United Therapeutics - Earnings Call - Q4 2024

Executive Summary

• Q4 2024 delivered strong growth: total revenues rose 20% year-over-year to $735.9M, net income increased 39% to $301.3M, and diluted EPS was $6.19 versus $4.36 in Q4 2023. Sequentially, revenue declined from Q3’s $748.9M due to higher gross-to-net deductions tied to Tyvaso contracting, despite record gross revenues and record product shipments, positioning a higher base for future growth.
• Tyvaso franchise remained the primary driver: total Tyvaso revenue reached $415.9M (+19% YoY), with DPI at $273.2M (+28% YoY) and nebulized at $142.7M (+4% YoY), supported by PH-ILD prescriber breadth/depth and Part D dynamics.
• Strategic pipeline catalysts: FDA cleared the IND for the UKidney xenotransplantation clinical trial (first transplant expected mid-2025), and TETON IPF program achieved full enrollment in TETON 1 with top-line data timelines (TETON 2 H2’25; TETON 1 H1’26).
• Management reiterated confidence in double-digit growth for the foundational business and reinforced payer contracting strategy to defend parity ahead of potential competition; no formal 2025 sales guidance provided.
• Wall Street consensus estimates from S&P Global were unavailable at the time of this analysis due to API limits; beat/miss assessment could not be performed (see Estimates Context).

What Went Well and What Went Wrong

What Went Well

• Tyvaso execution: Q4 Tyvaso revenue grew 19% YoY to $415.9M, driven by record patient shipments and near-record referrals/starts; management highlighted strengthened ILD prescriber penetration and continued growth in both PH-ILD and PAH indications.
• Broad product strength: Orenitram (+28% YoY to $107.8M), Remodulin (+17% YoY to $134.5M), and Unituxin (+25% YoY to $67.5M) all posted solid Q4 growth, with Unituxin’s U.S. revenue at $62M on price and volume.
• Pipeline momentum: UKidney IND clearance (phaseless study up to 50 patients); TETON 1 fully enrolled (598 patients), TETON 2 top-line expected H2’25, supporting IPF label expansion efforts and potential DPI bridging thereafter.

Quotes:

• “Congratulations…another record revenue year…third year in a row of record-setting revenue…we have now begun our 3-year cascade of clinical and regulatory events, starting with…IND clearance for our UKidney clinical trial.” – Martine Rothblatt.
• “Our fourth quarter total net revenue was down slightly sequentially…due in part to our recent contracting efforts for Tyvaso…creating a new base from which Tyvaso can continue to grow.” – Michael Benkowitz.
• “Completing enrollment in [TETON 1] brings us one step closer to potentially delivering a transformative…treatment option for…IPF.” – Peter Smith.

What Went Wrong

• Sequential revenue softness: Q4 net revenue declined versus Q3 due to higher gross-to-net deductions from Tyvaso contracting, even as underlying gross revenues were record-setting.
• SG&A step-up: Selling, general, and administrative expense increased 27% YoY in Q4 to $168.5M, with a $6.0M litigation accrual (Sandoz), and share-based compensation nearly doubling YoY, pressuring opex.
• Adcirca headwind: Q4 Adcirca revenue fell 31% YoY to $4.7M, continuing to be a small drag within the portfolio.

Transcript

Operator (participant)

Good morning and welcome to the United Therapeutics Corporation Fourth Quarter 2024 corporate update. My name is Cindy, and I will be your conference operator today. All participants on the call portion of this webcast will be in listen-only mode until the question-and-answer portion of this earnings call. If you would like to ask a question during that time, simply press star, then the number one on your telephone keypad. If you would like to withdraw your question, simply press star, then two on your telephone keypad. Please note this call is being recorded. I will now like to turn the webcast over to Dewey Steadman, Head of Investor Relations at United Therapeutics. Please go ahead.

Dewey Steadman (Head of Investor Relations)

Thank you, Cindy, and good morning. It's my pleasure to welcome you to the United Therapeutics Fourth Quarter 2024 corporate update webcast. Our remarks today will include forward-looking statements representing our expectations or beliefs regarding future events. These statements involve risks and uncertainties that may cause actual results to differ materially. Our latest SEC filings, including Forms 10-K and 10-Q, contain additional information on these risks and uncertainties. We assume no obligation to update these forward-looking statements. Also, today's remarks may discuss the progress and results of our clinical trials or other developments with respect to our products. These remarks are intended solely to educate investors and are not intended to serve as the basis for medical decision-making or to suggest that any products are safe and effective for any unapproved or investigational uses. Full prescribing information for the products is available on our website.

Accompanying me on today's call are Dr. Martine Rothblatt, our Chairperson and Chief Executive Officer, Michael Benkowitz, our President and Chief Operating Officer, James Edgemond, our Chief Financial Officer and Treasurer, Dr. Leigh Peterson, our Executive Vice President of Product Development and Xenotransplantation, and Pat Pozzan, our Executive Vice President of Technical Operations. Note that Michael Benkowitz and my colleague, Harry Sylvers, will participate in a fireside chat and one-on-one meetings at the TD Cowen 45th Annual Healthcare Conference in Boston on March 3rd, and along with Gil Golden, our Chief Medical Officer, I will be at the UBS European Healthcare Conference on March 4th in London, and finally, James Edgemond, Harry, and I will be at the Leerink Global Healthcare Conference in Miami on March 11th.

Then our scientific, commercial, and medical affairs teams will present at the 20th Annual John Vane Memorial Symposium in London on March 7th and 8th, and at the International Society for Heart and Lung Transplantation Conference in Boston on April 27th to the 30th. And now I'll turn the webcast over to Martine for an overview of our development pipeline and business activities. Martine?

Martine Rothblatt (Chairperson and CEO)

Thank you, Dewey, and good morning, everyone. We have slides available for reference, and I encourage you to review those at your leisure. I'm not going to speak directly to the slides. Congratulations to the more than 1,300 Unitherians and to you, our shareholders, for supporting yet another record revenue year for United Therapeutics in 2024. In fact, 2024 was our third year in a row of record-setting revenue. This amazing performance was driven by our relentless drive to deliver patients with rare and underserved diseases a broad array of solutions to help them improve their lives. Beyond our stellar commercial performance, we have now begun our three-year cascade of clinical and regulatory events, starting with the recent IND clearance for our UKidney clinical trial.

This trial is the first FDA cleared registration-supporting clinical trial of a xeno organ and could provide an opportunity to put an end to dialysis for the hundreds of thousands of patients with end-stage renal disease who cannot qualify for a human kidney transplant or who have little chance of obtaining one before their health declines. We expect the first transplant in the middle of this year. Last month, we completed enrollment of the inhaled treprostinil TETON 1 study in idiopathic pulmonary fibrosis. We expect top-line data from the TETON 2 study in the second half of this year and TETON 1 top-line data in the first half of 2026. Treprostinil, which has been scientifically demonstrated to be anti-fibrotic, anti-proliferative, and anti-inflammatory, is far more than just a vasodilator.

We believe its multifactorial mechanisms of action could be complementary to existing approved IPF agents and even to many of the potential IPF drugs in late-stage development. IPF is extremely hard to treat, but we are encouraged with the success we saw in a post-hoc analysis of IPF patients with pulmonary hypertension in the INCREASE study. Our goal is to bring this potential innovation to market as quickly as possible to patients in need of something additional to existing therapies on the market. And that's not all. We're tremendously excited for the potential of ralinepag to be the first true once-a-day oral prostacyclin agonist for pulmonary arterial hypertension patients. If successful, ralinepag could fundamentally change the positioning of prostacyclins in the PAH treatment paradigm, potentially leading to the upfront use of prostacyclins in PAH.

As an example of the potential for ralinepag, selexapag, a twice-daily oral prostacyclin agonist, logs more than $1.5 billion in annual U.S. sales, and this is for a twice-daily oral product with a dose ceiling, unlike ralinepag. We expect to conclude enrollment in the ADVANCE OUTCOMES study later this year, allowing for top-line data in 2026. Literature has long suggested that earlier prostacyclin use leads to better results, and a once-a-day oral would complement traditional ERA and PDE-5 orals that PAH patients generally use for first-line therapy. Any one of these potential products, UKidney, inhaled treprostinil for IPF, or ralinepag, could fundamentally change how patients with ESRD, IPF, or PAH, respectively, are treated, and each represents a multi-billion dollar revenue opportunity for us.

While we've posted record revenue performance, progressed several registration studies, and launched the first revolutionary trial of a xeno organ, we remain focused on the needs of you, our shareholders, through a disciplined financial algorithm and capital allocation philosophy. In the past five quarters, we have touched on all three areas of our capital allocation philosophy across both our commercial and development portfolios. We've invested in CapEx to support our new Tyvaso DPI manufacturing facility and acquired additional real estate to support future commercial manufacturing needs. We also commissioned the world's first clinical-scale DPF in Virginia and plan to complete two others. On corporate development, we acquired IVIVA and Miromatrix to enhance our organ alternative development expertise, and we've licensed in new technologies to support our treprostinil business.

And with all this, we still returned $1 billion to you, our shareholders, through an accelerated share repurchase program that was universally well received. We will continue to evaluate all three core areas of our capital allocation philosophy on an ongoing basis: record performance, progress with our innovative and revolutionary development programs, disciplined financial management, and capital allocation. We've never been in a better position at United Therapeutics, and we're excited to forge ahead in 2025. And with that, I'll now turn the call over to our President, Mike Benkowitz, who will give an overview of our commercial performance for the quarter. Mike.

Mike Benkowitz (President and COO)

Thank you, Martine, and good morning, everyone. Today, as Martine mentioned, we are pleased to report another year of record-breaking revenue driven by double-digit percentage revenue growth for all our major revenue contributors: Tyvaso, Remodulin, Orenitram, and Unituxin, leading to almost 24% growth over full year 2023. For the quarter, we saw 20% revenue growth from the fourth quarter of 2023 and saw record total treprostinil referrals and patient shipments, along with near-record total starts. Our fourth quarter total net revenue was down slightly sequentially, while our gross revenues for the fourth quarter were record-setting. The modest decline in net revenue is due in part to our recent contracting efforts for Tyvaso, which I will discuss in a moment. Total Tyvaso revenue for the fourth quarter was $416 million, a 19% increase over the previous year.

This continued strong commercial execution in what is normally a seasonally challenging quarter was driven by record patient shipments and near-record referrals and starts, largely on par with the previous quarter. The sequential decline in Tyvaso revenue from 3Q to 4Q was primarily driven by a larger gross-to-net deduction associated with our recent contracting efforts that we've been highlighting for the last few quarters. Our investment in these contracting efforts was conducted to help position nebulized Tyvaso and Tyvaso DPI at parity with current and potential future competitor products. As we have previously noted, these new contracts became effective over the third and fourth quarters of 2024, and we saw this impact primarily in the fourth quarter. At this point, we believe these additional investments and rebates have largely been pulled through, creating a new base from which Tyvaso can continue to grow.

Moving to Orenitram, we reported 28% revenue growth in the fourth quarter of 2024 to $108 million, largely in line with the third quarter of 2024, and again, what is normally a seasonally weak fourth quarter for specialty pharmacy ordering. In the fourth quarter, we saw record patient shipments for Orenitram. Close to 50% of Orenitram starts are now coming from Remodulin and transitions, indicating to us that our educational efforts around use with intermediate high-risk patients needing additional PAH treatment, along with scientific discussions about the EXPEDITE study, are influencing Orenitram use. Moving to Remodulin, we reported fourth quarter worldwide revenue of $135 million, up 17% from the prior year period. U.S. revenue grew 11%, setting another record for patient shipments. We continue to see strong referral and start trends for Remodulin. In January, our partner DEKA received FDA clearance for the new RemunityPRO pump.

RemunityPRO is the next generation in subcutaneous pump technology optimized and designed for patients with PAH. RemunityPRO builds on our unique Remunity pump platform with features designed with input from PAH practitioners and patients to further simplify daily use. Compared to Remunity, RemunityPRO offers broader accessibility through intuitive technology and incorporates a touchscreen remote with step-by-step guidance, streamlined alerts, simplified patient filling, and automatic pump turbine priming. We expect to launch RemunityPRO later this year. Finally, Unituxin achieved record revenue of $68 million for the fourth quarter, up 25% from the prior year quarter. U.S. revenue for Unituxin was $62 million, driven by both price and volume increases. This growth demonstrates the product's strong market presence and the effectiveness of our commercial strategies. To wrap up, we are extremely proud of our team's accomplishments this quarter as the underlying dynamics of our business remain very strong.

With the recent investment in our commercial contracting efforts, we believe we are well positioned to continue providing our important medicines to patients while delivering value to our shareholders. Martine, I'll turn things back to you to run the Q&A.

Martine Rothblatt (Chairperson and CEO)

Thank you very much, Mike. Operator, please open the lines to any questions.

Operator (participant)

We will now begin the question-and-answer session. To ask a question, you may press star, then one on your telephone keypad. If you are using a speakerphone, please pick up your handset before pressing the keys. If at any time your question has been addressed and you would like to withdraw your question, please press star, then two. At this time, we will pause momentarily to assemble our roster. Our first question comes from Roger Song of Jefferies. Go ahead, please.

Roger Song (Senior Equity Research Analyst)

Great. Congrats for the quarter. Thank you for taking our question. Maybe start with the top-line commercial franchise, given you don't provide the 2025 sales guidance in. So we understand the growth trajectory for the year. And then also you mentioned some seasonality for Q, and then how should we think about this year in the upcoming quarters? And then I have your one or two pipeline questions. Thank you.

Martine Rothblatt (Chairperson and CEO)

Thank you, Roger, for the kudos, and I'll bounce that question to Mike.

Mike Benkowitz (President and COO)

Sure. So I think as we kind of think about 2025 and beyond as it relates to what we call our foundational business, which is our existing commercial portfolio of products, I think what we've been saying for the last few quarters, last couple of years, really, is that we expect to continue to grow double digits out into the mid-decade. Then obviously with an expected ralinepag and IPF approval for Tyvaso, we can, that growth trajectory should inflect in a meaningful way. Really, even with the contracting efforts we employed over the last couple of quarters or that went to effect over the last couple of quarters, we really see no change in that perspective in terms of the base business for the next year or two years. We're just going to continue to execute commercially and, like I said, deliver that double-digit revenue growth performance.

Martine Rothblatt (Chairperson and CEO)

Perfect answer, Michael. Thank you. Operator, next question.

Operator (participant)

The next question comes from Jessica Fye of JPMorgan. Go ahead, please.

Jessica Fye (Managing Director and Equity Research Analyst of Biotechnology)

Great. Good morning. Thanks for taking my question. So with the first transplant for the UKidney clinical trial expected mid-year, can you talk about what you'll be looking for to support proceeding to the next transplant? I think there's a waiting period in between the first and the second. And then just talk about what proof points in that program would ungate larger-scale investment in additional DPF facilities. Thank you.

Martine Rothblatt (Chairperson and CEO)

Thanks, Jessica. Nice to hear your voice this morning, and I'll flip that question over to Dr. Peterson, our EVP xeno. Right?

Leigh Peterson (EVP of Product Development and Xenotransplantation)

Yeah. Yep. Hi. Yeah. So as you mentioned, this is a single phase I study, and it starts with a cohort of six participants. And then we have a 12-week review period where we will be involving. Well, we're actually involving our DSMB, which is our Independent Data Safety Monitoring Committee, as well as our steering committee throughout the study because it's open label. But we'll have a formal review of all of the data, safety data, and as well as patient and graft survival data at that point, and determine the risk-benefit ratio of going forward into the remainder of what we have planned of up to 50 patients.

As far as the endpoint or the demonstration of success, we're going to be looking again at a six-month graft survival rate, patient survival rate, as well as several parameters of kidney function, and then, of course, of safety, which includes transmission of infections, including potential zoonotic infections.

Martine Rothblatt (Chairperson and CEO)

Leigh, that's a great answer. Thank you so much, and Jess, in terms of additional spending on DPF facilities, it's premature to speculate on that, but it will just be something that we'll consider as the trial proceeds. Operator, next question.

Operator (participant)

The next question comes from Ash Verma of UBS. Go ahead, please.

Ash Verma (Executive Director of SMID Biotech and Biopharma)

Hi. Thanks for taking my question. I wanted to understand how you view the HYPERION impact from Winrevair to your business. This study finished earlier than expected. And in the past, I understand that you've talked about that the Winrevair late line and combo therapy used with some of your products was kind of insulating your PAH position. But now that Winrevair moves earlier line and faster than expected, can Tyvaso still grow on the PAH side? Thanks.

Martine Rothblatt (Chairperson and CEO)

Thank you, Ash, for dialing in this morning. Mike, I think that would be the best person to answer that question.

Mike Benkowitz (President and COO)

Sure. So I think in terms of the Hyperion study, I mean, obviously, we'll see how that plays out over the next couple of quarters. As I said in the answer to the first question, we still expect that we're going to continue to grow double digits across our franchise. I do not think, as we said all along, Winrevair is not a—it's not a cure. It's definitely an addition to the PAH treatment armamentarium, which is great for patients. It doesn't replace prostacyclin. I think what we've seen up till now is that it's being used in combination with prostacyclin. I think that will continue to be the case if, for whatever reason, physicians start to use Winrevair ahead of prostacyclin over the long term.

I think that's immaterial because PAH continues to be a progressive disease, and whether patients start on prostacyclin before or after Winrevair, eventually, they're going to get to a prostacyclin. So as we kind of think about our business over the long term, we think the impact's going to really be immaterial.

Martine Rothblatt (Chairperson and CEO)

Excellent, Michael. Operator, next question.

Operator (participant)

The next question comes from Joseph Thome of TD Cowen. Go ahead, please.

Joseph Thome (Managing Director and Senior Biotechnology Equity Research Analyst)

Hi there. Good morning. Thank you for taking my question and congrats on the progress. Maybe another on the xenotransplant. Can you put into context the baseline disease severity of the first patients that will be enrolled, maybe as it relates to kind of the baseline disease severity of the UKidney? And then related to that, we've obviously been able to follow these patients' progress through either press releases from the hospitals themselves or news sources. I guess, do you expect this to continue in the formal clinical study? As early as yesterday, it seems like Ms. Luny was able to return home, and we can kind of watch this as it happens. Is that going to be the case in the formal study as well? Thank you.

Martine Rothblatt (Chairperson and CEO)

Thank you, Joe. I think Dr. Peterson could give you a very good answer on that question.

Leigh Peterson (EVP of Product Development and Xenotransplantation)

Yeah. So I think your second question was about how we will follow our clinical study patients with regard to the news and what's been shown with Ms. Luny. We will not be doing that. For clinical studies, the data are, there's patient privacy. It will not be the same as what you've seen with this EIND case. It'll be more like a traditional clinical study where you don't have names and you don't follow that. As far as the eligibility, our eligibility includes two populations of patients. One are patients who are not eligible for the current kidney transplant waitlist, but they don't have several comorbidities. They're not very, very sick patients. Probably like you're asking specifically about the first two heart patients. Our patients won't have severe cardiovascular comorbidities as well as several other. But again, they won't be eligible for the list due to medical reasons.

And then we also have a second population, which probably Ms. Luny would fall into, which is that they are not expected to get an allotransplant due to things such as HLA sensitization or other factors, type O blood, or a combination of these factors. They're not expected to get an allotransplant for at least five years. And so this is a second population where, again, they're on the list, but they're not expected to have a good chance of receiving an allotransplant. So I hope that gives you a little bit of an indication, again, in comparison to Ms. Luny, where you've really been able to follow her status, which is really great. We're really, really happy to help patients like her. And probably the second category of patients is very similar to what you understand and what we understand where she is.

Martine Rothblatt (Chairperson and CEO)

Thank you, Dr. Peterson. Superb 360-degree answer. Next question, Operator.

Operator (participant)

The next question comes from Roanna Ruiz of Leerink. Go ahead, please.

Roanna Ruiz (Senior Managing Director and Biotechnology Analyst)

Good morning, everyone. So question about Tyvaso in PH-ILD specifically. Could prescribing growth on the ILD side plus increase in commercial volumes under Part D redesign possibly outweigh some seasonality trends from 1Q going to 2Q? Just curious if there's any color on that.

Martine Rothblatt (Chairperson and CEO)

Very interesting question, Roanna. Michael, can you answer that?

Mike Benkowitz (President and COO)

Sure. I think in terms of the first part of the question around PH-ILD growth, as you recall, we expanded our sales force coming into 2024 really to try and drive prescribing growth in the PH-ILD or in the—I'm sorry, in the ILD treaters, those physicians that are seeing the PH-ILD patients. So prior to that, or at least at launch and up until then, I think what we were seeing is the vast majority of PH-ILD patients were being referred to pulmonary hypertension clinics, and it was those physicians that were prescribing Tyvaso. And so, but as you kind of think of the patient population, that really wasn't a sustainable model going forward if we really were going to have an impact and be able to penetrate the market.

So that was really sort of the idea behind the expansion was to really start to continue to educate the ILD treaters on not only the disease, but how to use Tyvaso, how to start and manage these patients. And so I will say that that so far has paid off in spades. If you look at our prescriber growth over the course of 2024, the majority of that growth is in the ILD treating community. So we are starting to get the breadth of prescribers in that group and then actually starting to get some inroads on the depth. I talk often about the three-plus doctors that get to three-plus patients, then they quickly jump up to six, seven, eight, nine, 10 patients.

We're having a lot of success both in terms of the growth, the breadth of the prescribers, and starting to get more depth among those prescribers. And so I think we just expect that to continue as we move on to 2025 and beyond. And I was just looking at calculating if you look at patient growth between PH-ILD and PAH. The nice thing with Tyvaso is we're actually growing on both indications. So in 2024, we grew roughly, I think it was about 37%, 35%-40% in PH-ILD, still mid-teen growth in PAH. So it's nice to see that we're growing in both indications. So I think hopefully that addresses the first part of your question around prescriber growth and then growth in PH-ILD versus PAH.

As it relates to Part D impact, I think, as we said for the last couple of quarters, I think that largely played out last year. As we saw in Q1, we saw more PAP patients or patient assistance patients convert over to commercial paying patients in Q1 of 2024, and then that continued over the course of the year. We kind of celebrated about roughly 90% of our patients are commercial paying patients, and then 10% are in our PAP program. I would expect that that's going to be kind of the new normal or new baseline going forward. It could shift, bounce around a little bit quarter to quarter, just depending on the type of patient we're getting in, but generally, I would expect to kind of settle in around that.

So I'm not expecting to see much of an impact in Q1 or Q2 as a result of the Part D redesign.

Martine Rothblatt (Chairperson and CEO)

Excellent. Michael, your encyclopedic knowledge is a benefit to all of us. Thank you so much. Really appreciate it. Operator, we only have time for one last question, and whoever that may be, maybe it'll be a question for our Chief Financial Officer since this is an earnings call. Next question, Operator?

Operator (participant)

Okay. The next question comes from Andreas Argyrides. Go ahead, please.

Andreas Argyrides (Managing Director)

Thanks. Good morning. Thanks for taking our question. And Martine, apologies. You put me on the spot on the financial question. I don't think I had that one teed up here. But first of all, kudos to the great year and also to the milestone on getting IND clearance. You're leading the way, and it's pretty fascinating and interesting going forward here and following Luny's progress here, hearing that she's resumed daily activities is a kudos to the team. My question was really just quickly around Tyvaso in IPF, getting a sense of the intellectual property moat that you've built around that, how long you can expect exclusivity, and then quickly on contracting and some of the competitive dynamics behind that. I don't know if I squeezed two in there, but apologies for that.

Martine Rothblatt (Chairperson and CEO)

Yeah. Okay. Well, thank you, Andreas. We appreciate your kudos. You're off the hook on the question for James. We don't really like to discuss publicly the issues relating to IP and whatnot, and we're about out of time. So I'm going to ask just Michael if he could talk about the contracting aspects of our anticipated launch in the IPF. Michael?

Mike Benkowitz (President and COO)

Yeah. So Andreas, I'm not sure if the question was related directly to contracting in IPF or just contracting generally or what we've done thus far. But really, I think the philosophy that we and the strategy we employed last year was to start to lock in payers with some additional rebates in anticipation of future competitors. And then the idea behind that is if we start to have those rebate dollars flowing through, then regardless of where a potential competitor comes in with rebates, we have dollars flowing through. And so that puts us, I think, we think, in a stronger position. It keeps us at parity. I think payers will be less reluctant or, I'm sorry, less likely, more reluctant to enter into contracts that would disadvantage us because at that point, they'd basically be turning off the spigot of the rebate dollars.

So that was really the idea behind the payer strategy, which is get the rebates in place, start to get those dollars flowing, keep us at parity with competitors, and then we feel like if we're really, and then have the discussion with the clinicians around what's the better product for their patients. And we feel very strongly that we're better positioned and very well positioned to succeed on that front.

Martine Rothblatt (Chairperson and CEO)

Thank you, Mike. Perfect answer. Operator, you may now wrap up the call.

Operator (participant)

Thank you for participating in today's United Therapeutics Corporation earnings webcast. A rebroadcast of this webcast will be available for replay for one week by visiting the events and presentation section of the United Therapeutics Investor Relations website at ir.unither.com.