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Caligan Partners LP

CIK:0001727492
Hedge Fund
$419M AUM
17 holdings
New York, NY, United States
Founded:2017
7 employees
Latest filing:Jun 30, 2025

Caligan Partners LP is a specialty hedge fund and SEC-registered investment adviser founded in 2017 and headquartered in New York, NY. Led by David Johnson, the firm focuses on long-biased activist equity strategies, primarily in the healthcare sector, and manages investment portfolios for private funds and pooled investment vehicles. The firm typically serves institutional clients and is known for its activist approach. Employee count is estimated at under 10 based on industry data.

Investment Strategy

Caligan Partners employs an activist, long-biased equity strategy with a concentration in the healthcare sector. The firm actively engages in both long and short positions, targeting publicly traded healthcare companies. It pursues value creation through operational, financial, and governance activism, occasionally participating in distressed debt and high absolute return opportunities. Investment decisions are backed by deep fundamental analysis and efforts to influence target companies’ strategic direction when warranted.

Top Buys
V
VRNAVERONA PHARMA PLC
+$44.7M
M
MRUSMERUS N V
+$18.7M
A
AGIOAGIOS PHARMACEUTICALS INC
+$15.1M
E
EXELEXELIXIS INC
+$10.9M
R
RVMDREVOLUTION MEDICINES INC
+$7.0M
Top Sells
S
SAGESAGE THERAPEUTICS INC
-$24.3M
L
LQDALIQUIDIA CORPORATION
-$18.6M
B
BCRXBIOCRYST PHARMACEUTICALS INC
-$17.6M
M
MLYSMINERALYS THERAPEUTICS INC
-$6.8M
A
ANIKANIKA THERAPEUTICS INC
-$6.4M

Top Holdings

V
VRNAVERONA PHARMA PLC
+26.1%$135.9M
L
LQDALIQUIDIA CORPORATION
+19.4%$101.2M
E
EXELEXELIXIS INC
+12.9%$67.2M
A
AGIOAGIOS PHARMACEUTICALS INC
+6.8%$35.6M
M
MRUSMERUS N V
+6.6%$34.6M

Equity Positions (16)

TickerSecurityWeightMarket ValueSharesAvg CostPriceChange (QoQ)
V
VRNA
VERONA PHARMA PLC26.13%$135.9M1,436,878$16.89$94.58+$44.7M
L
LQDA
LIQUIDIA CORPORATION19.45%$101.2M8,118,892$6.98$12.46-$18.6M
E
EXEL
EXELIXIS INC12.93%$67.2M1,525,730$20.72$44.08+$10.9M
A
AGIO
AGIOS PHARMACEUTICALS INC6.85%$35.6M1,071,258$29.24$33.26+$15.1M
M
MRUS
MERUS N V6.64%$34.6M656,999$46.55$52.60+$18.7M

Options Positions (1)

TickerSecurityActionTypeNotional ValueContractsUnderlying PricePremium PaidChange (Contracts)Change (Value)
S
SLS
SELLAS LIFE SCIENCES GROUP INew
Call
$5.0M23,000$2.19$2.19+23,000+$5.0M

Industry Allocation

PHARMACEUTICAL PREPARATIONS
+78.3%
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
+18.8%
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
+2.9%