voting common; 44.2% non‑voting common; PRLD director David P. Bonita is an OrbiMed member (disclaims beneficial ownership except pecuniary interest)

Company states no related‑party transactions >$120,000 during 2024–present other than director/NEO compensation .

Expertise & Qualifications

  • Medical/scientific training (M.D./Ph.D., Neuroscience), plus buy‑side experience advising biotech issuers—strong fit for compensation and governance oversight in R&D‑driven organizations .
  • Education: B.A. Biology (Neuroscience concentration) – University of Pennsylvania; M.D. and Ph.D. Neuroscience – Johns Hopkins University .

Equity Ownership

As of FilingTitle of SecurityAmount Beneficially OwnedOwnership FormNotes
Form 3 (filed 06/13/2025)Common Stock0“No securities are beneficially owned.”
Company shares outstanding reference (03/31/2025)Common Stock Outstanding56,454,461Denominator for percent ownership context

Initial option grant of 76,000 shares (unvested at appointment) . No pledging/hedging permitted for directors under insider trading policy .

Governance Assessment

  • Committee readiness: Placement on Compensation and Governance committees aligns with Scherer’s scientific and investor advisory background; Nasdaq independence standards apply to these committees .
  • Ownership alignment: Form 3 shows zero ownership at appointment; alignment will be primarily via time‑based options (76,000) that vest within one year, consistent with PRLD’s director equity policy of annual time‑based option awards .
  • Potential conflicts: Employment at Baker Bros. Advisors alongside the presence of Julian C. Baker on the Board and Baker Funds’ large holdings introduce influence/interlock considerations, though PRLD reports no related‑party transactions requiring Item 404(a) disclosure; committee independence is asserted by the Company and governed by Nasdaq rules .
  • Attendance/engagement: 2024 attendance for the Board and committees met thresholds; Scherer’s tenure began mid‑2025—no personal attendance data yet .

Insider Trades

DateFormKey Disclosure
06/13/2025Form 3Initial Statement of Beneficial Ownership: no securities beneficially owned

RED FLAGS and Risk Indicators

  • Interlocks/influence: Two Baker‑affiliated figures (Scherer employed at BBA; Julian Baker on Board) plus large Baker ownership (voting and non‑voting) elevate perceived influence risk; monitor committee decisions, related‑party reviews, and equity financings for potential conflicts .
  • Hedging/pledging: Anti‑hedging policy reduces misalignment risk; no explicit anti‑pledging statement in proxy—monitor for pledging disclosures in future filings .
  • Pay structure: Director equity is time‑based options; absence of performance conditions limits pay-for-performance signaling (typical for directors) .

Employment & Contracts (Director-specific)

  • Indemnification agreement: Company will enter into standard director indemnity agreement already on file as Exhibit 10.1 to S‑1 (File No. 333‑248628) .
  • Term: Class III director until the 2026 Annual Meeting and until successor elected/qualified or earlier resignation/removal .

Director Compensation Mix and Policy Signals

  • Mix: Cash retainers (board and committee) plus annual time‑based option awards for non‑employee directors; 2024 Annual Grant was 23,500 options vesting on the earlier of next annual meeting or one-year anniversary (illustrates standard approach) .
  • Consultant: Compensia engaged to support executive and board compensation reviews (independent consultant; no conflicts flagged) .

Attendance and Engagement Expectations

  • Board expects regular attendance and preparation; Scherer joins post‑proxy; 2024 Board/committee cadence documented (5/4/4/1 meetings) .

Related-Party Transactions

  • Company reports none >$120,000 for 2024–present involving directors/5% holders, beyond standard compensation; RPT policy assigns review to the Audit Committee (or Governance Committee when appropriate) .

Committee Structure Snapshot (Context)

  • Current committee compositions are fully independent; Audit chaired by Mardi Dier; Compensation chaired by David Bonita; Nominating & Corporate Governance chaired by Julian Baker .

Summary Implications for Investors

  • Governance effectiveness likely benefits from Scherer’s scientific rigor and investor perspective; however, BBA employment plus Baker Funds’ significant ownership warrants heightened monitoring of independence, director decision-making on compensation/financings, and any strategic transactions implicating large shareholders .
  • Alignment should increase as options vest; anti‑hedging reduces misalignment risk; absence of RPTs and adherence to committee independence standards are positive signals .