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Akshay Vaishnaw

President of R&D at Scholar Rock Holding
Executive
Board

About Akshay Vaishnaw

Akshay Vaishnaw, M.D., Ph.D., is President of Research & Development at Scholar Rock (effective April 27, 2025) and a Class III director whose current term runs through the 2027 annual meeting; he is age 62, trained in molecular immunology (Ph.D., University of London) and medicine (M.D., University of Wales), and is a Fellow of the Royal College of Physicians (U.K.) . Prior roles include President and President, R&D at Alnylam, and Chief Innovation Officer; he is currently a venture partner at Atlas Venture and serves on Hemab’s board, with prior Editas directorship, underscoring deep drug development leadership . TSR, revenue growth, and EBITDA growth metrics specific to his tenure are not disclosed in company filings.

Past Roles

OrganizationRoleYearsStrategic Impact
Alnylam PharmaceuticalsPresident, R&D; later President; Chief Innovation OfficerPresident R&D: Mar 2018–Jan 2022; President: Jan 2022–Sep 2023; Chief Innovation Officer: Sep 2023–Dec 2024Led drug development and innovation across R&D and corporate strategy
Scholar RockDirector (Class III)Since May 2019 (term expires 2027)Board oversight, committee service aligned to R&D strategy

External Roles

OrganizationRoleYearsNotes
Atlas VentureVenture PartnerSince Mar 2024Early-stage biotech advisory and investing
Hemab Inc.DirectorSince Jan 2024Board service at hematology-focused biotech
Editas Medicine, Inc.Director (prior)Not disclosedPrior governance experience in gene editing

Fixed Compensation

Executive employment (commenced April 27, 2025):

ComponentTermsValue / %
Base SalaryAnnual$800,000
Target Annual Incentive% of base salary60%
Signing BonusLump sum$2,000,000

2024 Non‑Employee Director compensation (prior to executive appointment):

Component (2024)Amount ($)
Cash Fees$56,140
Option Awards (ASC 718 grant date fair value)$112,257
Stock Awards (ASC 718 grant date fair value)$112,860
Total$281,257

Performance Compensation

Incentive TypeMetricWeightingTargetActualPayoutVesting
Annual Incentive (cash)Company annual performance goals set by Board/Comp CommitteeNot disclosedTarget = 60% of base salaryNot disclosedNot disclosedPaid by Mar 15 following bonus year if employed on pay date
Performance RSUs (Initial PSU Award)Stock price “Hurdle Price Target” plus service conditionNot disclosedHurdle price targets (Exhibit A)Not disclosedNot disclosedTime-vest prorates if hurdle achieved at termination; acceleration mechanics in severance/CIC sections

Note: Specific annual performance metrics, weightings, and payout outcomes are not disclosed in the filings.

Equity Ownership & Alignment

ItemAmount / Status
Beneficial Ownership (as of Mar 26, 2025)161,384 shares; “*” indicates <1% of 94,860,246 shares outstanding
Options held (as of Dec 31, 2024)138,429 shares underlying options
RSUs held (as of Dec 31, 2024)13,500 RSUs
2025 Initial Stock Option AwardFair value ≈ $3,000,000; strike at grant-date closing price; 25% vests on first anniversary; remaining 75% vests in 12 equal quarterly installments thereafter
2025 Initial RSU Award100,000 RSUs; 25% vests on the 15th day of the month of each of the first four anniversaries of Effective Date
2025 Initial PSU Award200,000 PSUs; vests per Exhibit A upon meeting Hurdle Price Targets and service conditions
Hedging/PledgingCompany policy prohibits short sales, derivatives, hedging, and pledging absent audit committee approval
10b5‑1 Trading PlanAdopted Feb 27, 2025; through May 29, 2026; up to 6,750 shares for RSU tax sell‑to‑cover transactions

Vesting Schedules

AwardSchedule
Initial Stock Option Award (2025)25% on first anniversary of Apr 27, 2025; then 12 equal quarterly installments for remaining 75%
Initial RSU Award (2025)25% on the 15th day of the month of the first, second, third, and fourth anniversaries of Apr 27, 2025
Initial PSU Award (2025)Per Exhibit A: stock price hurdle(s) plus service; severance provisions provide prorated time-vest if hurdle achieved by termination; CIC provides full acceleration

Employment Terms

ProvisionOutside CICDuring CIC
At‑will; TermAt‑will; no fixed term Same
Severance CashBase Salary + Target Annual Incentive, paid over 12 months 1.5×(Base Salary + Target Annual Incentive), lump sum
Bonus TreatmentPrior Year Bonus (if unpaid) and prorated Current Year Bonus based on actual performance Prior Year Bonus (if unpaid) and prorated Current Year Bonus; “greater of target or actual” basis for proration
COBRA Subsidy12 months 24 months
Equity Acceleration+12 months of time‑based vesting; PSU prorated if hurdle achieved; 4‑month post‑termination window for hurdle achievement; option exercise extended up to 12 months Full acceleration of all outstanding equity; option exercise extended; performance awards vest at greater of target or actual (PSU per Exhibit A)
280G CutbackApplies to Aggregate Payments to avoid 4999 excise tax; ordered reductions to maximize after‑tax amount
Good Reason / CauseDefined (material diminution of duties/salary, breach, relocation >30 miles, directive to violate law; Cure Period applies) Same
Non‑Compete/Non‑SolicitRestrictive Covenant Agreement; consideration includes PSU and severance; most restrictive provision governs
ClawbackSubject to company Compensation Recovery Policy under SEC Rule 10D‑1/Nasdaq 5608; recovery even post‑service
Dispute ResolutionAAA arbitration in Boston; limited court relief for injunctive remedies

Board Governance

  • Class and Term: Class III director; term expires at 2027 annual meeting .
  • Committees: Member, Science, Innovation & Technology Committee (chair: Dr. Flier); Member, Nominating & Corporate Governance Committee (chair: David Hallal) .
  • Independence: Board determined all directors except the CEO (Jay Backstrom) were independent as of the proxy; nominating/compensation committee membership requires independence under Nasdaq rules .
  • Attendance: Board met eight times in 2024; all directors attended ≥75% of Board and committee meetings on which they served; all eleven directors attended the 2024 annual meeting .

Dual‑role implications: Vaishnaw’s April 27, 2025 executive appointment (President, R&D) introduces an independence consideration for committee service under Nasdaq rules; the proxy’s independence determinations pre‑date this change, and the company discloses committee independence requirements and charters on its governance site .

Director Compensation

2024 Non‑Employee Director compensation policy (as of April 9, 2024 revisions):

RoleAnnual Retainer ($)
Board – Non‑employee member45,000
Board – Non‑Executive Chair (additional)115,000
Audit Committee – Member10,000; Chair additional: 10,000
Compensation Committee – Member7,500; Chair additional: 7,500
Nominating & Corporate Governance – Member5,000; Chair additional: 5,000
Science, Innovation & Technology – Member7,500; Chair additional: 7,500

Initial director equity grants vest monthly over three years; annual director equity grants are provided subject to continued service (policy reviewed with assistance from a compensation consultant) .

Compensation Committee Analysis

  • Composition: Kristina Burow (Chair), Michael Gilman, David Hallal; all “independent” under Nasdaq rules .
  • Role: Sets CEO/executive goals, evaluates performance, approves executive and director compensation, oversees plans and grants, retains independent compensation advisors, and manages succession planning .

Trading Plans and Insider Selling Pressure

Name/TitleAction DateEnd DateSharesPurpose
Akshay Vaishnaw, Board MemberFeb 27, 2025May 29, 20266,750Rule 10b5‑1 plan for RSU tax sell‑to‑cover transactions

Company policy prohibits hedging and pledging; any derivatives or equivalent transactions require audit committee approval, mitigating alignment risks .

Employment Terms – Related Policies

  • Related Person Transactions: Audit committee must approve transactions >$120,000 with directors/executives/5% holders and immediate family; review considers business purpose, terms vs. third parties, and benefits to the company .

Performance & Track Record

  • Program Milestones: Company reported FDA priority review acceptance for apitegromab BLA with a PDUFA target action date of September 22, 2025; management highlighted leadership additions including Vaishnaw to support commercial readiness .

Investment Implications

  • Alignment: A large equity mix (options with ~$3M grant-date fair value, 100k RSUs, 200k PSUs) plus PSU hurdle design signals equity‑heavy, performance‑linked incentives, with full acceleration only on CIC, supporting retention but increasing dilution sensitivity if vesting milestones are met .
  • Cash Compensation Risk: A $2M signing bonus and $800k base with 60% target bonus increases fixed cash outlays; outside CIC severance equals salary + target bonus and 12 months COBRA, pointing to moderate termination cost structure .
  • Supply Overhang: Rule 10b5‑1 sell‑to‑cover plan for 6,750 shares through May 2026 indicates periodic selling pressure tied to RSU vesting events (administrative), typically low signal value but relevant to short‑term liquidity .
  • Governance: Dual role (executive + director) raises independence considerations for committee service under Nasdaq rules; the company’s policies prohibit hedging/pledging and maintain robust related‑party oversight, mitigating common red flags .
  • CIC Economics: 1.5× cash severance, 24 months COBRA, and full equity acceleration in CIC create potential “golden parachute” optics but include 280G cutbacks to optimize after‑tax outcomes without gross‑ups, limiting shareholder‑unfriendly tax features .