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James Flynn

Director at SYNLOGIC
Board

About James Flynn

James Flynn, CFA (age 45), has served as an independent director of Synlogic (SYBX) since March 2024. He is the Managing Member and Portfolio Manager of Nerium Capital LLC (founded in 2021), holds an S.B. in Management Science with a finance concentration and a minor in Economic Science from MIT, and is a CFA charterholder . He is currently nominated for re‑election to serve through the 2028 annual meeting, confirming continued board service and independence under Nasdaq rules .

Past Roles

OrganizationRoleTenureCommittees/Impact
Nerium Capital LLCManaging Member & Portfolio Manager2021–present Investment leadership; healthcare and pharma domain exposure
Aptigon Capital (Citadel)Investment management rolesPrior to 2021 (dates not disclosed) Buy-side analysis and portfolio work
Amici Capital, LLCInvestment management rolesPrior to 2021 (dates not disclosed) Buy-side research and investing
Putnam Investments LLCInvestment management rolesPrior to 2021 (dates not disclosed) Institutional asset management experience
ARCA BiopharmaDirectorPrior (dates not disclosed) Board experience in biopharma
Axiom Health, Inc.DirectorPrior (dates not disclosed) Board experience in healthcare

External Roles

OrganizationRoleTenureCommittees/Impact
Lite Strategy, Inc. (NASDAQ: LITS)DirectorSince 2023 Company described as pharmaceutical and digital asset treasury; committee roles not disclosed
RiceBran TechnologiesDirectorSince 2024 Specialty ingredients; committee roles not disclosed

Board Governance

  • Board classification and term: Flynn is in the class with term ending at the 2025 annual meeting and is nominated to serve through the 2028 annual meeting .
  • Independence: Board determined Flynn to be independent under Nasdaq rules .
  • Committee assignments:
    • Audit Committee member (Chair: Richard Shea); met 4 times in 2024 .
    • Compensation Committee member (Chair: Edward Mathers); did not meet in 2024 .
  • Attendance: In 2024, the Board held 29 meetings; all directors attended at least 75% of Board and committee meetings on which they served. The annual meeting was held Dec 4, 2024 and was attended by one director .

Fixed Compensation

YearComponentAmountNotes
2024Fees Earned or Paid in Cash$31,222Under Non‑Employee Director Compensation Policy
2024Option Awards (grant-date fair value)$5,499Initial appointment option; 4,000 options outstanding at 12/31/2024

Structural change: As of April 26, 2025, the Amended Non‑Employee Director Compensation Program provides equity‑only director pay (no cash compensation), with automatic annual restricted stock awards (15,000 shares) and time‑based vesting .

Performance Compensation

Award TypeQuantity / TermsVestingChange-of-Control Treatment
Initial option grant (Mar 2024)4,000 options outstanding at 12/31/2024Not disclosed; option grant made upon initial appointment Not disclosed for director options in 2024
Annual restricted stock (Amended Policy, 2025)15,000 shares per non‑employee directorVests Dec 15 of grant year, subject to service 100% vesting and, if applicable, exercisability immediately prior to a Change in Control
  • Performance metrics: No director performance metrics (e.g., TSR, EBITDA, ESG) are tied to director compensation; grants are time‑based under the Amended Policy .
  • Repricing prohibition: The 2025 equity plan prohibits option/SAR repricing without stockholder approval (except for corporate transactions) .

Other Directorships & Interlocks

CompanyTypePotential Interlock/Conflict
Lite Strategy, Inc. (NASDAQ: LITS)Pharma/digital asset treasuryNo SYBX related‑party transactions disclosed; independence affirmed
RiceBran TechnologiesSpecialty ingredientsNo SYBX related‑party transactions disclosed; independence affirmed

Expertise & Qualifications

  • Healthcare/pharma investing expertise and broad life sciences industry knowledge cited by SYBX Board as qualifications for service .
  • MIT S.B. in Management Science (finance concentration; minor in Economic Science) and CFA charterholder credentials .

Equity Ownership

HolderShares OwnedOptions Exercisable ≤60 daysTotal Beneficial% OutstandingNotes
James Flynn15,0001,33316,333<1%As of Oct 31, 2025; based on 11,698,919 shares outstanding
  • Hedging/pledging: Insider trading policy prohibits short sales, margin loans or other pledging, collars/hedging devices, and trading in publicly traded options on SYBX securities; requires pre‑clearance and imposes blackout periods .
  • Stock ownership guidelines: Not disclosed for directors in the proxy .

Governance Assessment

  • Independence and committee roles: Flynn is independent and sits on both Audit and Compensation, providing oversight across financial reporting and pay; Audit met 4x, but Compensation did not meet in 2024, which is a governance process risk if sustained .
  • Engagement: Board met 29 times; directors achieved ≥75% attendance—adequate engagement. Only one director attended the 2024 annual meeting, signaling limited public‑facing engagement at that event, though SYBX encourages attendance .
  • Alignment and pay design: 2025 shift to equity‑only annual grants with time‑based vesting increases ownership alignment; however, single‑year vesting and full change‑of‑control acceleration for directors can be viewed as entrenchment‑risk features if combined with frequent grants .
  • Conflicts/related parties: No related‑party transactions involving Flynn are disclosed; SYBX has a formal related‑party policy administered by the Audit Committee . His external boards (LITS, RiceBran) and investment role at Nerium are disclosed without identified conflicts with SYBX .
  • Risk indicators:
    • Positive: Independent status; Audit participation; prohibition on hedging/pledging .
    • Watch items: Compensation Committee inactivity in 2024; single‑trigger acceleration for director equity under the Amended Policy .

RED FLAGS: Compensation Committee did not meet in 2024 (process rigor risk if it persists) ; director equity accelerates 100% upon change‑of‑control (potential misalignment if not balanced by robust performance orientation) .