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Liz Bhatt

President and Chief Operating Officer at Septerna
Executive

About Liz Bhatt

Liz Bhatt, M.S., M.B.A., is Septerna’s Chief Operating Officer since June 2022 and, effective August 1, 2025, also serves as President; she is 57 years old . Her background spans corporate development and operations leadership at Gilead Sciences, Achaogen (COO; company entered bankruptcy in April 2019), and Applied Molecular Transport; she holds a B.A. in Chemistry (Pomona), an M.S. in Biomedical Sciences (UC San Diego), and an MBA (Kellogg, Northwestern) . For 2024, her target bonus was 35% of base salary; corporate objectives (program, platform, finance/BD) paid at 133% of target, resulting in a $209,270 cash bonus . Septerna is an emerging growth company and does not conduct say‑on‑pay votes at this time .

Past Roles

OrganizationRoleYearsStrategic impact
Gilead SciencesVice President, Corporate Development2006–2017 Led BD/corporate development across therapeutic areas
AchaogenChief Business Officer; later Chief Operating Officer2017–2019 Senior operating role; company declared bankruptcy in April 2019
Applied Molecular TransportChief Business & Strategy Officer2019–2022 Led business and strategy; company later merged with Cyclo Therapeutics
Maxygen; Eli LillyCorporate development positionsEarly career BD roles across biotech/pharma

External Roles

OrganizationRoleYearsNotes
eFFECTOR Therapeutics (public)DirectorOct 2020–Jun 2024 Public company board service

Fixed Compensation

Metric20232024
Base salary ($)413,253 449,559
Target bonus (%)35% 35%
Actual bonus paid ($)203,270 209,270
Option awards (grant-date fair value, $)264,173 956,832
All other compensation ($)3,000 3,000

Performance Compensation

MetricWeightingTargetActual attainmentPayoutVesting/Timing
Corporate objectives (program, platform, finance/BD)Not disclosed35% of base salary 133% of target $209,270 (FY2024) Annual cash bonus

Equity Incentives (selected awards)

Award typeGrant dateVesting commencementShares/OptionsExercise price ($)Vesting scheduleExpirationNotes
Restricted stock9/13/20226/15/202265,328 unvested at 12/31/2024 25% at 1-year; 75% monthly over 36 months $1,496,011 MV at $22.90 on 12/31/2024
Stock option11/12/20238/1/202329,550 ex.; 59,101 unex. 2.76 48 equal monthly installments over 4 years 11/11/2033 Time-based
Stock option3/20/20243/1/202411,081 ex.; 48,019 unex. 2.76 48 equal monthly installments over 4 years 3/19/2034 Time-based
Performance-based stock option9/23/202410/28/20243,871 ex.; 89,040 unex. (92,911 total) 6.81 Service-based + performance condition tied to IPO or sale 9/22/2034 Grant-date fair value $799,035 ; IPO completed Oct 2024

Equity Ownership & Alignment

Item (as of dates noted)AmountDetail
Beneficial ownership (as of 4/21/2025)246,857 shares 174,209 common (incl. unvested) + 72,648 options exercisable within 60 days
Ownership as % of shares outstanding (as of 4/21/2025)0.555%246,857 ÷ 44,515,703 outstanding
Outstanding unvested restricted stock (12/31/2024)65,328 $1,496,011 MV at $22.90
Options outstanding (12/31/2024)44,502 exercisable; 196,160 unexercisable Sum of award lines in “Outstanding Equity Awards”
Hedging/short sales policyProhibited for officers/directors/employees; policy highlights risk of margin/pledging Insider trading policy bans hedging, short sales, derivatives

The company’s insider trading policy prohibits hedging/short sales/derivatives; it flags the risks of margin accounts or pledged shares, but pledging prohibition is not expressly stated in the disclosed excerpt. No pledging by Ms. Bhatt is disclosed in company filings .

Employment Terms

ProvisionOutside change-in-control (CIC)Within CIC window (3 months before–1 year after CIC)
Severance cash9 months base salary for Tier 2 (COO) 12 months base salary + 1.0x target bonus (lump sum) for Tier 2
Health benefits (COBRA equiv.)Employer contribution for 9 months Employer contribution for 12 months
Equity accelerationNone beyond plan termsFull acceleration of time-based equity; performance awards per award terms
Original offer letter severance (pre-IPO)9 months base + health; CIC: 9 months base + health + acceleration of time-based equity Superseded by Executive Severance Plan adopted Oct 2024
Other covenantsConfidentiality, IP assignment, non‑solicitation Clawback policy adopted per SEC/Nasdaq (financial restatements)

Investment Implications

  • Pay-for-performance alignment: Cash incentive tied to corporate milestones paid at 133% of target for 2024; target bonus is a modest 35% of base, indicating balanced risk sharing between fixed and variable pay . Option-heavy equity mix with long, monthly vesting supports retention and aligns upside with long-term value creation .
  • Near-term supply/vesting: Ongoing monthly vesting from 2023/2024 time-based options and 2022 restricted stock creates predictable windows for potential selling; the performance-based option’s trigger (IPO in Oct 2024) appears satisfied, leaving service-based vesting as the primary condition going forward .
  • Ownership alignment: Beneficial ownership of 246,857 shares (<1% of outstanding) provides alignment but not controlling influence; policy-level prohibition of hedging/derivatives helps mitigate misalignment risk .
  • Retention and change-of-control economics: Tier 2 severance provides 12 months base + 1.0x target bonus and accelerates time-based equity upon CIC, reducing exit friction and indicating moderate protection without shareholder-unfriendly gross-ups; clawback is in place per SEC/Nasdaq .
  • Governance/role evolution: Elevation to President in Aug 2025 consolidates operational leadership and may signal confidence in execution; no related-party transactions or selection arrangements disclosed for her appointment .