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David P. Southwell

Director at PTC THERAPEUTICSPTC THERAPEUTICS
Board

About David P. Southwell

David P. Southwell (age 64) is an independent director of PTC Therapeutics, serving on the Board since 2005. He holds a B.A. from Rice University and an M.B.A. from the Tuck School of Business at Dartmouth, and is designated an Audit Committee financial expert. His core credentials span public-company CEO/CFO roles in biotech and extensive capital markets experience, with current service on Rocket Pharmaceuticals’ board .

Past Roles

OrganizationRoleTenureCommittees/Impact
TScan Therapeutics, Inc.Chief Executive Officer; DirectorOct 2018–Mar 2023Led a Nasdaq-listed biotech through development and financing cycles
Inotek Pharmaceuticals, Inc.President & CEO2014–2018 (until merger with Rocket)Operated a public biotech; merger completion with Rocket Pharmaceuticals
Human Genome Sciences, Inc.Executive Vice President & CFO; DirectorCFO: Mar 2010–Sep 2012; Director: 2008–2010Oversaw finance and strategic transactions at a formerly public biopharma
Sepracor, Inc.EVP & CFO; SVP & CFO1994–2008; SVP & CFO 1994–1995Long-tenured finance leadership at a research-based pharma
Lehman Brothers Inc.Investment Banking (various roles)1988–1994Capital markets and advisory experience

External Roles

OrganizationRoleTenureCommittees/Impact
Rocket Pharmaceuticals, Inc.DirectorCurrentPublic biotech board service (committee roles not disclosed)
Spero Therapeutics, Inc.Director2018–2019Nasdaq-listed biotech (committee roles not disclosed)
inVentiv Health, Inc.Director2016CRO prior to recapitalization (committee roles not disclosed)
THL Credit, Inc.Director2007–2016Nasdaq-listed BDC (committee roles not disclosed)

Board Governance

  • Committee assignments: Audit Committee (member), Compensation Committee (member); designated an “audit committee financial expert” by PTCT’s Board .
  • Independence: All directors other than the CEO are independent under Nasdaq rules; Southwell is independent .
  • Attendance and engagement: The Board met 13 times in 2024; each director attended at least 75% of Board and relevant committee meetings; 10 of 11 directors attended the 2024 annual meeting .
  • Board leadership: Chair of the Board and CEO roles are split (Chair: Michael Schmertzler; CEO: Matthew Klein), with independent directors meeting regularly in executive sessions under Corporate Governance Guidelines .
  • Compensation Committee interlocks: No interlocks or insider participation; members (including Southwell) were not officers/employees of PTCT .

Fixed Compensation

Component2024 Amount (USD)Notes
Fees earned in cash (total)$79,500Southwell’s total cash retainers in 2024
Policy context: Board annual retainer$50,000Standard non-employee director cash retainer
Policy context: Audit Committee member retainer$12,000Chair $25,000; Southwell was a member (not chair)
Policy context: Compensation Committee member retainer$10,000Chair $20,000; Southwell was a member (not chair)
Policy context: Ad hoc committee retainer$7,500 (member) / $11,250 (chair)Ad hoc transaction/litigation committees active in 2024
  • Compensation consultant: FW Cook engaged for director pay review; PTCT retained FW Cook for independence, with no conflicts found .
  • 2024 fees remained unchanged vs 2023 per committee review .

Performance Compensation

Grant TypeQuantityVesting ScheduleGrant-Date Fair Value (USD)
Stock options (annual)10,000Vests over one year in 12 equal monthly installments starting Feb 15, 2024 $134,915 (Southwell’s 2024 option award value)
Restricted stock units (annual)4,0001/3 on Jun 18, 2024; 2/3 on Feb 15, 2025 $102,760 (Southwell’s 2024 stock award value)
  • No director PSUs or performance-based equity were disclosed; director equity is time-based for alignment and retention .

Other Directorships & Interlocks

  • Current public company boards: Rocket Pharmaceuticals (director) .
  • Prior public company boards: Spero Therapeutics (2018–2019), THL Credit (2007–2016); inVentiv Health (2016) .
  • Interlocks: PTCT disclosed no compensation committee interlocks or insider participation involving Southwell .

Expertise & Qualifications

  • Finance and capital markets: Former CFO of Human Genome Sciences and Sepracor; investment banking at Lehman Brothers .
  • Biotech operating leadership: CEO roles at TScan Therapeutics and Inotek Pharmaceuticals .
  • Governance: Audit Committee financial expert designation; broad public company board experience .

Equity Ownership

MetricAmountDetail
Total beneficial ownership97,833 sharesLess than 1% of outstanding; record date outstanding shares: 79,237,622
Ownership breakdownOptions exercisable within 60 days: 81,666; RSUs vesting within 60 days: 1,667; Common stock: 12,850; Family trust: 1,650SEC beneficial ownership methodology
Unvested RSUs (as of 12/31/2024)2,666Outstanding director RSUs
Options outstanding (as of 12/31/2024)90,000Outstanding director options
Ownership guidelines3x three-year average cash Board retainer for directors; compliance as of Dec 15, 2024 (or within grace)Company-wide compliance status; directors within guideline framework
Hedging/pledgingProhibited for directors; pre-clearance/Rule 10b5-1 required for tradesInsider Trading Policy

Governance Assessment

  • Strengths: Long-tenured independent director; Audit Committee financial expert; service on both Audit and Compensation Committees; high board engagement benchmarks; equity-based director pay supports alignment; no pledging/hedging; ownership guideline compliance .
  • Compensation signals: Balanced cash/equity mix; time-based options/RSUs; stable fee structure post consultant review indicates discipline; no director performance equity risk elevation .
  • Shareholder signals: Strong 2024 say-on-pay support (98.1%) indicative of investor confidence in compensation governance .
  • Conflicts/related-party exposure: None disclosed involving Southwell; related-party procedures overseen by Audit Committee .
  • Monitoring points: Tenure dating back to 2005 warrants continued focus on refreshment and independence; maintain scrutiny for any future interlocks with PTCT counterparties or compensation consultant conflicts (none currently) .